ENSG00000114993


Homo sapiens

Features
Gene ID: ENSG00000114993
  
Biological name :RTKN
  
Synonyms : Q9BST9 / rhotekin / RTKN
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p13.1
Gene start: 74425836
Gene end: 74442422
  
Corresponding Affymetrix probe sets: 225150_s_at (Human Genome U133 Plus 2.0 Array)   225151_at (Human Genome U133 Plus 2.0 Array)   239653_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000491825
Ensembl peptide - ENSP00000233330
Ensembl peptide - ENSP00000272430
Ensembl peptide - ENSP00000305298
NCBI entrez gene - 6242     See in Manteia.
OMIM - 602288
RefSeq - XM_017004640
RefSeq - NM_001015055
RefSeq - NM_001015056
RefSeq - NM_033046
RefSeq - XM_017004635
RefSeq - XM_017004636
RefSeq - XM_017004637
RefSeq - XM_017004638
RefSeq - XM_017004639
RefSeq - XM_005264478
RefSeq - XM_005264479
RefSeq Peptide - NP_001015055
RefSeq Peptide - NP_001015056
RefSeq Peptide - NP_149035
swissprot - Q9BST9
swissprot - A0A1W2PPZ2
Ensembl - ENSG00000114993
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rtkn2bENSDARG00000052903Danio rerio
 si:dkey-40c11.1ENSDARG00000031345Danio rerio
 RtknENSMUSG00000034930Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RTKN2 / Q8IZC4 / rhotekin 2ENSG0000018201037


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011072  HR1 rho-binding domain
 IPR011993  PH-like domain superfamily
 IPR012966  Anillin homology domain
 IPR030471  Rhotekin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007266 Rho protein signal transduction IDA
 biological_processGO:0032185 septin cytoskeleton organization IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0042981 regulation of apoptotic process IDA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005095 GTPase inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0017049 GTP-Rho binding IDA


Pathways (from Reactome)
Pathway description
RHO GTPases Activate Rhotekin and Rhophilins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000213977 O14907 / TAX1BP3 / Tax1 binding protein 3  / complex / reaction
 ENSG00000104863 LIN7B / Q9HAP6 / lin-7 homolog B, crumbs cell polarity complex component  / reaction / complex
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction / complex
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / complex / reaction
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / complex / reaction






 

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