ENSG00000101109


Homo sapiens

Features
Gene ID: ENSG00000101109
  
Biological name :STK4
  
Synonyms : Q13043 / serine/threonine kinase 4 / STK4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.12
Gene start: 44966474
Gene end: 45079959
  
Corresponding Affymetrix probe sets: 1569791_at (Human Genome U133 Plus 2.0 Array)   205411_at (Human Genome U133 Plus 2.0 Array)   211085_s_at (Human Genome U133 Plus 2.0 Array)   223746_at (Human Genome U133 Plus 2.0 Array)   225364_at (Human Genome U133 Plus 2.0 Array)   236259_at (Human Genome U133 Plus 2.0 Array)   243981_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482076
Ensembl peptide - ENSP00000361892
Ensembl peptide - ENSP00000443514
Ensembl peptide - ENSP00000479564
Ensembl peptide - ENSP00000361887
NCBI entrez gene - 6789     See in Manteia.
OMIM - 604965
RefSeq - XM_017028033
RefSeq - XM_011529018
RefSeq - XM_011529020
RefSeq - XM_017028029
RefSeq - XM_017028030
RefSeq - XM_017028031
RefSeq - XM_017028032
RefSeq - NM_006282
RefSeq - XM_005260530
RefSeq - XM_005260531
RefSeq - XM_005260532
RefSeq - XM_005260533
RefSeq Peptide - NP_001339314
RefSeq Peptide - NP_006273
swissprot - A0A087WYT4
swissprot - F5H5B4
swissprot - A0A087WVN8
swissprot - Q13043
Ensembl - ENSG00000101109
  
Related genetic diseases (OMIM): 614868 - T-cell immunodeficiency, recurrent infections, autoimmunity, and cardiac malformations, 614868
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 STK4ENSGALG00000004098Gallus gallus
 Stk4ENSMUSG00000018209Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STK3 / Q13188 / serine/threonine kinase 3ENSG0000010437577
STK24 / Q9Y6E0 / serine/threonine kinase 24ENSG0000010257237
STK25 / O00506 / serine/threonine kinase 25ENSG0000011569436
STK26 / Q9P289 / serine/threonine kinase 26ENSG0000013460236


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011524  SARAH domain
 IPR017441  Protein kinase, ATP binding site
 IPR024205  Mst1 SARAH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IDA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IEA
 biological_processGO:0001841 neural tube formation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0003157 endocardium development IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0035329 hippo signaling IDA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0046621 negative regulation of organ growth IEA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0060215 primitive hemopoiesis IEA
 biological_processGO:0060706 cell differentiation involved in embryonic placenta development IEA
 biological_processGO:0060800 regulation of cell differentiation involved in embryonic placenta development IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0097284 hepatocyte apoptotic process IEA
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity IDA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0001631 Atrial septal defect "Atrial septal defect (ASD) is a congenital heart defect that enables blood flow between the left and right atria via the interatrial septum. The three common types of ASD are sinus venosus defects, ostium secundum defects, and ostium primum defects." [HPO:curators]
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 HP:0001875 Neutropenia 
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 HP:0001888 Lymphopenia 
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 HP:0002718 Recurrent bacterial infections 
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 HP:0002721 Immunodeficiency 
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 HP:0002841 Fungal infections, recurrent 
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 HP:0004429 Recurrent viral infections 
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 HP:0200043 verrucae "Benign growths on the skin or mucous membranes that cause cosmetic problems as well as pain and discomfort. Warts most often occur on the hands, feet, and genital areas." [HPO:SKOEHLER]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction
 ENSG00000151748 SAV1 / Q9H4B6 / salvador family WW domain containing protein 1  / complex
 ENSG00000173542 MOB1B / Q7L9L4 / MOB kinase activator 1B  / reaction
 ENSG00000114978 MOB1A / Q9H8S9 / MOB kinase activator 1A  / reaction
 ENSG00000101109 STK4 / Q13043 / serine/threonine kinase 4  / complex
 ENSG00000131023 LATS1 / O95835 / large tumor suppressor kinase 1  / reaction
 ENSG00000150457 LATS2 / Q9NRM7 / large tumor suppressor kinase 2  / reaction






 

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