ENSG00000079819


Homo sapiens

Features
Gene ID: ENSG00000079819
  
Biological name :EPB41L2
  
Synonyms : EPB41L2 / erythrocyte membrane protein band 4.1 like 2 / O43491
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q23.2
Gene start: 130839347
Gene end: 131063322
  
Corresponding Affymetrix probe sets: 201718_s_at (Human Genome U133 Plus 2.0 Array)   201719_s_at (Human Genome U133 Plus 2.0 Array)   242092_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000434576
Ensembl peptide - ENSP00000434308
Ensembl peptide - ENSP00000434596
Ensembl peptide - ENSP00000494672
Ensembl peptide - ENSP00000486691
Ensembl peptide - ENSP00000437295
Ensembl peptide - ENSP00000437207
Ensembl peptide - ENSP00000436871
Ensembl peptide - ENSP00000436641
Ensembl peptide - ENSP00000436349
Ensembl peptide - ENSP00000436348
Ensembl peptide - ENSP00000436145
Ensembl peptide - ENSP00000435556
Ensembl peptide - ENSP00000434998
Ensembl peptide - ENSP00000338481
Ensembl peptide - ENSP00000357110
Ensembl peptide - ENSP00000376222
Ensembl peptide - ENSP00000397580
Ensembl peptide - ENSP00000402041
Ensembl peptide - ENSP00000431647
Ensembl peptide - ENSP00000431988
Ensembl peptide - ENSP00000432013
Ensembl peptide - ENSP00000432329
Ensembl peptide - ENSP00000432803
Ensembl peptide - ENSP00000432949
NCBI entrez gene - 2037     See in Manteia.
OMIM - 603237
RefSeq - XM_017010364
RefSeq - NM_001350305
RefSeq - NM_001350306
RefSeq - NM_001350308
RefSeq - NM_001350309
RefSeq - NM_001350310
RefSeq - NM_001350311
RefSeq - NM_001350312
RefSeq - NM_001350313
RefSeq - NM_001431
RefSeq - XM_006715362
RefSeq - XM_011535524
RefSeq - XM_011535525
RefSeq - XM_011535527
RefSeq - XM_011535528
RefSeq - XM_011535529
RefSeq - XM_011535530
RefSeq - XM_011535534
RefSeq - XM_011535536
RefSeq - XM_017010349
RefSeq - XM_017010350
RefSeq - XM_017010351
RefSeq - XM_017010352
RefSeq - XM_017010353
RefSeq - XM_017010354
RefSeq - XM_017010355
RefSeq - XM_017010356
RefSeq - XM_017010357
RefSeq - XM_017010358
RefSeq - XM_017010359
RefSeq - XM_017010360
RefSeq - XM_017010361
RefSeq - XM_017010362
RefSeq - XM_017010363
RefSeq - NM_001135554
RefSeq - NM_001135555
RefSeq - NM_001199388
RefSeq - NM_001252660
RefSeq - NM_001350302
RefSeq - NM_001350304
RefSeq Peptide - NP_001337233
RefSeq Peptide - NP_001337234
RefSeq Peptide - NP_001337235
RefSeq Peptide - NP_001337237
RefSeq Peptide - NP_001337238
RefSeq Peptide - NP_001337239
RefSeq Peptide - NP_001337240
RefSeq Peptide - NP_001337241
RefSeq Peptide - NP_001337242
RefSeq Peptide - NP_001337243
RefSeq Peptide - NP_001337244
RefSeq Peptide - NP_001422
RefSeq Peptide - NP_001129026
RefSeq Peptide - NP_001129027
RefSeq Peptide - NP_001186317
RefSeq Peptide - NP_001239589
RefSeq Peptide - NP_001337231
swissprot - E9PQN0
swissprot - E9PQD2
swissprot - E9PPC9
swissprot - E9PN54
swissprot - E9PMV8
swissprot - E9PMG5
swissprot - E9PK52
swissprot - E9PJP4
swissprot - E9PII3
swissprot - E9PIG0
swissprot - H0Y5B0
swissprot - E9PRG1
swissprot - O43491
swissprot - Q6R5J7
swissprot - Q6ZSX4
swissprot - E9PHY5
Ensembl - ENSG00000079819
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EPB41L2ENSDARG00000093374Danio rerio
 EPB41L2ENSGALG00000035769Gallus gallus
 O70318ENSMUSG00000019978Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Y2J2 / EPB41L3 / erythrocyte membrane protein band 4.1 like 3ENSG0000008239746
EPB41 / P11171 / erythrocyte membrane protein band 4.1ENSG0000015902345
Q9H4G0 / EPB41L1 / erythrocyte membrane protein band 4.1 like 1ENSG0000008836741
PTPN4 / P29074 / protein tyrosine phosphatase, non-receptor type 4ENSG0000008817922
Q9H329 / EPB41L4B / erythrocyte membrane protein band 4.1 like 4BENSG0000009520321
Q9HCM4 / EPB41L5 / erythrocyte membrane protein band 4.1 like 5ENSG0000011510921
PTPN3 / P26045 / protein tyrosine phosphatase, non-receptor type 3ENSG0000007015918
Q9HCS5 / EPB41L4A / erythrocyte membrane protein band 4.1 like 4AENSG0000012959518
FRMD5 / Q7Z6J6 / FERM domain containing 5ENSG0000017187717
FRMD3 / A2A2Y4 / FERM domain containing 3ENSG0000017215917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR007477  SAB domain
 IPR008379  Band 4.1, C-terminal
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR014847  FERM adjacent (FA)
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR030546  Band 4.1-like protein 2
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0031032 actomyosin structure organization IBA
 biological_processGO:0051301 cell division IEA
 biological_processGO:1904778 positive regulation of protein localization to cell cortex IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0008091 spectrin TAS
 cellular_componentGO:0008180 COP9 signalosome IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0099738 cell cortex region IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0030507 spectrin binding IEA
 molecular_functionGO:0042731 PH domain binding IEA


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000147044 CASK / O14936 / calcium/calmodulin dependent serine protein kinase  / complex / reaction






 

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