ENSMUSG00000029516


Mus musculus

Features
Gene ID: ENSMUSG00000029516
  
Biological name :Cit
  
Synonyms : Cit / citron rho-interacting serine/threonine kinase
  
Possible biological names infered from orthology : O14578
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 115845278
Gene end: 116008947
  
Corresponding Affymetrix probe sets: 10524790 (MoGene1.0st)   1426028_a_at (Mouse Genome 430 2.0 Array)   1427669_a_at (Mouse Genome 430 2.0 Array)   1455609_at (Mouse Genome 430 2.0 Array)   1458276_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107639
Ensembl peptide - ENSMUSP00000099620
Ensembl peptide - ENSMUSP00000115802
Ensembl peptide - ENSMUSP00000134875
Ensembl peptide - ENSMUSP00000122745
Ensembl peptide - ENSMUSP00000119769
Ensembl peptide - ENSMUSP00000062049
NCBI entrez gene - 12704     See in Manteia.
MGI - MGI:105313
RefSeq - XM_017320647
RefSeq - XM_011248163
RefSeq - XM_017320640
RefSeq - XM_017320641
RefSeq - XM_017320642
RefSeq - XM_017320643
RefSeq - XM_017320644
RefSeq - XM_017320645
RefSeq - XM_017320646
RefSeq - NM_007708
RefSeq - XM_006530130
RefSeq - XM_006530131
RefSeq - XM_006530132
RefSeq - XM_006530133
RefSeq - XM_006530134
RefSeq - XM_006530135
RefSeq - XM_006530136
RefSeq - XM_006530137
RefSeq - XM_006530138
RefSeq - XM_006530139
RefSeq - XM_006530140
RefSeq - XM_006530141
RefSeq - XM_006530142
RefSeq - XM_006530143
RefSeq - XM_006530145
RefSeq - XM_006530146
RefSeq - XM_006530147
RefSeq - XM_006530148
RefSeq - XM_006530149
RefSeq - XM_006530150
RefSeq - XM_006530151
RefSeq - XM_006530152
RefSeq Peptide - NP_031734
swissprot - D3Z477
swissprot - D3Z1U0
swissprot - F6SBR5
swissprot - E9QL53
swissprot - D3Z1K6
swissprot - D3YU89
swissprot - H3BJ74
Ensembl - ENSMUSG00000029516
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 citbENSDARG00000088825Danio rerio
 CITENSGALG00000007354Gallus gallus
 CITENSG00000122966Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3UU96 / Cdc42bpa / Serine/threonine-protein kinase MRCK alpha / Q5VT25* / CDC42 binding protein kinase alpha*ENSMUSG0000002649022
Q7TT50 / Cdc42bpb / CDC42 binding protein kinase beta / Q9Y5S2*ENSMUSG0000002127922
Q80UW5 / Cdc42bpg / Serine/threonine-protein kinase MRCK gamma / Q6DT37* / CDC42 binding protein kinase gamma*ENSMUSG0000002476920
Rock1 / P70335 / Rho-associated protein kinase 1 / Q13464* / Rho associated coiled-coil containing protein kinase 1*ENSMUSG0000002429017
Rock2 / Rho associated coiled-coil containing protein kinase 2 / O75116*ENSMUSG0000002058016
Dmpk / P54265 / Myotonin-protein kinase / Q09013* / DM1 protein kinase*ENSMUSG0000003040910
Lats1 / Q8BYR2 / Serine/threonine-protein kinase LATS1 / O95835* / large tumor suppressor kinase 1*ENSMUSG000000400218
Lats2 / Q7TSJ6 / Serine/threonine-protein kinase LATS2 / Q9NRM7* / large tumor suppressor kinase 2*ENSMUSG000000219598
Q7TSE6 / Stk38l / Mus musculus serine/threonine kinase 38 like (Stk38l), transcript variant 2, mRNA. / Q9Y2H1* / serine/threonine kinase 38 like*ENSMUSG000000016307
Stk38 / Q91VJ4 / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA. / Q15208* / serine/threonine kinase 38*ENSMUSG000000240067
Lats2 / Q9NRM7* / large tumor suppressor kinase 2*ENSMUSG000001149425


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001180  Citron homology (CNH) domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017405  Citron Rho-interacting kinase
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007030 Golgi organization IEA
 biological_processGO:0008064 regulation of actin polymerization or depolymerization IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032467 positive regulation of cytokinesis IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0031985 Golgi cisterna IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
RHO GTPases activate CIT


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0002685 abnormal proliferation of spermatogonia "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cisd2tm1a(EUCOMM)Wtsi/Cisd2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cisd2tm1a(EUCOMM)Wtsi/H

 MP:0006099 thin granule layer "reduced thickness of the innermost cortical layer of the cerebellum that contains granule cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0009964 abnormal cerebellum lobule morphology "any structural anomaly of the ten gyri of the cerebellar cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0012089 decreased midbrain size "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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