ENSMUSG00000021782


Mus musculus

Features
Gene ID: ENSMUSG00000021782
  
Biological name :Dlg5
  
Synonyms : Disks large homolog 5 / Dlg5 / E9Q9R9
  
Possible biological names infered from orthology : discs large MAGUK scaffold protein 5 / Q8TDM6
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: A3
Gene start: 24133953
Gene end: 24245920
  
Corresponding Affymetrix probe sets: 10418096 (MoGene1.0st)   1424198_at (Mouse Genome 430 2.0 Array)   1431186_at (Mouse Genome 430 2.0 Array)   1431187_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044852
Ensembl peptide - ENSMUSP00000127054
Ensembl peptide - ENSMUSP00000131986
Ensembl peptide - ENSMUSP00000128735
Ensembl peptide - ENSMUSP00000073367
Ensembl peptide - ENSMUSP00000087879
NCBI entrez gene - 71228     See in Manteia.
MGI - MGI:1918478
RefSeq - XM_006519560
RefSeq - XM_017316197
RefSeq - XM_017316202
RefSeq - XM_017316201
RefSeq - XM_017316200
RefSeq - XM_017316199
RefSeq - NM_001163513
RefSeq - NM_027726
RefSeq - XM_017316203
RefSeq - XM_017316198
RefSeq Peptide - NP_082002
RefSeq Peptide - NP_001156985
swissprot - E9Q9R9
swissprot - E9Q9I2
swissprot - F7BYL0
swissprot - F6Z115
swissprot - F6YZU5
swissprot - F6VMK9
Ensembl - ENSMUSG00000021782
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlg5aENSDARG00000074059Danio rerio
 dlg5b.1ENSDARG00000090949Danio rerio
 DLG5ENSGALG00000043018Gallus gallus
 DLG5ENSG00000151208Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tjp1 / P39447 / tight junction protein 1 / Q07157*ENSMUSG0000003051611
Tjp2 / Q9Z0U1 / Tight junction protein ZO-2 / Q9UDY2* / AL358113.1* / tight junction protein 2*ENSMUSG0000002481211
Dlg1 / Q811D0 / Disks large homolog 1 / Q12959* / discs large MAGUK scaffold protein 1*ENSMUSG0000002277010
Dlg2 / Q91XM9 / Disks large homolog 2 / Q15700* / discs large MAGUK scaffold protein 2*ENSMUSG0000005257210
Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*ENSMUSG0000000088110
Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*ENSMUSG000000208869
Tjp3 / tight junction protein 3 / O95049*ENSMUSG000000349179
Mpp7 / MAGUK p55 subfamily member 7 isoform 2 / Q5T2T1* / membrane palmitoylated protein 7*ENSMUSG000000574407
Mpp3 / membrane palmitoylated protein 3 / Q13368*ENSMUSG000000523737
Mpp5 / Q9JLB2 / membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) / Q8N3R9* / membrane palmitoylated protein 5*ENSMUSG000000211126
Cask / O70589 / Peripheral plasma membrane protein CASK / O14936* / calcium/calmodulin dependent serine protein kinase*ENSMUSG000000310126
Mpp4 / Q6P7F1 / MAGUK p55 subfamily member 4 / Q96JB8* / membrane palmitoylated protein 4*ENSMUSG000000795506
Mpp2 / Q9WV34 / Mus musculus membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) (Mpp2), transcript variant 1, mRNA. / Q14168* / membrane palmitoylated protein 2*ENSMUSG000000173145
Mpp6 / Q9JLB0 / membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) / Q9NZW5* / membrane palmitoylated protein 6*ENSMUSG000000383885
Mpp1 / P70290 / membrane protein, palmitoylated / Q00013* / membrane palmitoylated protein 1*ENSMUSG000000314024
Guk1 / guanylate kinase 1 / Q16774*ENSMUSG000000204442


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR006907  Domain of unknown function DUF622
 IPR008144  Guanylate kinase-like domain
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR011029  Death-like domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035537  Disks large homologue 5, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0030011 maintenance of cell polarity IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0030859 polarized epithelial cell differentiation IMP
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0035331 negative regulation of hippo signaling IMP
 biological_processGO:0035332 positive regulation of hippo signaling IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045176 apical protein localization IMP
 biological_processGO:0045186 zonula adherens assembly IMP
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IMP
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IMP
 biological_processGO:0051965 positive regulation of synapse assembly IMP
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IMP
 biological_processGO:0060999 positive regulation of dendritic spine development IMP
 biological_processGO:0071896 protein localization to adherens junction IMP
 biological_processGO:0072205 metanephric collecting duct development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0000826 abnormal third ventricle morphology "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0002653 abnormal ependyma morphology "malformation or absence of the cellular membrane that lines the brain ventricles and the central canal of the spinal cord" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0003588 ureter stenosis "abnormal narrowing or constriction of the ureter" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0004754 abnormal kidney collecting duct "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0005537 abnormal cerebral aqueduct "anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0011331 abnormal papillary duct morphology "any structural anomaly of the largest straight excretory ducts in the kidney medulla and papillae that are a continuation of the collecting tubules, and that open into the area cribosa" [ISBN:0-683-40008-8]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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