ENSGALG00000006908


Gallus gallus

Features
Gene ID: ENSGALG00000006908
  
Biological name :DLG1
  
Synonyms : discs large MAGUK scaffold protein 1 / DLG1
  
Possible biological names infered from orthology : Disks large homolog 1 / Q12959 / Q811D0
  
Species: Gallus gallus
  
Chr. number: 9
Strand: -1
Band:
Gene start: 12507255
Gene end: 12640489
  
Corresponding Affymetrix probe sets: Gga.12895.1.S1_at (Chicken Array)   GgaAffx.21480.1.S1_at (Chicken Array)   GgaAffx.21480.1.S2_at (Chicken Array)   GgaAffx.22095.1.S1_s_at (Chicken Array)   GgaAffx.4321.2.S1_at (Chicken Array)   GgaAffx.4321.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000011181
Ensembl peptide - ENSGALP00000056070
Ensembl peptide - ENSGALP00000048011
Ensembl peptide - ENSGALP00000046618
Ensembl peptide - ENSGALP00000046332
NCBI entrez gene - 424890     See in Manteia.
RefSeq - XM_422701
RefSeq - XM_015291609
RefSeq - XM_015291610
RefSeq - XM_015291611
RefSeq - XM_015291612
RefSeq - XM_015291613
RefSeq - XM_003641763
RefSeq - XM_003641764
RefSeq - XM_004943320
RefSeq - XM_004943321
RefSeq - XM_004943322
RefSeq - XM_015291605
RefSeq - XM_015291606
RefSeq - XM_015291607
RefSeq - XM_015291608
swissprot - E1BT38
swissprot - A0A1D5PT29
swissprot - A0A1D5P5N9
swissprot - A0A1D5P1S9
swissprot - A0A1D5P102
Ensembl - ENSGALG00000006908
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlg1ENSDARG00000009677Danio rerio
 dlg1lENSDARG00000102216Danio rerio
 DLG1ENSG00000075711Homo sapiens
 Dlg1ENSMUSG00000022770Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DLG3 / discs large MAGUK scaffold protein 3 / P70175* / Q92796* / Disks large homolog 3 *ENSGALG0000004190056
ENSGALG0000004299228
DLG5 / discs large MAGUK scaffold protein 5 / E9Q9R9* / Q8TDM6* / Disks large homolog 5 *ENSGALG0000004301819
TJP1 / tight junction protein 1 / P39447* / Q07157*ENSGALG0000004255217
MPP5 / membrane palmitoylated protein 5 / Q8N3R9* / Q9JLB2* / membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)*ENSGALG0000000958117
TJP3 / tight junction protein 3 / O95049*ENSGALG0000000074816
TJP2 / tight junction protein ZO-2 / Q9Z0U1* / Q9UDY2* / AL358113.1* / tight junction protein 2*ENSGALG0000001510916
MPP2 / membrane palmitoylated protein 2 / Q14168* / Q9WV34* / Mus musculus membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) (Mpp2), transcript variant 1, mRNA.*ENSGALG0000003558016
MPP4 / membrane palmitoylated protein 4 / Q6P7F1* / Q96JB8* / MAGUK p55 subfamily member 4 *ENSGALG0000000839816
CASK / calcium/calmodulin dependent serine protein kinase / O14936* / O70589* / Peripheral plasma membrane protein CASK *ENSGALG0000004240016
MPP6 / membrane palmitoylated protein 6 / Q9JLB0* / Q9NZW5* / membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)*ENSGALG0000001098815
MPP3 / membrane palmitoylated protein 3 / Q13368*ENSGALG0000004252115
MPP1 / Q5ZJ00 / 55 kDa erythrocyte membrane protein / P70290* / Q00013* / membrane protein, palmitoylated* / membrane palmitoylated protein 1*ENSGALG0000000507113
DLG2* / Q15700* / Q91XM9* / Disks large homolog 2 * / discs large MAGUK scaffold protein 2*ENSGALG0000004122510
MPP7 / membrane palmitoylated protein 7 / Q5T2T1* / MAGUK p55 subfamily member 7 isoform 2 *ENSGALG000000074089
GUK1 / guanylate kinase 1 / Q16774*ENSGALG000000053366


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR004172  L27 domain
 IPR008144  Guanylate kinase-like domain
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR015143  L27-1
 IPR016313  Disks large 1-like
 IPR019583  PDZ-associated domain of NMDA receptors
 IPR019590  Disks large homologue 1, N-terminal PEST domain
 IPR020590  Guanylate kinase, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001771 immunological synapse formation IEA
 biological_processGO:0001935 endothelial cell proliferation IEA
 biological_processGO:0002088 lens development in camera-type eye IEA
 biological_processGO:0002369 T cell cytokine production IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0008104 protein localization IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0030432 peristalsis IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0030953 astral microtubule organization IEA
 biological_processGO:0031579 membrane raft organization IEA
 biological_processGO:0031641 regulation of myelination IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0034629 cellular protein-containing complex localization IEA
 biological_processGO:0042110 T cell activation IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0042982 amyloid precursor protein metabolic process IEA
 biological_processGO:0043113 receptor clustering IBA
 biological_processGO:0043268 positive regulation of potassium ion transport IEA
 biological_processGO:0043622 cortical microtubule organization IEA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IBA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0046037 GMP metabolic process IEA
 biological_processGO:0046710 GDP metabolic process IEA
 biological_processGO:0048608 reproductive structure development IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 biological_processGO:0048729 tissue morphogenesis IEA
 biological_processGO:0048745 smooth muscle tissue development IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0051660 establishment of centrosome localization IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0060022 hard palate development IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070830 bicellular tight junction assembly IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0097120 receptor localization to synapse IBA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:0098911 regulation of ventricular cardiac muscle cell action potential IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1903286 regulation of potassium ion import IEA
 biological_processGO:1903753 negative regulation of p38MAPK cascade IEA
 biological_processGO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IEA
 biological_processGO:1903764 regulation of potassium ion export across plasma membrane IEA
 cellular_componentGO:0001772 immunological synapse IEA
 cellular_componentGO:0005605 basal lamina IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IBA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IBA
 cellular_componentGO:0016323 basolateral plasma membrane IBA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031253 cell projection membrane IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0033268 node of Ranvier IEA
 cellular_componentGO:0035748 myelin sheath abaxonal region IEA
 cellular_componentGO:0043219 lateral loop IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IBA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097025 MPP7-DLG1-LIN7 complex IEA
 molecular_functionGO:0004385 guanylate kinase activity IBA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0015459 potassium channel regulator activity IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IBA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0097016 L27 domain binding IEA


Pathways (from Reactome)
Pathway description
Activation of Ca-permeable Kainate Receptor
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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