ENSMUSG00000020591


Mus musculus

Features
Gene ID: ENSMUSG00000020591
  
Biological name :Ntsr2
  
Synonyms : Neurotensin receptor type 2 / Ntsr2 / P70310
  
Possible biological names infered from orthology : neurotensin receptor 2 / O95665
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 16653382
Gene end: 16660227
  
Corresponding Affymetrix probe sets: 10394685 (MoGene1.0st)   1417151_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106693
Ensembl peptide - ENSMUSP00000152592
Ensembl peptide - ENSMUSP00000152290
Ensembl peptide - ENSMUSP00000152110
NCBI entrez gene - 18217     See in Manteia.
MGI - MGI:108018
RefSeq - XM_006515011
RefSeq - XM_006515013
RefSeq - XM_006515012
RefSeq - NM_008747
RefSeq Peptide - NP_032773
swissprot - P70310
swissprot - A0A1Y7VNS4
swissprot - A0A1Y7VIR1
swissprot - A0A1Y7VN85
Ensembl - ENSMUSG00000020591
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NTSR2ENSG00000169006Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ntsr1 / O88319 / neurotensin receptor 1 / P30989*ENSMUSG0000002756838
Nmur2 / Q8BZ39 / Neuromedin-U receptor 2 / Q9GZQ4*ENSMUSG0000003739325
Nmur1 / O55040 / Neuromedin-U receptor 1 / Q9HB89*ENSMUSG0000002623723
Gpr39 / G protein-coupled receptor 39 / O43194*ENSMUSG0000002634323
Ghsr / Q99P50 / Growth hormone secretagogue receptor type 1 / Q92847* / growth hormone secretagogue receptor*ENSMUSG0000005113621
Trhr2 / thyrotropin releasing hormone receptor 2ENSMUSG0000003907917
Trhr / P21761 / thyrotropin releasing hormone receptor / P34981*ENSMUSG0000003876016


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR003984  Neurotensin receptor
 IPR003986  Neurotensin type 2 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0042391 regulation of membrane potential IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0016492 G-protein coupled neurotensin receptor activity IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Rettm1Heno/Rettm2(RET)Jmi
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Rettm1Heno/Rettm2(RET)Jmi
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Pck1tm1.1Mgn/Pck1tm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rettm1Heno/Rettm2(RET)Jmi
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019890 Nts / Q9D3P9 / Neurotensin/neuromedin N Large neuromedin N Neuromedin N Neurotensin Tail peptide / P30990* / neurotensin*  / complex / reaction






 

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contact: otassy@igbmc.fr