ENSMUSG00000026818


Mus musculus

Features
Gene ID: ENSMUSG00000026818
  
Biological name :Cel
  
Synonyms : Bile salt-activated lipase / Cel / Q64285
  
Possible biological names infered from orthology : carboxyl ester lipase
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 28555795
Gene end: 28563403
  
Corresponding Affymetrix probe sets: 10481278 (MoGene1.0st)   1417257_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028161
NCBI entrez gene - 12613     See in Manteia.
MGI - MGI:88374
RefSeq - NM_009885
RefSeq Peptide - NP_034015
swissprot - Q3V2H7
swissprot - Q64285
Ensembl - ENSMUSG00000026818
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cel.1ENSDARG00000017490Danio rerio
 cel.2ENSDARG00000029822Danio rerio
 CELENSGALG00000034436Gallus gallus
 CELENSG00000170835Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nlgn3 / Q8BYM5 / Neuroligin-3 / Q9NZ94*ENSMUSG0000003130233
Nlgn1 / Q99K10 / Neuroligin-1 / Q8N2Q7*ENSMUSG0000006388733
Nlgn2 / Q69ZK9 / Neuroligin-2 / Q8NFZ4*ENSMUSG0000005179031
Ache / P21836 / acetylcholinesterase / P22303* / acetylcholinesterase (Cartwright blood group)*ENSMUSG0000002332829
Ces1e / Q64176 / Carboxylesterase 1E ENSMUSG0000006195929
Bche / Q03311 / Cholinesterase / P06276* / butyrylcholinesterase*ENSMUSG0000002779229
Ces4a / Q8R0W5 / Carboxylesterase 4A / Q5XG92*ENSMUSG0000006056028
Ces1f / Q91WU0 / Carboxylesterase 1F ENSMUSG0000003172528
Ces2b / carboxyesterase 2B / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000005009728
Ces2g / carboxylesterase 2G / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000003187728
Ces1a / carboxylesterase 1A / CES1* / P23141* / carboxylesterase 1*ENSMUSG0000007104728
Ces5a / Q6AW46 / Carboxylesterase 5A / Q6NT32*ENSMUSG0000005801928
Ces1d / Q8VCT4 / Carboxylesterase 1D ENSMUSG0000005697328
Ces2c / Q91WG0 / Acylcarnitine hydrolase / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000006182527
Ces1c / P23953 / Carboxylesterase 1C ENSMUSG0000005740027
Ces1g / Q8VCC2 / Liver carboxylesterase 1 ENSMUSG0000005707427
Ces1h / carboxylesterase 1HENSMUSG0000007415627
Ces2e / Q8BK48 / Pyrethroid hydrolase Ces2e / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000003188627
Ces2f / carboxylesterase 2F / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000006282627
Ces2a / Q8QZR3 / Pyrethroid hydrolase Ces2a / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000005573027


Protein motifs (from Interpro)
Interpro ID Name
 IPR002018  Carboxylesterase, type B
 IPR019819  Carboxylesterase type B, conserved site
 IPR019826  Carboxylesterase type B, active site
 IPR029058  Alpha/Beta hydrolase fold
 IPR033560  Bile salt-activated lipase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006707 cholesterol catabolic process ISO
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0030157 pancreatic juice secretion ISO
 biological_processGO:0046514 ceramide catabolic process IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0004771 sterol esterase activity IEA
 molecular_functionGO:0004806 triglyceride lipase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002647 decreased cholesterol absorption "reduced ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005342 abnormal lipid absorption "anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Esamtm1Dvst/Esamtm1Dvst
Genetic Background: B6.129-Esam1tm1Dvst

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Celtm1Dyh/Celtm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Celtm1Eaf/Celtm1Eaf
Genetic Background: involves: 129S4/SvJae

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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