ENSG00000113645


Homo sapiens

Features
Gene ID: ENSG00000113645
  
Biological name :WWC1
  
Synonyms : Q8IX03 / WW and C2 domain containing 1 / WWC1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q34
Gene start: 168291651
Gene end: 168472303
  
Corresponding Affymetrix probe sets: 1554511_at (Human Genome U133 Plus 2.0 Array)   213085_s_at (Human Genome U133 Plus 2.0 Array)   216074_x_at (Human Genome U133 Plus 2.0 Array)   229180_at (Human Genome U133 Plus 2.0 Array)   236725_at (Human Genome U133 Plus 2.0 Array)   237238_at (Human Genome U133 Plus 2.0 Array)   241950_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377473
Ensembl peptide - ENSP00000428084
Ensembl peptide - ENSP00000429339
Ensembl peptide - ENSP00000265293
Ensembl peptide - ENSP00000427772
NCBI entrez gene - 23286     See in Manteia.
OMIM - 610533
RefSeq - XM_017009278
RefSeq - XM_011534487
RefSeq - XM_011534488
RefSeq - XM_011534489
RefSeq - XM_011534490
RefSeq - XM_011534491
RefSeq - XM_017009276
RefSeq - XM_017009277
RefSeq - NM_001161661
RefSeq - NM_001161662
RefSeq - NM_015238
RefSeq - XM_005265850
RefSeq - XM_005265853
RefSeq - XM_011534485
RefSeq - XM_011534486
RefSeq Peptide - NP_056053
RefSeq Peptide - NP_001155133
RefSeq Peptide - NP_001155134
swissprot - H0YAU4
swissprot - Q8IX03
swissprot - H3BLZ3
swissprot - H0YBE8
Ensembl - ENSG00000113645
  
Related genetic diseases (OMIM): 615602 - [Memory, enhanced, QTL], 615602
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wwc1ENSDARG00000076041Danio rerio
 WWC1ENSGALG00000001826Gallus gallus
 Wwc1ENSMUSG00000018849Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WWC2 / Q6AWC2 / WW and C2 domain containing 2ENSG0000015171851
WWC3 / Q9ULE0 / WWC family member 3ENSG0000004764439


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001202  WW domain
 IPR035892  C2 domain superfamily
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007221 positive regulation of transcription of Notch receptor target TAS
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030010 establishment of cell polarity TAS
 biological_processGO:0032386 regulation of intracellular transport TAS
 biological_processGO:0035329 hippo signaling TAS
 biological_processGO:0035330 regulation of hippo signaling IMP
 biological_processGO:0035331 negative regulation of hippo signaling IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0046621 negative regulation of organ growth IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0032947 protein-containing complex scaffold activity IDA


Pathways (from Reactome)
Pathway description
Signaling by Hippo
NOTCH3 Intracellular Domain Regulates Transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131023 LATS1 / O95835 / large tumor suppressor kinase 1  / reaction / complex
 ENSG00000150457 LATS2 / Q9NRM7 / large tumor suppressor kinase 2  / reaction / complex






 

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