ENSMUSG00000026237


Mus musculus

Features
Gene ID: ENSMUSG00000026237
  
Biological name :Nmur1
  
Synonyms : Neuromedin-U receptor 1 / Nmur1 / O55040
  
Possible biological names infered from orthology : Q9HB89
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C5
Gene start: 86386303
Gene end: 86426228
  
Corresponding Affymetrix probe sets: 10356335 (MoGene1.0st)   1421667_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027440
Ensembl peptide - ENSMUSP00000148827
Ensembl peptide - ENSMUSP00000148767
Ensembl peptide - ENSMUSP00000148301
NCBI entrez gene - 14767     See in Manteia.
MGI - MGI:1341898
RefSeq - NM_010341
RefSeq - NM_001319227
RefSeq Peptide - NP_001306156
RefSeq Peptide - NP_034471
swissprot - O55040
swissprot - A0A1D5RLB6
swissprot - A0A1C7ZMY0
swissprot - A0A1D5RML5
Ensembl - ENSMUSG00000026237
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nmur1aENSDARG00000060884Danio rerio
 nmur1bENSDARG00000003944Danio rerio
 NMUR1ENSGALG00000007714Gallus gallus
 NMUR1ENSG00000171596Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nmur2 / Q8BZ39 / Neuromedin-U receptor 2 / Q9GZQ4*ENSMUSG0000003739339
Ghsr / Q99P50 / Growth hormone secretagogue receptor type 1 / Q92847* / growth hormone secretagogue receptor*ENSMUSG0000005113626
Ntsr1 / O88319 / neurotensin receptor 1 / P30989*ENSMUSG0000002756824
Ntsr2 / P70310 / Neurotensin receptor type 2 / O95665* / neurotensin receptor 2*ENSMUSG0000002059123
Gpr39 / G protein-coupled receptor 39 / O43194*ENSMUSG0000002634322
Trhr2 / thyrotropin releasing hormone receptor 2ENSMUSG0000003907921
Trhr / P21761 / thyrotropin releasing hormone receptor / P34981*ENSMUSG0000003876020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR005390  Neuromedin U receptor
 IPR005391  Neuromedin U receptor, type 1
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0006939 smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007202 activation of phospholipase C activity IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0048016 inositol phosphate-mediated signaling IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IC
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001607 neuromedin U receptor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008188 neuropeptide receptor activity IPI
 molecular_functionGO:0042924 neuromedin U binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Nmur1tm1Rtor/Nmur1tm1Rtor,Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6NCr * C57BL/6NTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Guca1btm1Amd/Guca1btm1Amd
Genetic Background: involves: 129 * C57BL/6

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr5a2tm1Sakl/Nr5a2tm1Sakl,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029236 Nmu / Q9QXK8 / neuromedin U / P48645*  / complex / reaction






 

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