ENSDARG00000009677


Danio rerio

Features
Gene ID: ENSDARG00000009677
  
Biological name :dlg1
  
Synonyms : discs, large homolog 1 (Drosophila) / dlg1 / Q5PYH6
  
Possible biological names infered from orthology : discs large MAGUK scaffold protein 1 / Disks large homolog 1 / Q12959 / Q811D0
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 29860776
Gene end: 30082922
  
Corresponding Affymetrix probe sets: Dr.7949.1.S1_at (Zebrafish Array)   NM_199526_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000036537
Ensembl peptide - ENSDARP00000140987
Ensembl peptide - ENSDARP00000134848
NCBI entrez gene - 114446     See in Manteia.
RefSeq - NM_199526
RefSeq Peptide - NP_955820
swissprot - E7FAT1
swissprot - A0A0R4IVD3
swissprot - Q5PYH6
ZFIN ID - ZDB-GENE-010724-8
Ensembl - ENSDARG00000009677
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DLG1ENSGALG00000006908Gallus gallus
 DLG1ENSG00000075711Homo sapiens
 Dlg1ENSMUSG00000022770Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dlg1l / Q5PYH5 / discs, large (Drosophila) homolog 1, like / DLG1* / Q12959* / Q811D0* / Disks large homolog 1 * / discs large MAGUK scaffold protein 1*ENSDARG0000010221673
dlg2 / discs, large homolog 2 (Drosophila) / Q15700* / Q91XM9* / Disks large homolog 2 * / discs large MAGUK scaffold protein 2*ENSDARG0000009932365
dlg3 / discs, large homolog 3 (Drosophila) / P70175* / Q92796* / Disks large homolog 3 * / discs large MAGUK scaffold protein 3*ENSDARG0000007679660
dlg4a / discs, large homolog 4a (Drosophila) / DLG4* / P78352* / discs large MAGUK scaffold protein 4*ENSDARG0000004192655
dlg4b / discs, large homolog 4b (Drosophila)ENSDARG0000003938536
dlg5a / discs, large homolog 5a (Drosophila) / DLG5* / E9Q9R9* / Q8TDM6* / Disks large homolog 5 * / discs large MAGUK scaffold protein 5*ENSDARG0000007405920
dlg5b.1 / discs, large homolog 5b (Drosophila), tandem duplicate 1 / DLG5* / E9Q9R9* / Q8TDM6* / Disks large homolog 5 * / discs large MAGUK scaffold protein 5*ENSDARG0000009094919
tjp1a / tight junction protein 1a / TJP1* / P39447* / Q07157* / tight junction protein 1*ENSDARG0000007750618
tjp2b / tight junction protein 2b (zona occludens 2) / TJP2* / Q9UDY2* / Q9Z0U1* / AL358113.1* / tight junction protein 2* / Tight junction protein ZO-2 *ENSDARG0000002344317
mpp5a / membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5) / MPP5* / Q8N3R9* / Q9JLB2* / membrane palmitoylated protein 5* / membrane protein, palmitoylated 5 (MAGUK p55 subf...ENSDARG0000000627217
tjp2a / tight junction protein 2a (zona occludens 2) / TJP2* / Q9UDY2* / Q9Z0U1* / AL358113.1* / tight junction protein 2* / Tight junction protein ZO-2 *ENSDARG0000006330917
mpp7a / Q6P0D7 / membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7) / MPP7* / Q5T2T1* / membrane palmitoylated protein 7* / MAGUK p55 subfamily member 7 isoform 2 *ENSDARG0000010247017
tjp1b / tight junction protein 1b / TJP1* / P39447* / Q07157* / tight junction protein 1*ENSDARG0000007937417
mpp3b / membrane protein, palmitoylated 3b (MAGUK p55 subfamily member 3) / MPP3* / Q13368* / membrane palmitoylated protein 3*ENSDARG0000006266716
mpp3a / membrane protein, palmitoylated 3a (MAGUK p55 subfamily member 3) / MPP3* / Q13368* / membrane palmitoylated protein 3*ENSDARG0000001518416
mpp4a / membrane protein, palmitoylated 4a (MAGUK p55 subfamily member 4) / MPP4* / Q6P7F1* / Q96JB8* / MAGUK p55 subfamily member 4 * / membrane palmitoylated protein 4*ENSDARG0000005822216
mpp6b / membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6) / MPP6* / Q9JLB0* / Q9NZW5* / membrane palmitoylated protein 6* / membrane protein, palmitoylated 6 (MAGUK p55 subf...ENSDARG0000002976116
caska / calcium/calmodulin-dependent serine protein kinase a / CASK* / O70589* / O14936* / Peripheral plasma membrane protein CASK * / calcium/calmodulin dependent serine protein kinase*ENSDARG0000005980916
mpp2b / membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2) / MPP2* / Q14168* / Q9WV34* / membrane palmitoylated protein 2* / Mus musculus membrane protein, palmitoylated 2 (M...ENSDARG0000001095715
tjp3 / tight junction protein 3 / O95049*ENSDARG0000000290915


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR004172  L27 domain
 IPR008144  Guanylate kinase-like domain
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR015143  L27-1
 IPR016313  Disks large 1-like
 IPR019583  PDZ-associated domain of NMDA receptors
 IPR019590  Disks large homologue 1, N-terminal PEST domain
 IPR020590  Guanylate kinase, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001935 endothelial cell proliferation ISS
 biological_processGO:0007015 actin filament organization ISS
 biological_processGO:0007268 chemical synaptic transmission NAS
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0030866 cortical actin cytoskeleton organization ISS
 biological_processGO:0043113 receptor clustering IBA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IBA
 biological_processGO:0045930 negative regulation of mitotic cell cycle ISS
 biological_processGO:0046037 GMP metabolic process IEA
 biological_processGO:0046710 GDP metabolic process IEA
 biological_processGO:0050808 synapse organization NAS
 biological_processGO:0097120 receptor localization to synapse IBA
 biological_processGO:0098609 cell-cell adhesion ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IBA
 cellular_componentGO:0014069 postsynaptic density IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane ISS
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045211 postsynaptic membrane IBA
 molecular_functionGO:0004385 guanylate kinase activity IBA
 molecular_functionGO:0019901 protein kinase binding ISS
 molecular_functionGO:0019902 phosphatase binding ISS
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IBA


Pathways (from Reactome)
Pathway description
Activation of Ca-permeable Kainate Receptor
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000077489 lrfn2b / leucine rich repeat and fibronectin type III domain containing 2b / LRFN2* / Q80TG9* / Q9ULH4* / leucine rich repeat and fibronectin type III domain containing 2* / Leucine-rich re...  / reaction / complex
 ENSDARG00000055132 lrfn4a / leucine rich repeat and fibronectin type III domain containing 4a / LRFN4* / Q6PJG9* / Q80XU8* / leucine rich repeat and fibronectin type III domain containing 4* / Leucine-rich re...  / complex / reaction
 ENSDARG00000106248 BX548062.1 / LRFN2* / Q9ULH4* / leucine rich repeat and fibronectin type III domain containing 2*  / complex / reaction






 

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