ENSMUSG00000056973


Mus musculus

Features
Gene ID: ENSMUSG00000056973
  
Biological name :Ces1d
  
Synonyms : Carboxylesterase 1D / Ces1d / Q8VCT4
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C5
Gene start: 93166068
Gene end: 93197838
  
Corresponding Affymetrix probe sets: 10580635 (MoGene1.0st)   1435370_a_at (Mouse Genome 430 2.0 Array)   1435371_x_at (Mouse Genome 430 2.0 Array)   1449081_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034172
NCBI entrez gene - 104158     See in Manteia.
MGI - MGI:2148202
RefSeq - NM_053200
RefSeq Peptide - NP_444430
swissprot - Q8VCT4
Ensembl - ENSMUSG00000056973
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ces2ENSDARG00000041569Danio rerio
 ces3ENSDARG00000041595Danio rerio
 si:ch211-93f2.1ENSDARG00000104818Danio rerio
 si:ch211-93f2.1ENSDARG00000101726Danio rerio
 ENSGALG00000040558Gallus gallus
 ENSGALG00000034990Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ces1e / Q64176 / Carboxylesterase 1E ENSMUSG0000006195976
Ces1g / Q8VCC2 / Liver carboxylesterase 1 ENSMUSG0000005707476
Ces1a / carboxylesterase 1A / CES1* / P23141* / carboxylesterase 1*ENSMUSG0000007104773
Ces1h / carboxylesterase 1HENSMUSG0000007415672
Ces1b / carboxylesterase 1BENSMUSG0000007896471
Ces1f / Q91WU0 / Carboxylesterase 1F ENSMUSG0000003172570
Ces1c / P23953 / Carboxylesterase 1C ENSMUSG0000005740069
Ces2b / carboxyesterase 2B / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000005009745
Ces2e / Q8BK48 / Pyrethroid hydrolase Ces2e / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000003188645
Ces2g / carboxylesterase 2G / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000003187744
Ces2c / Q91WG0 / Acylcarnitine hydrolase / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000006182544
Ces2a / Q8QZR3 / Pyrethroid hydrolase Ces2a / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000005573044
Ces2f / carboxylesterase 2F / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000006282644
Ces4a / Q8R0W5 / Carboxylesterase 4A / Q5XG92*ENSMUSG0000006056043
Ces2h / carboxylesterase 2H / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000009181343
Ces5a / Q6AW46 / Carboxylesterase 5A / Q6NT32*ENSMUSG0000005801942
Ces3a / Q63880 / Carboxylesterase 3A / CES3* / Q6UWW8* / carboxylesterase 3*ENSMUSG0000006992239
Ces3b / Q8VCU1 / Carboxylesterase 3B / CES3* / Q6UWW8* / carboxylesterase 3*ENSMUSG0000006218139
Nlgn2 / Q69ZK9 / Neuroligin-2 / Q8NFZ4*ENSMUSG0000005179032
Nlgn3 / Q8BYM5 / Neuroligin-3 / Q9NZ94*ENSMUSG0000003130232


Protein motifs (from Interpro)
Interpro ID Name
 IPR002018  Carboxylesterase, type B
 IPR019819  Carboxylesterase type B, conserved site
 IPR019826  Carboxylesterase type B, active site
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006637 acyl-CoA metabolic process TAS
 biological_processGO:0006695 cholesterol biosynthetic process ISO
 biological_processGO:0009636 response to toxic substance TAS
 biological_processGO:0016042 lipid catabolic process IDA
 biological_processGO:0019626 short-chain fatty acid catabolic process IDA
 biological_processGO:0030855 epithelial cell differentiation ISO
 biological_processGO:0034379 very-low-density lipoprotein particle assembly IMP
 biological_processGO:0046464 acylglycerol catabolic process IDA
 biological_processGO:0051791 medium-chain fatty acid metabolic process ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004771 sterol esterase activity ISO
 molecular_functionGO:0004806 triglyceride lipase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030339 fatty-acyl-ethyl-ester synthase activity IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0003976 decreased circulating VLDL triglyceride level "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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