ENSGALG00000010412


Gallus gallus

Features
Gene ID: ENSGALG00000010412
  
Biological name :WWTR1
  
Synonyms : WW domain containing transcription regulator 1 / WWTR1
  
Possible biological names infered from orthology : Q9EPK5 / Q9GZV5
  
Species: Gallus gallus
  
Chr. number: 9
Strand: 1
Band:
Gene start: 23898460
Gene end: 23938545
  
Corresponding Affymetrix probe sets: GgaAffx.6578.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000016933
NCBI entrez gene - 100859902     See in Manteia.
RefSeq - XM_003641786
swissprot - F1NA37
Ensembl - ENSGALG00000010412
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wwtr1ENSDARG00000067719Danio rerio
 WWTR1ENSG00000018408Homo sapiens
 Wwtr1ENSMUSG00000027803Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YAP1 / transcriptional coactivator YAP1 / P46937* / P46938* / Yes associated protein 1*ENSGALG0000003815451


Protein motifs (from Interpro)
Interpro ID Name
 IPR001202  WW domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0017145 stem cell division IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032835 glomerulus development IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0035329 hippo signaling IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048762 mesenchymal cell differentiation IEA
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:0060390 regulation of SMAD protein signal transduction IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0060993 kidney morphogenesis IEA
 biological_processGO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo
YAP1- and WWTR1 (TAZ)-stimulated gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007952 AMOT / angiomotin / Q4VCS5* / Q8VHG2*  / complex / reaction
 ENSGALG00000002661 YWHAE / Q5ZMT0 / 14-3-3 protein epsilon / P62259* / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon* / tyrosine 3-monooxygenase/tryptophan 5-monoox...  / reaction / complex
 ENSGALG00000005415 TEAD1 / TEA domain transcription factor 1 / P28347* / TEA domain family member 1*  / reaction / complex
 ENSGALG00000014342 TEAD4 / P48984 / Transcriptional enhancer factor TEF-3 / Q15561* / TEA domain family member 4* / TEA domain transcription factor 4*  / reaction / complex
 ENSGALG00000014184 SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000043513 TEAD3 / TEA domain transcription factor 3 / P70210* / Q99594* / TEA domain family member 3*  / reaction / complex
 ENSGALG00000036001 SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000015109 TJP2 / tight junction protein ZO-2 / Q9Z0U1* / Q9UDY2* / AL358113.1* / tight junction protein 2*  / reaction / complex
 ENSGALG00000012386 LATS1 / large tumor suppressor kinase 1 / O95835* / Q8BYR2* / Serine/threonine-protein kinase LATS1 *  / reaction
 ENSGALG00000017208 AMOTL1 / angiomotin like 1 / Q8IY63* / Q9D4H4* / Angiomotin-like protein 1 *  / reaction / complex
 ENSGALG00000042552 TJP1 / tight junction protein 1 / P39447* / Q07157*  / complex / reaction






 

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