ENSMUSG00000024290


Mus musculus

Features
Gene ID: ENSMUSG00000024290
  
Biological name :Rock1
  
Synonyms : P70335 / Rho-associated protein kinase 1 / Rock1
  
Possible biological names infered from orthology : Q13464 / Rho associated coiled-coil containing protein kinase 1
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: A1
Gene start: 10064401
Gene end: 10181792
  
Corresponding Affymetrix probe sets: 10457429 (MoGene1.0st)   1423444_at (Mouse Genome 430 2.0 Array)   1423445_at (Mouse Genome 430 2.0 Array)   1441162_at (Mouse Genome 430 2.0 Array)   1450994_at (Mouse Genome 430 2.0 Array)   1460729_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069549
NCBI entrez gene - 19877     See in Manteia.
MGI - MGI:107927
RefSeq - NM_009071
RefSeq - XM_006525725
RefSeq Peptide - NP_033097
swissprot - P70335
Ensembl - ENSMUSG00000024290
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rock1ENSDARG00000058993Danio rerio
 ROCK1ENSGALG00000014922Gallus gallus
 ROCK1ENSG00000067900Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rock2 / Rho associated coiled-coil containing protein kinase 2 / O75116*ENSMUSG0000002058065
Q7TT50 / Cdc42bpb / CDC42 binding protein kinase beta / Q9Y5S2*ENSMUSG0000002127928
Q3UU96 / Cdc42bpa / Serine/threonine-protein kinase MRCK alpha / Q5VT25* / CDC42 binding protein kinase alpha*ENSMUSG0000002649027
Q80UW5 / Cdc42bpg / Serine/threonine-protein kinase MRCK gamma / Q6DT37* / CDC42 binding protein kinase gamma*ENSMUSG0000002476925
Cit / citron rho-interacting serine/threonine kinase / O14578*ENSMUSG0000002951625
Dmpk / P54265 / Myotonin-protein kinase / Q09013* / DM1 protein kinase*ENSMUSG0000003040915
Stk38 / Q91VJ4 / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA. / Q15208* / serine/threonine kinase 38*ENSMUSG0000002400612
Lats2 / Q7TSJ6 / Serine/threonine-protein kinase LATS2 / Q9NRM7* / large tumor suppressor kinase 2*ENSMUSG0000002195912
Q7TSE6 / Stk38l / Mus musculus serine/threonine kinase 38 like (Stk38l), transcript variant 2, mRNA. / Q9Y2H1* / serine/threonine kinase 38 like*ENSMUSG0000000163012
Lats1 / Q8BYR2 / Serine/threonine-protein kinase LATS1 / O95835* / large tumor suppressor kinase 1*ENSMUSG0000004002112
Lats2 / Q9NRM7* / large tumor suppressor kinase 2*ENSMUSG000001149428


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR015008  Rho binding domain
 IPR017441  Protein kinase, ATP binding site
 IPR020684  Rho-associated protein kinase 1/2
 IPR029876  Rho-associated protein kinase 1
 IPR037310  Rho-associated protein kinase 1, HR1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003383 apical constriction IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007266 Rho protein signal transduction ISO
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0022614 membrane to membrane docking IEA
 biological_processGO:0030036 actin cytoskeleton organization IGI
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032060 bleb assembly IMP
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0032970 regulation of actin filament-based process IGI
 biological_processGO:0035509 negative regulation of myosin-light-chain-phosphatase activity IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0045616 regulation of keratinocyte differentiation IEA
 biological_processGO:0045664 regulation of neuron differentiation IEA
 biological_processGO:0050900 leukocyte migration IEA
 biological_processGO:0050901 leukocyte tethering or rolling IEA
 biological_processGO:0051451 myoblast migration IMP
 biological_processGO:0051492 regulation of stress fiber assembly IEA
 biological_processGO:0051493 regulation of cytoskeleton organization IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IMP
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0140058 neuron projection arborization IEA
 biological_processGO:1900223 positive regulation of amyloid-beta clearance IEA
 biological_processGO:1900242 regulation of synaptic vesicle endocytosis IEA
 biological_processGO:1902430 negative regulation of amyloid-beta formation IEA
 biological_processGO:1902992 negative regulation of amyloid precursor protein catabolic process IEA
 biological_processGO:1903140 regulation of establishment of endothelial barrier IEA
 biological_processGO:1903347 negative regulation of bicellular tight junction assembly IEA
 biological_processGO:2000114 regulation of establishment of cell polarity IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0032059 bleb IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0106003 amyloid-beta complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0017049 GTP-Rho binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
EPHB-mediated forward signaling
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKs
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Agrptm1(cre)Lowl/Agrp+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Agrptm1(cre)Lowl/Agrp+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0001264 increased body size "larger than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

Allelic Composition: Rock1tm1b(NCOM)Mfgc/Rock1tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Rock1tm1b(NCOM)Mfgc/Tcp

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005251 blepharitis "inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005260 ocular hypotension "abnormally low intraocular pressure" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J

Allelic Composition: Rock1tm1.2Itl/Rock1tm1.2Itl
Genetic Background: Not Specified

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0009288 increased epididymal fat pad weight 
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Agrptm1(cre)Lowl/Agrp+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0009298 increased mesenteric fat pad weight 
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Agrptm1(cre)Lowl/Agrp+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0009302 increased renal fat pad weight 
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Agrptm1(cre)Lowl/Agrp+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Agrptm1(cre)Lowl/Agrp+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011103 partial embryonic lethality at implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at the point of implantation (Mus: E4.5)" [MGI:csmith]
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Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: FVB.129S7-Rock1tm1Leiw

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Rock1tm1b(NCOM)Mfgc/Rock1tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Rock1tm1b(NCOM)Mfgc/Tcp

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0011369 increased renal glomerulus apoptosis "increase in the number of cells of the kidney glomerulus undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / reaction
 ENSMUSG00000044813 Shb / Q6PD21 / SH2 domain-containing adapter protein B / Q15464* / AL138752.2* / SH2 domain containing adaptor protein B*  / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000002233 Rhoc / Q62159 / Rho-related GTP-binding protein RhoC / P08134* / ras homolog family member C*  / reaction / complex
 ENSMUSG00000054364 Rhob / P62746 / ras homolog family member B / P62745*  / reaction / complex
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / reaction
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / reaction
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction / complex
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

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