ENSG00000133026


Homo sapiens

Features
Gene ID: ENSG00000133026
  
Biological name :MYH10
  
Synonyms : MYH10 / myosin heavy chain 10 / P35580
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p13.1
Gene start: 8474205
Gene end: 8630761
  
Corresponding Affymetrix probe sets: 212372_at (Human Genome U133 Plus 2.0 Array)   213067_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000408220
Ensembl peptide - ENSP00000269243
Ensembl peptide - ENSP00000353590
Ensembl peptide - ENSP00000369315
NCBI entrez gene - 4628     See in Manteia.
OMIM - 160776
RefSeq - XM_017024682
RefSeq - NM_001256012
RefSeq - NM_001256095
RefSeq - NM_005964
RefSeq - XM_017024677
RefSeq - XM_017024678
RefSeq - XM_017024679
RefSeq - XM_017024680
RefSeq - XM_017024681
RefSeq - XM_011523875
RefSeq - XM_011523878
RefSeq - XM_011523879
RefSeq - XM_011523880
RefSeq Peptide - NP_001242941
RefSeq Peptide - NP_001243024
RefSeq Peptide - NP_005955
swissprot - P35580
swissprot - E7ERA5
Ensembl - ENSG00000133026
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myh10ENSDARG00000000103Danio rerio
 MYH10ENSGALG00000001183Gallus gallus
 Myh10ENSMUSG00000020900Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MYH9 / P35579 / myosin heavy chain 9ENSG0000010034576
MYH11 / P35749 / myosin heavy chain 11ENSG0000013339275
MYH14 / Q7Z406 / myosin heavy chain 14ENSG0000010535766
MYH7B / A7E2Y1 / myosin heavy chain 7BENSG0000007881440
MYH3 / P11055 / myosin heavy chain 3ENSG0000010906340
MYH7 / P12883 / myosin heavy chain 7ENSG0000009205440
MYH13 / Q9UKX3 / myosin heavy chain 13ENSG0000000678839
MYH4 / Q9Y623 / myosin heavy chain 4ENSG0000026442439
MYH8 / P13535 / myosin heavy chain 8ENSG0000013302039
MYH2 / Q9UKX2 / myosin heavy chain 2ENSG0000012541439
MYH6 / P13533 / myosin heavy chain 6ENSG0000019761639
MYH1 / P12882 / myosin heavy chain 1ENSG0000010906139
MYH15 / Q9Y2K3 / myosin heavy chain 15ENSG0000014482136


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001609  Myosin head, motor domain
 IPR002928  Myosin tail
 IPR004009  Myosin, N-terminal, SH3-like
 IPR008989  Myosin S1 fragment, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IDA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001778 plasma membrane repair IEA
 biological_processGO:0003279 cardiac septum development IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006930 substrate-dependent cell migration, cell extension IEA
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007097 nuclear migration IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007512 adult heart development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0021592 fourth ventricle development IEA
 biological_processGO:0021670 lateral ventricle development IEA
 biological_processGO:0021678 third ventricle development IEA
 biological_processGO:0021680 cerebellar Purkinje cell layer development IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030048 actin filament-based movement IDA
 biological_processGO:0030239 myofibril assembly IEA
 biological_processGO:0031032 actomyosin structure organization IMP
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0035904 aorta development IEA
 biological_processGO:0050714 positive regulation of protein secretion IMP
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0055003 cardiac myofibril assembly IEA
 biological_processGO:0055015 ventricular cardiac muscle cell development IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0060976 coronary vasculature development IEA
 biological_processGO:0098885 modification of postsynaptic actin cytoskeleton IEA
 cellular_componentGO:0001725 stress fiber IDA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005844 polysome IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016459 myosin complex NAS
 cellular_componentGO:0016460 myosin II complex IDA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0032154 cleavage furrow IDA
 cellular_componentGO:0042641 actomyosin IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097513 myosin II filament IDA
 molecular_functionGO:0000146 microfilament motor activity IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016887 ATPase activity IMP
 molecular_functionGO:0030898 actin-dependent ATPase activity IDA
 molecular_functionGO:0035613 RNA stem-loop binding IDA
 molecular_functionGO:0043531 ADP binding IDA
 molecular_functionGO:0048027 mRNA 5"-UTR binding IDA
 molecular_functionGO:0051015 actin filament binding IDA


Pathways (from Reactome)
Pathway description
EPHA-mediated growth cone collapse
Sema4D induced cell migration and growth-cone collapse
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100345 MYH9 / P35579 / myosin heavy chain 9  / complex
 ENSG00000118680 MYL12B / O14950 / myosin light chain 12B  / complex
 ENSG00000058272 O14974 / PPP1R12A / protein phosphatase 1 regulatory subunit 12A  / reaction
 ENSG00000122966 CIT / O14578 / citron rho-interacting serine/threonine kinase  / reaction
 ENSG00000105357 MYH14 / Q7Z406 / myosin heavy chain 14  / complex
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000134318 ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2  / reaction
 ENSG00000077157 O60237 / PPP1R12B / protein phosphatase 1 regulatory subunit 12B  / reaction
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / reaction
 ENSG00000101335 MYL9 / P24844 / myosin light chain 9  / complex
 ENSG00000092841 MYL6 / P60660 / myosin light chain 6  / complex
 ENSG00000213639 P62140 / PPP1CB / protein phosphatase 1 catalytic subunit beta  / reaction
 ENSG00000133392 MYH11 / P35749 / myosin heavy chain 11  / complex
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / reaction
 ENSG00000133026 MYH10 / P35580 / myosin heavy chain 10  / complex
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / reaction
 ENSG00000065534 MYLK / Q15746 / myosin light chain kinase  / reaction
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / reaction
 ENSG00000067900 ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1  / reaction






 

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