ENSG00000092841


Homo sapiens

Features
Gene ID: ENSG00000092841
  
Biological name :MYL6
  
Synonyms : MYL6 / myosin light chain 6 / P60660
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.2
Gene start: 56158161
Gene end: 56163496
  
Corresponding Affymetrix probe sets: 212082_s_at (Human Genome U133 Plus 2.0 Array)   214002_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000448859
Ensembl peptide - ENSP00000450116
Ensembl peptide - ENSP00000449086
Ensembl peptide - ENSP00000293422
Ensembl peptide - ENSP00000301540
Ensembl peptide - ENSP00000441750
Ensembl peptide - ENSP00000446640
Ensembl peptide - ENSP00000446687
Ensembl peptide - ENSP00000446709
Ensembl peptide - ENSP00000446714
Ensembl peptide - ENSP00000446721
Ensembl peptide - ENSP00000446955
Ensembl peptide - ENSP00000448101
Ensembl peptide - ENSP00000448457
NCBI entrez gene - 4637     See in Manteia.
OMIM - 609931
RefSeq - NM_021019
RefSeq - NM_079423
RefSeq Peptide - NP_066299
RefSeq Peptide - NP_524147
swissprot - F8W1R7
swissprot - G3V1V0
swissprot - G3V1Y7
swissprot - G8JLA2
swissprot - H0YI43
swissprot - J3KND3
swissprot - B7Z6Z4
swissprot - P60660
swissprot - F8VPF3
swissprot - F8VXL3
swissprot - F8VZU9
swissprot - F8W180
Ensembl - ENSG00000092841
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myl6ENSDARG00000008494Danio rerio
 zgc:153867ENSDARG00000033738Danio rerio
 MYL6ENSGALG00000035086Gallus gallus
 Myl6ENSMUSG00000090841Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MYL6B / P14649 / myosin light chain 6BENSG0000019646580
MYL4 / P12829 / myosin light chain 4ENSG0000019833677
MYL1 / P05976 / myosin light chain 1ENSG0000016853073
MYL3 / P08590 / myosin light chain 3ENSG0000016080873


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction TAS
 biological_processGO:0007519 skeletal muscle tissue development TAS
 biological_processGO:0030049 muscle filament sliding TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016459 myosin complex TAS
 cellular_componentGO:0016461 unconventional myosin complex TAS
 cellular_componentGO:0031982 vesicle HDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003774 motor activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008307 structural constituent of muscle IDA
 molecular_functionGO:0030898 actin-dependent ATPase activity ISS


Pathways (from Reactome)
Pathway description
EPHA-mediated growth cone collapse
Sema4D induced cell migration and growth-cone collapse
Smooth Muscle Contraction
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000118680 MYL12B / O14950 / myosin light chain 12B  / complex
 ENSG00000058272 O14974 / PPP1R12A / protein phosphatase 1 regulatory subunit 12A  / reaction
 ENSG00000122966 CIT / O14578 / citron rho-interacting serine/threonine kinase  / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000134318 ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2  / reaction
 ENSG00000077157 O60237 / PPP1R12B / protein phosphatase 1 regulatory subunit 12B  / reaction
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / reaction
 ENSG00000101335 MYL9 / P24844 / myosin light chain 9  / complex
 ENSG00000105357 MYH14 / Q7Z406 / myosin heavy chain 14  / complex
 ENSG00000092841 MYL6 / P60660 / myosin light chain 6  / complex
 ENSG00000133026 MYH10 / P35580 / myosin heavy chain 10  / complex
 ENSG00000133392 MYH11 / P35749 / myosin heavy chain 11  / complex
 ENSG00000100345 MYH9 / P35579 / myosin heavy chain 9  / complex
 ENSG00000213639 P62140 / PPP1CB / protein phosphatase 1 catalytic subunit beta  / reaction
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / reaction
 ENSG00000065534 MYLK / Q15746 / myosin light chain kinase  / reaction
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / reaction
 ENSG00000067900 ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1  / reaction






 

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contact: otassy@igbmc.fr