ENSMUSG00000021710


Mus musculus

Features
Gene ID: ENSMUSG00000021710
  
Biological name :Nln
  
Synonyms : Neurolysin, mitochondrial / Nln / Q91YP2
  
Possible biological names infered from orthology : neurolysin / Q9BYT8
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 104023057
Gene end: 104109614
  
Corresponding Affymetrix probe sets: 10411882 (MoGene1.0st)   1424981_at (Mouse Genome 430 2.0 Array)   1451555_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153227
Ensembl peptide - ENSMUSP00000153299
Ensembl peptide - ENSMUSP00000104938
NCBI entrez gene - 75805     See in Manteia.
MGI - MGI:1923055
RefSeq - XM_011244699
RefSeq - XM_011244700
RefSeq - XM_011244701
RefSeq - NM_029447
RefSeq Peptide - NP_083723
swissprot - Q91YP2
swissprot - A0A286YD12
swissprot - A0A286YD77
Ensembl - ENSMUSG00000021710
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nlnENSDARG00000019233Danio rerio
 NLNENSGALG00000014769Gallus gallus
 NLNENSG00000123213Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Thop1 / thimet oligopeptidase 1 / P52888*ENSMUSG0000000492961


Protein motifs (from Interpro)
Interpro ID Name
 IPR001567  Peptidase M3A/M3B catalytic domain
 IPR024080  Neurolysin/Thimet oligopeptidase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006111 regulation of gluconeogenesis IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006518 peptide metabolic process IBA
 biological_processGO:1902809 regulation of skeletal muscle fiber differentiation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005758 mitochondrial intermembrane space IBA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019890 Nts / Q9D3P9 / Neurotensin/neuromedin N Large neuromedin N Neuromedin N Neurotensin Tail peptide / P30990* / neurotensin*  / reaction






 

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