ENSMUSG00000024006


Mus musculus

Features
Gene ID: ENSMUSG00000024006
  
Biological name :Stk38
  
Synonyms : Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA. / Q91VJ4 / Stk38
  
Possible biological names infered from orthology : Q15208 / serine/threonine kinase 38
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 28970885
Gene end: 29007945
  
Corresponding Affymetrix probe sets: 10449527 (MoGene1.0st)   1416252_at (Mouse Genome 430 2.0 Array)   1431303_at (Mouse Genome 430 2.0 Array)   1439938_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000009138
Ensembl peptide - ENSMUSP00000113657
NCBI entrez gene - 106504     See in Manteia.
MGI - MGI:2442572
RefSeq - XM_017317194
RefSeq - NM_001357173
RefSeq - NM_134115
RefSeq - XM_006523386
RefSeq - XM_011246232
RefSeq - XM_011246233
RefSeq - XM_006523385
RefSeq Peptide - NP_598876
RefSeq Peptide - NP_001344102
swissprot - Q91VJ4
Ensembl - ENSMUSG00000024006
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stk38aENSDARG00000019973Danio rerio
 stk38bENSDARG00000018516Danio rerio
 STK38ENSGALG00000000523Gallus gallus
 STK38ENSG00000112079Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7TSE6 / Stk38l / Mus musculus serine/threonine kinase 38 like (Stk38l), transcript variant 2, mRNA. / Q9Y2H1* / serine/threonine kinase 38 like*ENSMUSG0000000163085
Lats2 / Q7TSJ6 / Serine/threonine-protein kinase LATS2 / Q9NRM7* / large tumor suppressor kinase 2*ENSMUSG0000002195943
Lats1 / Q8BYR2 / Serine/threonine-protein kinase LATS1 / O95835* / large tumor suppressor kinase 1*ENSMUSG0000004002142
Q3UU96 / Cdc42bpa / Serine/threonine-protein kinase MRCK alpha / Q5VT25* / CDC42 binding protein kinase alpha*ENSMUSG0000002649037
Q7TT50 / Cdc42bpb / CDC42 binding protein kinase beta / Q9Y5S2*ENSMUSG0000002127936
Q80UW5 / Cdc42bpg / Serine/threonine-protein kinase MRCK gamma / Q6DT37* / CDC42 binding protein kinase gamma*ENSMUSG0000002476935
Rock1 / P70335 / Rho-associated protein kinase 1 / Q13464* / Rho associated coiled-coil containing protein kinase 1*ENSMUSG0000002429034
Rock2 / Rho associated coiled-coil containing protein kinase 2 / O75116*ENSMUSG0000002058032
Dmpk / P54265 / Myotonin-protein kinase / Q09013* / DM1 protein kinase*ENSMUSG0000003040932
Cit / citron rho-interacting serine/threonine kinase / O14578*ENSMUSG0000002951630
Lats2 / Q9NRM7* / large tumor suppressor kinase 2*ENSMUSG0000011494229


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process ISO
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0043407 negative regulation of MAP kinase activity ISO
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding ISO
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sostdc1tm2Snd/Sostdc1tm2Snd
Genetic Background: involves: 129S/SvEv

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sostdc1tm2Snd/Sostdc1tm2Snd
Genetic Background: involves: 129S/SvEv

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Sostdc1tm2Snd/Sostdc1tm2Snd
Genetic Background: involves: 129S/SvEv

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Sostdc1tm2Snd/Sostdc1tm2Snd
Genetic Background: involves: 129S/SvEv

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Sostdc1tm2Snd/Sostdc1tm2Snd
Genetic Background: involves: 129S/SvEv

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Sostdc1tm2Snd/Sostdc1tm2Snd
Genetic Background: involves: 129S/SvEv

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sostdc1tm2Snd/Sostdc1tm2Snd
Genetic Background: involves: 129S/SvEv

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sostdc1tm2Snd/Sostdc1tm2Snd
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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