ENSMUSG00000023328


Mus musculus

Features
Gene ID: ENSMUSG00000023328
  
Biological name :Ache
  
Synonyms : acetylcholinesterase / Ache / P21836
  
Possible biological names infered from orthology : acetylcholinesterase (Cartwright blood group) / P22303
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 137287519
Gene end: 137294466
  
Corresponding Affymetrix probe sets: 10526559 (MoGene1.0st)   1422635_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123248
Ensembl peptide - ENSMUSP00000142427
Ensembl peptide - ENSMUSP00000123295
Ensembl peptide - ENSMUSP00000024099
Ensembl peptide - ENSMUSP00000083097
Ensembl peptide - ENSMUSP00000117452
Ensembl peptide - ENSMUSP00000119813
Ensembl peptide - ENSMUSP00000121378
NCBI entrez gene - 11423     See in Manteia.
MGI - MGI:87876
RefSeq - XM_006504547
RefSeq - XM_006504548
RefSeq - NM_001290010
RefSeq - NM_009599
RefSeq Peptide - NP_001276939
RefSeq Peptide - NP_033729
swissprot - P21836
swissprot - Q543Z1
swissprot - D3Z064
swissprot - A0A0G2JDM6
Ensembl - ENSMUSG00000023328
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acheENSDARG00000031796Danio rerio
 ACHEENSG00000087085Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bche / Q03311 / Cholinesterase / P06276* / butyrylcholinesterase*ENSMUSG0000002779249
Nlgn3 / Q8BYM5 / Neuroligin-3 / Q9NZ94*ENSMUSG0000003130235
Nlgn1 / Q99K10 / Neuroligin-1 / Q8N2Q7*ENSMUSG0000006388733
Ces2g / carboxylesterase 2G / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000003187733
Nlgn2 / Q69ZK9 / Neuroligin-2 / Q8NFZ4*ENSMUSG0000005179033
Ces2e / Q8BK48 / Pyrethroid hydrolase Ces2e / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000003188632
Ces2a / Q8QZR3 / Pyrethroid hydrolase Ces2a / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000005573032
Ces2f / carboxylesterase 2F / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000006282632
Ces2c / Q91WG0 / Acylcarnitine hydrolase / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000006182531
Ces2b / carboxyesterase 2B / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000005009730
Ces4a / Q8R0W5 / Carboxylesterase 4A / Q5XG92*ENSMUSG0000006056030
Ces2h / carboxylesterase 2H / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000009181330
Ces5a / Q6AW46 / Carboxylesterase 5A / Q6NT32*ENSMUSG0000005801929
Ces1g / Q8VCC2 / Liver carboxylesterase 1 ENSMUSG0000005707428
Ces1b / carboxylesterase 1BENSMUSG0000007896428
Ces3a / Q63880 / Carboxylesterase 3A / CES3* / Q6UWW8* / carboxylesterase 3*ENSMUSG0000006992228
Ces3b / Q8VCU1 / Carboxylesterase 3B / CES3* / Q6UWW8* / carboxylesterase 3*ENSMUSG0000006218128
Ces1h / carboxylesterase 1HENSMUSG0000007415628
Ces1e / Q64176 / Carboxylesterase 1E ENSMUSG0000006195928
Ces1c / P23953 / Carboxylesterase 1C ENSMUSG0000005740028


Protein motifs (from Interpro)
Interpro ID Name
 IPR000997  Cholinesterase
 IPR002018  Carboxylesterase, type B
 IPR014788  Acetylcholinesterase, tetramerisation domain
 IPR019819  Carboxylesterase type B, conserved site
 IPR019826  Carboxylesterase type B, active site
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001919 regulation of receptor recycling IMP
 biological_processGO:0002076 osteoblast development IEA
 biological_processGO:0006581 acetylcholine catabolic process ISO
 biological_processGO:0007155 cell adhesion ISO
 biological_processGO:0031623 receptor internalization IMP
 biological_processGO:0042135 neurotransmitter catabolic process IEA
 biological_processGO:0045212 neurotransmitter receptor biosynthetic process IMP
 biological_processGO:0051262 protein tetramerization IDA
 biological_processGO:0060041 retina development in camera-type eye IMP
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005605 basal lamina IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0045202 synapse ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0003990 acetylcholinesterase activity ISO
 molecular_functionGO:0004104 cholinesterase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding ISO
 molecular_functionGO:0016787 hydrolase activity ISO
 molecular_functionGO:0017171 serine hydrolase activity ISO
 molecular_functionGO:0042166 acetylcholine binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0043236 laminin binding ISO
 molecular_functionGO:0043621 protein self-association IPI
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Neurotransmitter clearance
Synthesis of PC
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000054 delayed ear emergence "late onset of the growth of the outer ear" [J:49421]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Achetm1.1Pata/Achetm1.1Pata
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Achetm2Pata/Achetm2Pata
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Achetm1.1Hssh/Achetm1.1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Rbx1Gt(XB674)Byg/Rbx1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6 * FVB

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Achetm1.1Pata/Achetm1.1Pata
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Achetm2Pata/Achetm2Pata
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6 * FVB

Allelic Composition: Achetm4.1Pata/Achetm4.1Pata
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6 * FVB * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Achetm1.1Pata/Achetm1.1Pata
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Achetm4Pata/Achetm4Pata,Prima1tm1Vebe/Prima1tm1Vebe
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Rbx1Gt(XB674)Byg/Rbx1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6 * FVB

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
Show

Allelic Composition: Rbx1Gt(XB674)Byg/Rbx1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6 * FVB

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Paxip1tm1Gdr/Paxip1tm1Gdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Achetm4Pata/Achetm4Pata,Prima1tm1Vebe/Prima1tm1Vebe
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Paxip1tm1Gdr/Paxip1tm1Gdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6 * FVB

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Achetm1.1Pata/Achetm1.1Pata
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rbx1Gt(XB674)Byg/Rbx1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Paxip1tm1Gdr/Paxip1tm1Gdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002327 abnormal respiratory function "anomaly in any measure of the processes involved in respiration" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Achetm1.1Pata/Achetm1.1Pata
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ

 MP:0003492 abnormal involuntary movement "anomalies in movements that occur independent of planning (eg. reflexive behavior)" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ

 MP:0004183 abnormal sympathetic nervous system physiology "anomaly in the function of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Achetm1.1Hssh/Achetm1.1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005176 eyelids fail to open "eyes remain shut throughout life" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Achetm1.1Pata/Achetm1.1Pata
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Achetm1.1Hssh/Achetm1.1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Achetm1.1Pata/Achetm1.1Pata
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ

 MP:0005575 increased pulmonary ventilation "greater than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Achetm1.1Pata/Achetm1.1Pata
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ

 MP:0005576 decreased pulmonary ventilation "less than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Achetm1.1Pata/Achetm1.1Pata
Genetic Background: involves: 129X1/SvJ

 MP:0005585 increased tidal volume "greater than the normal volume of air inspired or expired during each normal respiratory cycle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Achetm1.1Pata/Achetm1.1Pata
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ

 MP:0005586 decreased tidal volume "less than the normal volume of air inspired or expired during each normal respiratory cycle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Achetm1.1Pata/Achetm1.1Pata
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Achetm1.1Hssh/Achetm1.1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Achetm1.1Hssh/Achetm1.1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bchetm1Loc/Bche+
Genetic Background: involves: 129S1/Sv

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Achetm1.1Pata/Achetm1.1Pata
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Achetm1Loc/Achetm1Loc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Achetm1Loc/Achetm1Loc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6 * FVB

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Achetm4Pata/Achetm4Pata
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6 * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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