ENSGALG00000042552


Gallus gallus

Features
Gene ID: ENSGALG00000042552
  
Biological name :TJP1
  
Synonyms : tight junction protein 1 / TJP1
  
Possible biological names infered from orthology : P39447 / Q07157
  
Species: Gallus gallus
  
Chr. number: 10
Strand: -1
Band:
Gene start: 5963381
Gene end: 6117896
  
Corresponding Affymetrix probe sets: Gga.20045.1.S1_s_at (Chicken Array)   GgaAffx.26072.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044872
Ensembl peptide - ENSGALP00000057787
Ensembl peptide - ENSGALP00000051371
Ensembl peptide - ENSGALP00000049930
NCBI entrez gene - 415388     See in Manteia.
RefSeq - XM_015278981
RefSeq - XM_015278977
RefSeq - XM_015278978
RefSeq - XM_015278979
RefSeq - XM_015278980
RefSeq - XM_015278975
RefSeq - XM_015278976
swissprot - A0A1D5PF09
swissprot - A0A1D5PB11
swissprot - A0A1D5NWX9
swissprot - A0A1D5PXU0
Ensembl - ENSGALG00000042552
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tjp1aENSDARG00000077506Danio rerio
 tjp1bENSDARG00000079374Danio rerio
 TJP1ENSG00000104067Homo sapiens
 Tjp1ENSMUSG00000030516Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TJP2 / tight junction protein ZO-2 / Q9Z0U1* / Q9UDY2* / AL358113.1* / tight junction protein 2*ENSGALG0000001510929
TJP3 / tight junction protein 3 / O95049*ENSGALG0000000074822
DLG5 / discs large MAGUK scaffold protein 5 / E9Q9R9* / Q8TDM6* / Disks large homolog 5 *ENSGALG0000004301811
DLG3 / discs large MAGUK scaffold protein 3 / P70175* / Q92796* / Disks large homolog 3 *ENSGALG000000419009
DLG1 / discs large MAGUK scaffold protein 1 / Q12959* / Q811D0* / Disks large homolog 1 *ENSGALG000000069089
CASK / calcium/calmodulin dependent serine protein kinase / O14936* / O70589* / Peripheral plasma membrane protein CASK *ENSGALG000000424006
MPP4 / membrane palmitoylated protein 4 / Q6P7F1* / Q96JB8* / MAGUK p55 subfamily member 4 *ENSGALG000000083986
MPP3 / membrane palmitoylated protein 3 / Q13368*ENSGALG000000425216
MPP5 / membrane palmitoylated protein 5 / Q8N3R9* / Q9JLB2* / membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)*ENSGALG000000095816
MPP2 / membrane palmitoylated protein 2 / Q14168* / Q9WV34* / Mus musculus membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) (Mpp2), transcript variant 1, mRNA.*ENSGALG000000355806
MPP6 / membrane palmitoylated protein 6 / Q9JLB0* / Q9NZW5* / membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)*ENSGALG000000109885
MPP7 / membrane palmitoylated protein 7 / Q5T2T1* / MAGUK p55 subfamily member 7 isoform 2 *ENSGALG000000074084
ENSGALG000000429924
MPP1 / Q5ZJ00 / 55 kDa erythrocyte membrane protein / P70290* / Q00013* / membrane protein, palmitoylated* / membrane palmitoylated protein 1*ENSGALG000000050714
GUK1 / guanylate kinase 1 / Q16774*ENSGALG000000053362
DLG2* / Q15700* / Q91XM9* / Disks large homolog 2 * / discs large MAGUK scaffold protein 2*ENSGALG000000412252


Protein motifs (from Interpro)
Interpro ID Name
 IPR000906  ZU5 domain
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR005417  Tight junction protein ZO
 IPR005418  Tight junction protein ZO-1
 IPR008144  Guanylate kinase-like domain
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001825 blastocyst formation IEA
 biological_processGO:0007605 sensory perception of sound IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016327 apicolateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0046581 intercellular canaliculus IEA
 cellular_componentGO:0070160 occluding junction IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0071253 connexin binding IEA


Pathways (from Reactome)
Pathway description
c-src mediated regulation of Cx43 function and closure of gap junctions
Signaling by Hippo
Apoptotic cleavage of cell adhesion proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000010638 CASP3 / caspase 3 / P42574* / P70677* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*  / reaction
 ENSGALG00000010412 WWTR1 / WW domain containing transcription regulator 1 / Q9EPK5* / Q9GZV5*  / complex / reaction
 ENSGALG00000042552 TJP1 / tight junction protein 1 / P39447* / Q07157*  / complex






 

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