Manteia

ENSG00000143878

Homo sapiens

Features

Gene ID:	ENSG00000143878

Biological name :	RHOB

Synonyms :	P62745 / ras homolog family member B / RHOB

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	2
Strand:	1
Band:	p24.1
Gene start:	20447074
Gene end:	20449445

Corresponding Affymetrix probe sets:	1553962_s_at (Human Genome U133 Plus 2.0 Array) 1553963_at (Human Genome U133 Plus 2.0 Array) 1553965_x_at (Human Genome U133 Plus 2.0 Array) 212099_at (Human Genome U133 Plus 2.0 Array) 226417_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000272233 NCBI entrez gene - 388 See in Manteia. OMIM - 165370 RefSeq - NM_004040 RefSeq Peptide - NP_004031 swissprot - P62745 Ensembl - ENSG00000143878

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
RHOB	ENSGALG00000016485	Gallus gallus
Rhob	ENSMUSG00000054364	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
RHOA / P61586 / ras homolog family member A	ENSG00000067560	84
RHOC / P08134 / ras homolog family member C	ENSG00000155366	83
AL603832.3	ENSG00000271810	52
RHOD / O00212 / ras homolog family member D	ENSG00000173156	49
RND3 / P61587 / Rho family GTPase 3	ENSG00000115963	47
RHOF / Q9HBH0 / ras homolog family member F, filopodia associated	ENSG00000139725	46
RND2 / P52198 / Rho family GTPase 2	ENSG00000108830	43
RND1 / Q92730 / Rho family GTPase 1	ENSG00000172602	40

Protein motifs (from Interpro)

Interpro ID	Name
IPR001806	Small GTPase superfamily
IPR003578	Small GTPase superfamily, Rho type
IPR005225	Small GTP-binding protein domain
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000281	mitotic cytokinesis	IMP
biological_process	GO:0001525	angiogenesis	IEA
biological_process	GO:0006886	intracellular protein transport	IEA
biological_process	GO:0006915	apoptotic process	TAS
biological_process	GO:0007155	cell adhesion	ISS
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	TAS
biological_process	GO:0007264	small GTPase mediated signal transduction	IEA
biological_process	GO:0007266	Rho protein signal transduction	TAS
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0008333	endosome to lysosome transport	IDA
biological_process	GO:0010595	positive regulation of endothelial cell migration	IMP
biological_process	GO:0015031	protein transport	IEA
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030168	platelet activation	TAS
biological_process	GO:0030334	regulation of cell migration	IGI
biological_process	GO:0030336	negative regulation of cell migration	IDA
biological_process	GO:0043065	positive regulation of apoptotic process	IEA
biological_process	GO:0045766	positive regulation of angiogenesis	IEA
biological_process	GO:0045786	negative regulation of cell cycle	IEA
biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	TAS
biological_process	GO:0061154	endothelial tube morphogenesis	IMP
biological_process	GO:0070301	cellular response to hydrogen peroxide	IDA
biological_process	GO:0071479	cellular response to ionizing radiation	IDA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005634	nucleus	ISS
cellular_component	GO:0005768	endosome	IEA
cellular_component	GO:0005769	early endosome	IEA
cellular_component	GO:0005770	late endosome	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005925	focal adhesion	HDA
cellular_component	GO:0010008	endosome membrane	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0031902	late endosome membrane	IEA
cellular_component	GO:0032154	cleavage furrow	IEA
cellular_component	GO:0070062	extracellular exosome	HDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003924	GTPase activity	TAS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005525	GTP binding	TAS
molecular_function	GO:0019003	GDP binding	IEA

Pathways (from Reactome)

Pathway description

GPVI-mediated activation cascade

Rho GTPase cycle

G alpha (12/13) signalling events

Sema4D induced cell migration and growth-cone collapse

RHO GTPases activate PKNs

RHO GTPases activate CIT

RHO GTPases Activate ROCKs

RHO GTPases Activate Formins

RHO GTPases Activate Rhotekin and Rhophilins

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000114993	RTKN / Q9BST9 / rhotekin	/ complex / reaction
ENSG00000131504	DIAPH1 / O60610 / diaphanous related formin 1	/ reaction / complex
ENSG00000122966	CIT / O14578 / citron rho-interacting serine/threonine kinase	/ complex / reaction
ENSG00000164050	O43157 / PLXNB1 / plexin B1	/ reaction
ENSG00000139734	DIAPH3 / Q9NSV4 / diaphanous related formin 3	/ complex / reaction
ENSG00000132535	DLG4 / P78352 / discs large MAGUK scaffold protein 4	/ complex / reaction
ENSG00000118193	KIF14 / Q15058 / kinesin family member 14	/ reaction / complex
ENSG00000092841	MYL6 / P60660 / myosin light chain 6	/ reaction
ENSG00000106683	LIMK1 / P53667 / LIM domain kinase 1	/ reaction
ENSG00000065243	PKN2 / Q16513 / protein kinase N2	/ reaction / complex
ENSG00000131941	RHPN2 / Q8IUC4 / rhophilin Rho GTPase binding protein 2	/ reaction / complex
ENSG00000133026	MYH10 / P35580 / myosin heavy chain 10	/ reaction
ENSG00000123143	PKN1 / Q16512 / protein kinase N1	/ reaction / complex
ENSG00000101335	MYL9 / P24844 / myosin light chain 9	/ reaction
ENSG00000140992	PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1	/ reaction / complex
ENSG00000058272	O14974 / PPP1R12A / protein phosphatase 1 regulatory subunit 12A	/ reaction
ENSG00000067900	ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1	/ complex / reaction
ENSG00000134318	ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2	/ complex / reaction
ENSG00000213639	P62140 / PPP1CB / protein phosphatase 1 catalytic subunit beta	/ reaction
ENSG00000105357	MYH14 / Q7Z406 / myosin heavy chain 14	/ reaction
ENSG00000118680	MYL12B / O14950 / myosin light chain 12B	/ reaction
ENSG00000100345	MYH9 / P35579 / myosin heavy chain 9	/ reaction
ENSG00000133392	MYH11 / P35749 / myosin heavy chain 11	/ reaction
ENSG00000077157	O60237 / PPP1R12B / protein phosphatase 1 regulatory subunit 12B	/ reaction
ENSG00000141736	ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2	/ reaction
ENSG00000172602	RND1 / Q92730 / Rho family GTPase 1	/ reaction
ENSG00000187764	Q92854 / SEMA4D / semaphorin 4D	/ reaction
ENSG00000132694	O15085 / ARHGEF11 / Rho guanine nucleotide exchange factor 11	/ reaction
ENSG00000196914	Q9NZN5 / ARHGEF12 / Rho guanine nucleotide exchange factor 12	/ reaction
ENSG00000198901	PRC1 / O43663 / protein regulator of cytokinesis 1	/ reaction / complex
ENSG00000160293	VAV2 / P52735 / vav guanine nucleotide exchange factor 2	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr