ENSMUSG00000018849


Mus musculus

Features
Gene ID: ENSMUSG00000018849
  
Biological name :Wwc1
  
Synonyms : Q5SXA9 / Wwc1 / WW, C2 and coiled-coil domain containing 1
  
Possible biological names infered from orthology : Q8IX03 / WW and C2 domain containing 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A4
Gene start: 35838400
Gene end: 35980527
  
Corresponding Affymetrix probe sets: 10385175 (MoGene1.0st)   1420007_at (Mouse Genome 430 2.0 Array)   1420008_s_at (Mouse Genome 430 2.0 Array)   1420009_at (Mouse Genome 430 2.0 Array)   1427261_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018993
NCBI entrez gene - 211652     See in Manteia.
MGI - MGI:2388637
RefSeq - NM_170779
RefSeq Peptide - NP_740749
swissprot - Q5SXA9
Ensembl - ENSMUSG00000018849
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wwc1ENSDARG00000076041Danio rerio
 WWC1ENSGALG00000001826Gallus gallus
 WWC1ENSG00000113645Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wwc2 / Q6NXJ0 / WW, C2 and coiled-coil domain containing 2 / Q6AWC2* / WW and C2 domain containing 2*ENSMUSG0000003156351


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001202  WW domain
 IPR035892  C2 domain superfamily
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0035330 regulation of hippo signaling IEA
 biological_processGO:0035331 negative regulation of hippo signaling IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0046621 negative regulation of organ growth IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032587 ruffle membrane ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak2m1Dlbr/Jak2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0012293 impaired active avoidance behavior "impaired ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment" [MGI:csmith]
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Allelic Composition: Jak2m1Dlbr/Jak2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Jak2m1Dlbr/Jak2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021959 Lats2 / Q7TSJ6 / Serine/threonine-protein kinase LATS2 / Q9NRM7* / large tumor suppressor kinase 2*  / reaction / complex
 ENSMUSG00000040021 Lats1 / Q8BYR2 / Serine/threonine-protein kinase LATS1 / O95835* / large tumor suppressor kinase 1*  / reaction / complex






 

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