ENSG00000058272


Homo sapiens

Features
Gene ID: ENSG00000058272
  
Biological name :PPP1R12A
  
Synonyms : O14974 / PPP1R12A / protein phosphatase 1 regulatory subunit 12A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q21.31
Gene start: 79773563
Gene end: 79935460
  
Corresponding Affymetrix probe sets: 201602_s_at (Human Genome U133 Plus 2.0 Array)   201603_at (Human Genome U133 Plus 2.0 Array)   201604_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450061
Ensembl peptide - ENSP00000450059
Ensembl peptide - ENSP00000489242
Ensembl peptide - ENSP00000261207
Ensembl peptide - ENSP00000389168
Ensembl peptide - ENSP00000416769
Ensembl peptide - ENSP00000446816
Ensembl peptide - ENSP00000446855
Ensembl peptide - ENSP00000447144
Ensembl peptide - ENSP00000447338
Ensembl peptide - ENSP00000449514
Ensembl peptide - ENSP00000449647
Ensembl peptide - ENSP00000449666
Ensembl peptide - ENSP00000449843
NCBI entrez gene - 4659     See in Manteia.
OMIM - 602021
RefSeq - XM_017019330
RefSeq - XM_011538376
RefSeq - XM_011538377
RefSeq - XM_011538378
RefSeq - XM_011538379
RefSeq - XM_011538380
RefSeq - XM_011538383
RefSeq - XM_011538384
RefSeq - XM_011538385
RefSeq - XM_017019323
RefSeq - XM_017019324
RefSeq - XM_017019325
RefSeq - XM_017019326
RefSeq - XM_017019327
RefSeq - XM_017019328
RefSeq - XM_017019329
RefSeq - NM_001143885
RefSeq - NM_001143886
RefSeq - NM_001244990
RefSeq - NM_001244992
RefSeq - NM_002480
RefSeq - XM_005268887
RefSeq - XM_011538374
RefSeq - XM_011538375
RefSeq Peptide - NP_002471
RefSeq Peptide - NP_001231919
RefSeq Peptide - NP_001231921
RefSeq Peptide - NP_001137357
RefSeq Peptide - NP_001137358
swissprot - H0YIM2
swissprot - H0YIS3
swissprot - F8VW28
swissprot - O14974
swissprot - A0A0U1RQZ1
swissprot - H0YIS4
swissprot - F8VZN8
swissprot - H0YHI8
swissprot - H0YHL8
swissprot - H0YIL7
Ensembl - ENSG00000058272
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1r12aENSDARG00000010784Danio rerio
 Q90623ENSGALG00000010325Gallus gallus
 Q9DBR7ENSMUSG00000019907Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O60237 / PPP1R12B / protein phosphatase 1 regulatory subunit 12BENSG0000007715750
Q9BZL4 / PPP1R12C / protein phosphatase 1 regulatory subunit 12CENSG0000012550334
Q96I34 / PPP1R16A / protein phosphatase 1 regulatory subunit 16AENSG0000016097216
Q96T49 / PPP1R16B / protein phosphatase 1 regulatory subunit 16BENSG0000010144515
Q96KQ4 / PPP1R13B / protein phosphatase 1 regulatory subunit 13BENSG0000008880813
Q13625 / TP53BP2 / tumor protein p53 binding protein 2ENSG0000014351413
Q8WUF5 / PPP1R13L / protein phosphatase 1 regulatory subunit 13 likeENSG000001048817
Q86WC6 / PPP1R27 / protein phosphatase 1 regulatory subunit 27ENSG000001826765
NRARP / Q7Z6K4 / NOTCH regulated ankyrin repeat proteinENSG000001984353


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR017401  Protein phosphatase 1 regulatory subunit 12A/B/C
 IPR020683  Ankyrin repeat-containing domain
 IPR031775  cGMP-dependent protein kinase, interacting domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0006470 protein dephosphorylation IMP
 biological_processGO:0007098 centrosome cycle IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030155 regulation of cell adhesion IDA
 biological_processGO:0035507 regulation of myosin-light-chain-phosphatase activity IDA
 biological_processGO:0035508 positive regulation of myosin-light-chain-phosphatase activity IMP
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0043086 negative regulation of catalytic activity IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046822 regulation of nucleocytoplasmic transport IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 cellular_componentGO:0000776 kinetochore IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0030018 Z disc ISS
 cellular_componentGO:0031672 A band ISS
 cellular_componentGO:0043292 contractile fiber IDA
 cellular_componentGO:0072357 PTW/PP1 phosphatase complex IDA
 molecular_functionGO:0004857 enzyme inhibitor activity IDA
 molecular_functionGO:0004871 obsolete signal transducer activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019208 phosphatase regulator activity IMP
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0071889 14-3-3 protein binding IDA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000166851 PLK1 / P53350 / polo like kinase 1  / reaction
 ENSG00000101335 MYL9 / P24844 / myosin light chain 9  / reaction
 ENSG00000213639 P62140 / PPP1CB / protein phosphatase 1 catalytic subunit beta  / complex
 ENSG00000118680 MYL12B / O14950 / myosin light chain 12B  / reaction
 ENSG00000133392 MYH11 / P35749 / myosin heavy chain 11  / reaction
 ENSG00000133026 MYH10 / P35580 / myosin heavy chain 10  / reaction
 ENSG00000100345 MYH9 / P35579 / myosin heavy chain 9  / reaction
 ENSG00000077157 O60237 / PPP1R12B / protein phosphatase 1 regulatory subunit 12B  / complex
 ENSG00000105357 MYH14 / Q7Z406 / myosin heavy chain 14  / reaction
 ENSG00000092841 MYL6 / P60660 / myosin light chain 6  / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000134318 ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2  / reaction
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / reaction
 ENSG00000167641 Q96A00 / PPP1R14A / protein phosphatase 1 regulatory inhibitor subunit 14A  / reaction / complex
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / reaction
 ENSG00000067900 ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1  / reaction






 

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