ENSDARG00000031796


Danio rerio

Features
Gene ID: ENSDARG00000031796
  
Biological name :ache
  
Synonyms : acetylcholinesterase / ache / Q9DDE3
  
Possible biological names infered from orthology : acetylcholinesterase (Cartwright blood group) / P21836 / P22303
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 26077153
Gene end: 26087807
  
Corresponding Affymetrix probe sets: Dr.15722.1.S1_at (Zebrafish Array)   NM_131846_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000052988
NCBI entrez gene - 114549     See in Manteia.
RefSeq - NM_131846
RefSeq Peptide - NP_571921
swissprot - B3DKL4
swissprot - Q9DDE3
ZFIN ID - ZDB-GENE-010906-1
Ensembl - ENSDARG00000031796
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ACHEENSG00000087085Homo sapiens
 AcheENSMUSG00000023328Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nlgn2b / neuroligin 2b / NLGN2* / Q8NFZ4* / neuroligin 2*ENSDARG0000007925133
nlgn4a / neuroligin 4a / NLGN4X* / Q8N0W4* / Q8NFZ3* / NLGN4Y* / neuroligin 4, Y-linked* / neuroligin 4, X-linked*ENSDARG0000007945532
nlgn1 / neuroligin 1 / Q8N2Q7* / Q99K10*ENSDARG0000007771032
nlgn4b / neuroligin 4b / NLGN4X* / Q8N0W4* / Q8NFZ3* / NLGN4Y* / neuroligin 4, Y-linked* / neuroligin 4, X-linked*ENSDARG0000007776132
nlgn2a / neuroligin 2a / NLGN2* / Q69ZK9* / Q8NFZ4* / neuroligin 2*ENSDARG0000007732932
nlgn3a / neuroligin 3a / NLGN3* / Q8BYM5* / Q9NZ94* / neuroligin 3*ENSDARG0000010478630
nlgn3b / neuroligin 3b / NLGN3* / Q8BYM5* / Q9NZ94* / neuroligin 3*ENSDARG0000006237630
cel.2 / carboxyl ester lipase, tandem duplicate 2 / CEL* / Q64285* / carboxyl ester lipase* / Bile salt-activated lipase *ENSDARG0000002982228
cel.1 / carboxyl ester lipase, tandem duplicate 1 / CEL* / Q64285* / carboxyl ester lipase* / Bile salt-activated lipase *ENSDARG0000001749026
ces3 / carboxylesterase 3 / CES1* / CES2* / Ces2h* / Ces2g* / Ces2f* / Ces2e* / Ces2c* / Ces2b* / Ces2a* / Ces1h* / Ces1g* / Ces1f* / Ces1a* / Ces1b* / Ces1c* / Ces1e* / Ces1d* / CES5A* / C...ENSDARG0000004159526
ces2 / carboxylesterase 2 (intestine, liver) / CES1* / CES3* / Ces2h* / Ces2g* / Ces2f* / Ces2e* / Ces2c* / Ces2b* / Ces2a* / Ces1h* / Ces1g* / Ces1f* / Ces1e* / Ces1a* / Ces1b* / Ces1d* / ...ENSDARG0000004156925
si:ch211-93f2.1 / CES1* / CES2* / CES3* / Ces2h* / Ces2g* / Ces2f* / Ces2e* / Ces2c* / Ces2b* / Ces2a* / Ces1h* / Ces1g* / Ces1f* / Ces1a* / Ces1b* / Ces1c* / Ces1e* / Ces1d* / CES5A* / CES...ENSDARG0000010172621
si:ch211-93f2.1 / CES1* / CES3* / CES2* / CES4A* / CES5A* / Q6NT32* / P23141* / Q5XG92* / Q6UWW8* / O00748* / carboxylesterase 1* / carboxylesterase 2* / carboxylesterase 3* / carboxylester...ENSDARG0000010481816


Protein motifs (from Interpro)
Interpro ID Name
 IPR000997  Cholinesterase
 IPR002018  Carboxylesterase, type B
 IPR014788  Acetylcholinesterase, tetramerisation domain
 IPR019819  Carboxylesterase type B, conserved site
 IPR019826  Carboxylesterase type B, active site
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001975 response to amphetamine IMP
 biological_processGO:0006581 acetylcholine catabolic process IMP
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0009749 response to glucose IDA
 biological_processGO:0030239 myofibril assembly IMP
 biological_processGO:0042135 neurotransmitter catabolic process IEA
 biological_processGO:0045471 response to ethanol IDA
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0050803 regulation of synapse structure or activity IMP
 biological_processGO:0071405 cellular response to methanol IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0003990 acetylcholinesterase activity IMP
 molecular_functionGO:0004104 cholinesterase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Neurotransmitter clearance
Synthesis of PC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000075 spinal cord spinal cord Rohon-Beard neuron apoptotic , abnormal
Show

 ZFA:0000135 notochord notochord damaged , abnormal
notochord quality , abnormal
Show

 ZFA:0000473 trunk musculature trunk musculature acetylcholine-gated channel complex position , abnormal
trunk musculature nuclear envelope shape , abnormal
trunk musculature nuclear envelope vacuolated , abnormal
trunk musculature sarcoplasm vacuolated , abnormal
trunk musculature myofibril decreased length , abnormal
trunk musculature myofibril disorganized , abnormal
trunk musculature contractility , abnormal
trunk musculature quality , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism paralysed , abnormal
whole organism movement behavioral quality , abnormal
whole organism viability , abnormal
Show

 ZFA:0001135 neural tube neural tube Rohon-Beard neuron apoptotic , abnormal
Show

 ZFA:0009052 motor neuron motor neuron axon decreased size , abnormal
motor neuron axon decreased thickness , abnormal
Show

 ZFA:0009114 muscle cell muscle cell acetylcholine-gated channel complex decreased size , abnormal
muscle cell acetylcholine-gated channel complex decreased amount , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell myosin filament decreased amount , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron dendrite decreased length , abnormal
Rohon-Beard neuron dendrite decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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