ENSMUSG00000064177


Mus musculus

Features
Gene ID: ENSMUSG00000064177
  
Biological name :Ghrl
  
Synonyms : Appetite-regulating hormone Ghrelin Obestatin / Ghrl / Q9EQX0
  
Possible biological names infered from orthology : ghrelin and obestatin prepropeptide / Q9UBU3
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: E3
Gene start: 113716119
Gene end: 113719880
  
Corresponding Affymetrix probe sets: 10546962 (MoGene1.0st)   1448980_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145366
Ensembl peptide - ENSMUSP00000145281
Ensembl peptide - ENSMUSP00000145514
Ensembl peptide - ENSMUSP00000069567
Ensembl peptide - ENSMUSP00000145046
Ensembl peptide - ENSMUSP00000145096
NCBI entrez gene - 58991     See in Manteia.
MGI - MGI:1930008
RefSeq - XM_006506447
RefSeq - NM_001286404
RefSeq - NM_001286405
RefSeq - NM_001286406
RefSeq - NM_021488
RefSeq - XM_006506446
RefSeq Peptide - NP_001273333
RefSeq Peptide - NP_001273334
RefSeq Peptide - NP_001273335
RefSeq Peptide - NP_067463
swissprot - A2RSS9
swissprot - Q7TSD1
swissprot - Q811T4
swissprot - Q9EQX0
swissprot - A0A0N4SVC9
Ensembl - ENSMUSG00000064177
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GHRLENSGALG00000008411Gallus gallus
 GHRLENSG00000157017Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005441  Preproghrelin peptide
 IPR006737  Motilin/ghrelin-associated peptide
 IPR006738  Motilin/ghrelin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity ISS
 biological_processGO:0001696 gastric acid secretion IBA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation ISO
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0008154 actin polymerization or depolymerization ISO
 biological_processGO:0008542 visual learning ISO
 biological_processGO:0009725 response to hormone ISS
 biological_processGO:0009755 hormone-mediated signaling pathway IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016358 dendrite development ISS
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032024 positive regulation of insulin secretion ISS
 biological_processGO:0032095 regulation of response to food ISS
 biological_processGO:0032097 positive regulation of response to food ISS
 biological_processGO:0032100 positive regulation of appetite IMP
 biological_processGO:0032691 negative regulation of interleukin-1 beta production ISS
 biological_processGO:0035483 gastric emptying IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0040010 positive regulation of growth rate IEA
 biological_processGO:0040013 negative regulation of locomotion IMP
 biological_processGO:0042127 regulation of cell proliferation ISO
 biological_processGO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep ISO
 biological_processGO:0042536 negative regulation of tumor necrosis factor biosynthetic process ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043627 response to estrogen ISO
 biological_processGO:0045409 negative regulation of interleukin-6 biosynthetic process ISS
 biological_processGO:0045927 positive regulation of growth IEA
 biological_processGO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep ISO
 biological_processGO:0046676 negative regulation of insulin secretion ISS
 biological_processGO:0046697 decidualization ISS
 biological_processGO:0050728 negative regulation of inflammatory response IBA
 biological_processGO:0051461 positive regulation of corticotropin secretion ISO
 biological_processGO:0051464 positive regulation of cortisol secretion ISO
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0051965 positive regulation of synapse assembly ISS
 biological_processGO:0051969 regulation of transmission of nerve impulse IEA
 biological_processGO:0060079 excitatory postsynaptic potential IMP
 biological_processGO:0060124 positive regulation of growth hormone secretion IBA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IBA
 biological_processGO:0120058 positive regulation of small intestinal transit IEA
 biological_processGO:1903012 positive regulation of bone development IEA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IEA
 biological_processGO:1904000 positive regulation of eating behavior IEA
 biological_processGO:1904179 positive regulation of adipose tissue development IEA
 biological_processGO:1904306 positive regulation of gastro-intestinal system smooth muscle contraction IEA
 biological_processGO:1904346 positive regulation of gastric mucosal blood circulation IEA
 biological_processGO:1904349 positive regulation of small intestine smooth muscle contraction IEA
 biological_processGO:1904468 negative regulation of tumor necrosis factor secretion IEA
 biological_processGO:1905333 regulation of gastric motility IEA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 biological_processGO:2000253 positive regulation of feeding behavior IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0030424 axon ISO
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0016608 growth hormone-releasing hormone activity IEA
 molecular_functionGO:0030296 protein tyrosine kinase activator activity ISS
 molecular_functionGO:0031768 ghrelin receptor binding IBA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: GnaqMhdadsk10/Gnaq+
Genetic Background: C3HeB/FeJ-GnaqDsk10

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005452 abnormal body fat amount "more or less than the normal total amount of connective tissue composed of fat cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prnpc/Prnpc
Genetic Background: MAI/Pas

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prnpc/Prnpc
Genetic Background: MAI/Pas

Allelic Composition: Ghrltm1Lex/Ghrltm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
Show

Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
Show

Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0012289 abnormal non-rapid eye movement sleep pattern "any anomaly in the frequency or duration of the sleep stages characterized by distinct EEG patterns, decreased metabolic activity, slowed breathing and heart rate, and the absence of rapid eye movement and dreaming" [MGI:csmith]
Show

Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023913 Pla2g7 / Q60963 / Platelet-activating factor acetylhydrolase / Q13093* / phospholipase A2 group VII*  / reaction
 ENSMUSG00000021587 Pcsk1 / P63239 / Neuroendocrine convertase 1 / P29120* / proprotein convertase subtilisin/kexin type 1*  / reaction
 ENSMUSG00000027792 Bche / Q03311 / Cholinesterase / P06276* / butyrylcholinesterase*  / reaction
 ENSMUSG00000051136 Ghsr / Q99P50 / Growth hormone secretagogue receptor type 1 / Q92847* / growth hormone secretagogue receptor*  / complex
 ENSMUSG00000071113 Mboat4 / P0C7A3 / Ghrelin O-acyltransferase / Q96T53* / membrane bound O-acyltransferase domain containing 4*  / reaction






 

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