ENSMUSG00000027792


Mus musculus

Features
Gene ID: ENSMUSG00000027792
  
Biological name :Bche
  
Synonyms : Bche / Cholinesterase / Q03311
  
Possible biological names infered from orthology : butyrylcholinesterase / P06276
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: E3
Gene start: 73635808
Gene end: 73708415
  
Corresponding Affymetrix probe sets: 10498710 (MoGene1.0st)   1421218_at (Mouse Genome 430 2.0 Array)   1436098_at (Mouse Genome 430 2.0 Array)   1437863_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141329
Ensembl peptide - ENSMUSP00000029367
NCBI entrez gene - 12038     See in Manteia.
MGI - MGI:894278
RefSeq - NM_009738
RefSeq - XM_011240000
RefSeq Peptide - NP_033868
swissprot - A0A0A6YVZ5
swissprot - Q03311
Ensembl - ENSMUSG00000027792
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BCHEENSGALG00000034860Gallus gallus
 BCHEENSG00000114200Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ache / P21836 / acetylcholinesterase / P22303* / acetylcholinesterase (Cartwright blood group)*ENSMUSG0000002332850
Nlgn2 / Q69ZK9 / Neuroligin-2 / Q8NFZ4*ENSMUSG0000005179033
Nlgn3 / Q8BYM5 / Neuroligin-3 / Q9NZ94*ENSMUSG0000003130233
Ces2a / Q8QZR3 / Pyrethroid hydrolase Ces2a / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000005573032
Nlgn1 / Q99K10 / Neuroligin-1 / Q8N2Q7*ENSMUSG0000006388732
Ces2c / Q91WG0 / Acylcarnitine hydrolase / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000006182531
Ces5a / Q6AW46 / Carboxylesterase 5A / Q6NT32*ENSMUSG0000005801931
Ces2b / carboxyesterase 2B / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000005009731
Ces2g / carboxylesterase 2G / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000003187731
Ces2e / Q8BK48 / Pyrethroid hydrolase Ces2e / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000003188631
Ces2f / carboxylesterase 2F / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000006282630
Ces2h / carboxylesterase 2H / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000009181329
Ces1d / Q8VCT4 / Carboxylesterase 1D ENSMUSG0000005697329
Ces1e / Q64176 / Carboxylesterase 1E ENSMUSG0000006195929
Ces4a / Q8R0W5 / Carboxylesterase 4A / Q5XG92*ENSMUSG0000006056029
Cel / Q64285 / Bile salt-activated lipase / carboxyl ester lipase*ENSMUSG0000002681829
Ces1g / Q8VCC2 / Liver carboxylesterase 1 ENSMUSG0000005707428
Ces3a / Q63880 / Carboxylesterase 3A / CES3* / Q6UWW8* / carboxylesterase 3*ENSMUSG0000006992228
Ces1f / Q91WU0 / Carboxylesterase 1F ENSMUSG0000003172528
Ces3b / Q8VCU1 / Carboxylesterase 3B / CES3* / Q6UWW8* / carboxylesterase 3*ENSMUSG0000006218128


Protein motifs (from Interpro)
Interpro ID Name
 IPR000997  Cholinesterase
 IPR002018  Carboxylesterase, type B
 IPR014788  Acetylcholinesterase, tetramerisation domain
 IPR019819  Carboxylesterase type B, conserved site
 IPR019826  Carboxylesterase type B, active site
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0014016 neuroblast differentiation IEA
 biological_processGO:0019695 choline metabolic process IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043279 response to alkaloid IEA
 biological_processGO:0050805 negative regulation of synaptic transmission IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051593 response to folic acid IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005641 nuclear envelope lumen IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003990 acetylcholinesterase activity IDA
 molecular_functionGO:0004104 cholinesterase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0033265 choline binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Neurotransmitter clearance
Synthesis of PC
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bchetm1Loc/Bche+
Genetic Background: involves: 129S1/Sv

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bchetm1Loc/Bche+
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000064177 Ghrl / Q9EQX0 / Appetite-regulating hormone Ghrelin Obestatin / Q9UBU3* / ghrelin and obestatin prepropeptide*  / reaction






 

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