ENSDARG00000010784


Danio rerio

Features
Gene ID: ENSDARG00000010784
  
Biological name :ppp1r12a
  
Synonyms : ppp1r12a / protein phosphatase 1, regulatory subunit 12A
  
Possible biological names infered from orthology : O14974 / protein phosphatase 1, regulatory (inhibitor) subunit 12A / Q9DBR7
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 21488990
Gene end: 21584158
  
Corresponding Affymetrix probe sets: Dr.11256.1.A1_at (Zebrafish Array)   Dr.15181.1.S1_at (Zebrafish Array)   NM_001003870_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000118021
NCBI entrez gene - 445393     See in Manteia.
RefSeq - NM_001003870
RefSeq Peptide - NP_001003870
swissprot - Z4YIS0
ZFIN ID - ZDB-GENE-041011-3
Ensembl - ENSDARG00000010784
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q90623ENSGALG00000010325Gallus gallus
 O14974ENSG00000058272Homo sapiens
 Q9DBR7ENSMUSG00000019907Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ppp1r12c / protein phosphatase 1, regulatory subunit 12C / Q9BZL4*ENSDARG0000005242327
ppp1r16a / protein phosphatase 1, regulatory subunit 16A / Q923M0* / Q96I34* / protein phosphatase 1, regulatory (inhibitor) subunit 16A*ENSDARG0000007698014
ppp1r13bb / protein phosphatase 1, regulatory subunit 13Bb / Q96KQ4* / Q62415* / PPP1R13B* / protein phosphatase 1 regulatory subunit 13B* / protein phosphatase 1, regulatory (inhibitor) subunit 13B*ENSDARG0000000914211
ppp1r13ba / protein phosphatase 1, regulatory subunit 13Ba / Q96KQ4* / Q62415* / PPP1R13B* / protein phosphatase 1 regulatory subunit 13B* / protein phosphatase 1, regulatory (inhibitor) subunit 13B*ENSDARG0000000437711
ppp1r16b / protein phosphatase 1, regulatory subunit 16B / Q8VHQ3* / Q96T49* / protein phosphatase 1, regulatory (inhibitor) subunit 16B*ENSDARG0000007986011
tp53bp2a / tumor protein p53 binding protein, 2a / Q13625* / TP53BP2* / Trp53bp2* / tumor protein p53 binding protein 2* / transformation related protein 53 binding protein 2*ENSDARG0000000913610
tp53bp2b / tumor protein p53 binding protein, 2b / Q13625* / TP53BP2* / Trp53bp2* / tumor protein p53 binding protein 2* / transformation related protein 53 binding protein 2*ENSDARG0000005485810
BX323087.1 / O60237* / PPP1R12B* / protein phosphatase 1 regulatory subunit 12B*ENSDARG000001171557
CABZ01068600.1ENSDARG000001134547
ppp1r13l / protein phosphatase 1, regulatory subunit 13 like / Q5I1X5* / Q8WUF5* / protein phosphatase 1, regulatory (inhibitor) subunit 13 like*ENSDARG000000137776
CU693479.1 / Q86WC6* / PPP1R27* / protein phosphatase 1 regulatory subunit 27*ENSDARG000001168065
ppp1r27b / protein phosphatase 1, regulatory subunit 27b / Q9D119* / Q86WC6* / PPP1R27* / protein phosphatase 1 regulatory subunit 27*ENSDARG000001005044
Q7T3Y0 / nrarpa / NOTCH regulated ankyrin repeat protein a / NRARP* / Q7Z6K4* / Q91ZA8* / NOTCH regulated ankyrin repeat protein* / Notch-regulated ankyrin repeat-containing protein *ENSDARG000000914193
nrarpb / Q7T3X9 / NOTCH regulated ankyrin repeat protein bENSDARG000000189583


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR031775  cGMP-dependent protein kinase, interacting domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 molecular_functionGO:0019208 phosphatase regulator activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000004 anterior axial hypoblast anterior axial hypoblast lamellipodium decreased amount , abnormal
anterior axial hypoblast filopodium decreased amount , abnormal
anterior axial hypoblast bleb increased amount , abnormal
Show

 ZFA:0000008 brain brain surface feature shape , abnormal
brain necrotic , abnormal
Show

 ZFA:0000029 hindbrain hindbrain axon mislocalised , abnormal
hindbrain glial cell (sensu Vertebrata) mislocalised , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary basal side increased angle to brain epithelium, abnormal
midbrain hindbrain boundary cell decreased length , abnormal
midbrain hindbrain boundary cell increased width , abnormal
midbrain hindbrain boundary cell increased area , abnormal
midbrain hindbrain boundary cell length , ameliorated
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000059 postoptic commissure postoptic commissure morphology , abnormal
postoptic commissure defasciculated , abnormal
postoptic commissure commissural neuron axon guidance disrupted , abnormal
postoptic commissure astrocyte mislocalised , abnormal
Show

 ZFA:0000075 spinal cord spinal cord has fewer parts of type ventricular zone radial glial cell, abnormal
spinal cord glial cell (sensu Vertebrata) mislocalised , abnormal
spinal cord neuron mislocalised , abnormal
Show

 ZFA:0000084 yolk yolk edematous , abnormal
Show

 ZFA:0000109 forebrain forebrain commissural neuron axon guidance disrupted , abnormal
Show

 ZFA:0000112 gut gut endodermal cell disorganized , abnormal
Show

 ZFA:0000114 heart heart increased accumulation blood , abnormal
heart quality , abnormal
Show

 ZFA:0000121 lateral plate mesoderm lateral plate mesoderm actin filament bundle increased size , abnormal
lateral plate mesoderm mesodermal cell disorganized , abnormal
lateral plate mesoderm apoptotic , abnormal
lateral plate mesoderm morphology , abnormal
Show

 ZFA:0000123 liver liver aplastic , abnormal
liver hepatocyte apoptotic , abnormal
liver decreased size , abnormal
liver mislocalised ventrally , abnormal
Show

 ZFA:0000124 liver primordium liver primordium decreased size , abnormal
liver primordium mislocalised posteriorly , abnormal
Show

 ZFA:0000135 notochord notochord undulate , abnormal
Show

 ZFA:0000155 somite somite quality , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II absent , abnormal
cranial nerve II decreased size , abnormal
cranial nerve II defasciculated , abnormal
cranial nerve II commissural neuron axon guidance disrupted , abnormal
Show

 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism necrotic , abnormal
whole organism anterior-posterior axis shortened , abnormal
Show

 ZFA:0001108 anterior commissure anterior commissure morphology , abnormal
anterior commissure defasciculated , abnormal
anterior commissure commissural neuron axon guidance disrupted , abnormal
anterior commissure astrocyte mislocalised , abnormal
Show

 ZFA:0001114 head head flat , abnormal
head edematous , abnormal
head decreased size , abnormal
head surface feature shape , abnormal
Show

 ZFA:0001115 trunk trunk necrotic , abnormal
trunk undulate , abnormal
trunk has fewer parts of type motor neuron axon, abnormal
trunk has fewer parts of type nerve glial cell (sensu Vertebrata), abnormal
trunk nerve truncated , abnormal
Show

 ZFA:0001117 post-vent region post-vent region quality , abnormal
Show

 ZFA:0001249 exocrine pancreas exocrine pancreas decreased size , abnormal
exocrine pancreas aplastic , abnormal
Show

 ZFA:0001261 ventricular system ventricular system structure, cavities , abnormal
Show

 ZFA:0009052 motor neuron motor neuron bleb assembly occurrence , ameliorated
motor neuron bleb assembly increased occurrence , abnormal
motor neuron membrane decreased amount , abnormal
motor neuron axon guidance process quality , abnormal
Show

 ZFA:0009063 peripheral neuron peripheral neuron quality , abnormal
Show

 ZFA:0009111 hepatocyte hepatocyte decreased amount , abnormal
Show

 ZFA:0009139 endodermal cell endodermal cell actin filament bundle increased size , abnormal
Show

 ZFA:0009243 CaP motoneuron CaP motoneuron axonogenesis process quality , abnormal
CaP motoneuron axon morphology , abnormal
CaP motoneuron axon increased branchiness , abnormal
CaP motoneuron cell body position , ameliorated
CaP motoneuron cell body mislocalised anteriorly , abnormal
Show

 ZFA:0009292 radial glial cell radial glial cell cell projection disorganized , abnormal
Show

 ZFA:0009306 neuroepithelial cell neuroepithelial cell actin filament decreased accumulation midbrain hindbrain boundary basal region, abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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