ENSMUSG00000037393


Mus musculus

Features
Gene ID: ENSMUSG00000037393
  
Biological name :Nmur2
  
Synonyms : Neuromedin-U receptor 2 / Nmur2 / Q8BZ39
  
Possible biological names infered from orthology : Q9GZQ4
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 56024987
Gene end: 56041010
  
Corresponding Affymetrix probe sets: 10386086 (MoGene1.0st)   1425943_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044718
NCBI entrez gene - 216749     See in Manteia.
MGI - MGI:2441765
RefSeq - NM_153079
RefSeq Peptide - NP_694719
swissprot - Q8BZ39
Ensembl - ENSMUSG00000037393
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NMUR2ENSGALG00000004101Gallus gallus
 NMUR2ENSG00000132911Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nmur1 / O55040 / Neuromedin-U receptor 1 / Q9HB89*ENSMUSG0000002623742
Ntsr1 / O88319 / neurotensin receptor 1 / P30989*ENSMUSG0000002756828
Gpr39 / G protein-coupled receptor 39 / O43194*ENSMUSG0000002634326
Ntsr2 / P70310 / Neurotensin receptor type 2 / O95665* / neurotensin receptor 2*ENSMUSG0000002059126
Trhr / P21761 / thyrotropin releasing hormone receptor / P34981*ENSMUSG0000003876026
Ghsr / Q99P50 / Growth hormone secretagogue receptor type 1 / Q92847* / growth hormone secretagogue receptor*ENSMUSG0000005113626
Trhr2 / thyrotropin releasing hormone receptor 2ENSMUSG0000003907923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR005390  Neuromedin U receptor
 IPR005392  Neuromedin U receptor, type 2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002023 reduction of food intake in response to dietary excess IMP
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007625 grooming behavior IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling IEA
 biological_processGO:0048016 inositol phosphate-mediated signaling IEA
 biological_processGO:0048265 response to pain IMP
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 molecular_functionGO:0001607 neuromedin U receptor activity ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005229 intracellular calcium activated chloride channel activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008188 neuropeptide receptor activity IEA
 molecular_functionGO:0042924 neuromedin U binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

Allelic Composition: Nmur1tm1Rtor/Nmur1tm1Rtor,Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6NCr * C57BL/6NTac

Allelic Composition: Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nmur2tm1.1Eege/Nmur2tm1.1Eege
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.2Zhe/Apptm1.2Zhe
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.2Zhe/Apptm1.2Zhe
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nmur2tm1.1Eege/Nmur2tm1.1Eege
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011957 decreased compensatory feeding amount "decreased amount of food consumed after a period of fasting" [MGI:csmith]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029236 Nmu / Q9QXK8 / neuromedin U / P48645*  / reaction / complex
 ENSMUSG00000067604 Nms / Q5H8A1 / Neuromedin-S / Q5H8A3*  / reaction / complex






 

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