ENSMUSG00000051136


Mus musculus

Features
Gene ID: ENSMUSG00000051136
  
Biological name :Ghsr
  
Synonyms : Ghsr / Growth hormone secretagogue receptor type 1 / Q99P50
  
Possible biological names infered from orthology : growth hormone secretagogue receptor / Q92847
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A3
Gene start: 27371351
Gene end: 27378010
  
Corresponding Affymetrix probe sets: 10491098 (MoGene1.0st)   1446756_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061153
NCBI entrez gene - 208188     See in Manteia.
MGI - MGI:2441906
RefSeq - XM_017319513
RefSeq - NM_177330
RefSeq Peptide - NP_796304
swissprot - Q0VBE5
swissprot - Q99P50
Ensembl - ENSMUSG00000051136
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ghsrbENSDARG00000057117Danio rerio
 GHSRENSGALG00000027947Gallus gallus
 GHSRENSG00000121853Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nmur1 / O55040 / Neuromedin-U receptor 1 / Q9HB89*ENSMUSG0000002623730
Nmur2 / Q8BZ39 / Neuromedin-U receptor 2 / Q9GZQ4*ENSMUSG0000003739329
Ntsr1 / O88319 / neurotensin receptor 1 / P30989*ENSMUSG0000002756829
Trhr / P21761 / thyrotropin releasing hormone receptor / P34981*ENSMUSG0000003876025
Ntsr2 / P70310 / Neurotensin receptor type 2 / O95665* / neurotensin receptor 2*ENSMUSG0000002059124
Trhr2 / thyrotropin releasing hormone receptor 2ENSMUSG0000003907924
Gpr39 / G protein-coupled receptor 39 / O43194*ENSMUSG0000002634321


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR003905  Growth hormone secretagogue receptor type 1
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0008154 actin polymerization or depolymerization IEA
 biological_processGO:0008343 adult feeding behavior IMP
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0009755 hormone-mediated signaling pathway ISS
 biological_processGO:0010700 negative regulation of norepinephrine secretion IEA
 biological_processGO:0030252 growth hormone secretion IGI
 biological_processGO:0032094 response to food IDA
 biological_processGO:0032099 negative regulation of appetite IEA
 biological_processGO:0032100 positive regulation of appetite IMP
 biological_processGO:0032354 response to follicle-stimulating hormone IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032691 negative regulation of interleukin-1 beta production ISS
 biological_processGO:0032869 cellular response to insulin stimulus IDA
 biological_processGO:0036321 ghrelin secretion IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth ISS
 biological_processGO:0042536 negative regulation of tumor necrosis factor biosynthetic process ISO
 biological_processGO:0043134 regulation of hindgut contraction IEA
 biological_processGO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IMP
 biological_processGO:0045409 negative regulation of interleukin-6 biosynthetic process ISS
 biological_processGO:0045923 positive regulation of fatty acid metabolic process IEA
 biological_processGO:0045927 positive regulation of growth IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0046697 decidualization ISS
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0051963 regulation of synapse assembly IMP
 biological_processGO:0051969 regulation of transmission of nerve impulse IEA
 biological_processGO:0060123 regulation of growth hormone secretion IEA
 biological_processGO:0060259 regulation of feeding behavior IEA
 biological_processGO:0060416 response to growth hormone IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071548 response to dexamethasone IEA
 biological_processGO:0090327 negative regulation of locomotion involved in locomotory behavior IEA
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IEA
 biological_processGO:0120058 positive regulation of small intestinal transit IEA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IEA
 biological_processGO:1904000 positive regulation of eating behavior IEA
 biological_processGO:1904008 response to monosodium glutamate IEA
 biological_processGO:1904349 positive regulation of small intestine smooth muscle contraction IEA
 biological_processGO:1904468 negative regulation of tumor necrosis factor secretion IEA
 biological_processGO:1905333 regulation of gastric motility IEA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 biological_processGO:1990314 cellular response to insulin-like growth factor stimulus IEA
 biological_processGO:2000110 negative regulation of macrophage apoptotic process IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0001616 growth hormone secretagogue receptor activity ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity ISO
 molecular_functionGO:0016520 growth hormone-releasing hormone receptor activity ISS
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0042562 hormone binding IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Ghsrtm1Lowl/Ghsrtm1Lowl
Genetic Background: involves: C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Ghsrtm1Lowl/Ghsrtm1Lowl
Genetic Background: involves: C57BL/6J

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gfi1btm1Tmo/Gfi1btm1Tmo
Genetic Background: B6.129-Gfi1btm1Tmo

 MP:0002803 abnormal operant conditional behavior "defects in the operant conditioning system refers to abnormalities in scheduled controlled behavior; behavioral assessment occurs in an automated chamber where responses are reinforced with food" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Etv6tm1(RUNX1)Haho/Etv6+,Runx1tm3Spe/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Ghsrtm1Lowl/Ghsrtm1Lowl
Genetic Background: involves: C57BL/6J

 MP:0003968 abnormal growth hormone level 
Show

Allelic Composition: Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ghsrtm1Lowl/Ghsrtm1Lowl
Genetic Background: involves: C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ghsrtm1Lowl/Ghsrtm1Lowl
Genetic Background: involves: C57BL/6J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Ghsrtm1Lowl/Ghsrtm1Lowl
Genetic Background: involves: C57BL/6J

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gfi1btm1Tmo/Gfi1btm1Tmo
Genetic Background: B6.129-Gfi1btm1Tmo

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ghsrtm1Lowl/Ghsrtm1Lowl
Genetic Background: involves: C57BL/6J

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ghsrtm1Lowl/Ghsrtm1Lowl
Genetic Background: involves: C57BL/6J

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Ghsrtm1Lowl/Ghsrtm1Lowl
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000064177 Ghrl / Q9EQX0 / Appetite-regulating hormone Ghrelin Obestatin / Q9UBU3* / ghrelin and obestatin prepropeptide*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr