ENSG00000065243


Homo sapiens

Features
Gene ID: ENSG00000065243
  
Biological name :PKN2
  
Synonyms : PKN2 / protein kinase N2 / Q16513
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p22.2
Gene start: 88684222
Gene end: 88836255
  
Corresponding Affymetrix probe sets: 210969_at (Human Genome U133 Plus 2.0 Array)   212628_at (Human Genome U133 Plus 2.0 Array)   212629_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000317851
Ensembl peptide - ENSP00000359552
Ensembl peptide - ENSP00000389076
Ensembl peptide - ENSP00000401125
Ensembl peptide - ENSP00000359544
NCBI entrez gene - 5586     See in Manteia.
OMIM - 602549
RefSeq - XM_017001783
RefSeq - NM_001320707
RefSeq - NM_001320708
RefSeq - NM_001320709
RefSeq - NM_006256
RefSeq - XM_011541772
RefSeq - XM_017001782
RefSeq Peptide - NP_001307636
RefSeq Peptide - NP_001307637
RefSeq Peptide - NP_001307638
RefSeq Peptide - NP_006247
swissprot - Q16513
swissprot - B1AL79
swissprot - H0Y429
swissprot - H0Y5V5
Ensembl - ENSG00000065243
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pkn2ENSDARG00000101983Danio rerio
 zgc:153916ENSDARG00000101293Danio rerio
 PKN2ENSGALG00000006237Gallus gallus
 Pkn2ENSMUSG00000004591Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PKN1 / Q16512 / protein kinase N1ENSG0000012314359
PKN3 / Q6P5Z2 / protein kinase N3ENSG0000016044747
AL355916.3ENSG000002589897


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011072  HR1 rho-binding domain
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR035892  C2 domain superfamily
 IPR036274  HR1 repeat superfamily
 IPR037313  Serine/threonine-protein kinase N, first HR1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0010631 epithelial cell migration IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0032467 positive regulation of cytokinesis IMP
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043297 apical junction assembly IEA
 biological_processGO:0045070 positive regulation of viral genome replication IMP
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:2000145 regulation of cell motility IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043296 apical junction complex IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017049 GTP-Rho binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IDA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0070063 RNA polymerase binding IPI


Pathways (from Reactome)
Pathway description
RHO GTPases activate PKNs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction / complex
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / reaction / complex
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / reaction / complex
 ENSG00000140992 PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1  / complex / reaction






 

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