ENSMUSG00000019890


Mus musculus

Features
Gene ID: ENSMUSG00000019890
  
Biological name :Nts
  
Synonyms : Neurotensin/neuromedin N Large neuromedin N Neuromedin N Neurotensin Tail peptide / Nts / Q9D3P9
  
Possible biological names infered from orthology : neurotensin / P30990
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D1
Gene start: 102481756
Gene end: 102490486
  
Corresponding Affymetrix probe sets: 10372139 (MoGene1.0st)   1422860_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020040
NCBI entrez gene - 67405     See in Manteia.
MGI - MGI:1328351
RefSeq - NM_024435
RefSeq - XM_006513992
RefSeq Peptide - NP_077755
swissprot - Q9D3P9
Ensembl - ENSMUSG00000019890
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ntsENSDARG00000057887Danio rerio
 NTSENSGALG00000027192Gallus gallus
 NTSENSG00000133636Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008055  Neurotensin/neuromedin N


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0050880 regulation of blood vessel size IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043679 axon terminus IBA
 molecular_functionGO:0005184 neuropeptide hormone activity TAS


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Taar1tm1Mmil/Taar1tm1Mmil
Genetic Background: B6.129S2-Taar1tm1Mmil

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0005457 abnormal percent body fat "more or less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy,Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0010149 abnormal synaptic dopamine release "aberrant secretion across synapses of the catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020591 Ntsr2 / P70310 / Neurotensin receptor type 2 / O95665* / neurotensin receptor 2*  / complex / reaction
 ENSMUSG00000027568 Ntsr1 / O88319 / neurotensin receptor 1 / P30989*  / complex / reaction
 ENSMUSG00000021710 Nln / Q91YP2 / Neurolysin, mitochondrial / Q9BYT8* / neurolysin*  / reaction






 

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