ENSMUSG00000019907


Mus musculus

Features
Gene ID: ENSMUSG00000019907
  
Biological name :Ppp1r12a
  
Synonyms : Ppp1r12a / protein phosphatase 1, regulatory (inhibitor) subunit 12A / Q9DBR7
  
Possible biological names infered from orthology : O14974 / protein phosphatase 1 regulatory subunit 12A
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D1
Gene start: 108162193
Gene end: 108284475
  
Corresponding Affymetrix probe sets: 10366238 (MoGene1.0st)   1429487_at (Mouse Genome 430 2.0 Array)   1437734_at (Mouse Genome 430 2.0 Array)   1437735_at (Mouse Genome 430 2.0 Array)   1453163_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069257
Ensembl peptide - ENSMUSP00000151478
Ensembl peptide - ENSMUSP00000151842
NCBI entrez gene - 17931     See in Manteia.
MGI - MGI:1309528
RefSeq - XM_006513329
RefSeq - NM_027892
RefSeq - XM_006513326
RefSeq - XM_006513327
RefSeq - XM_006513328
RefSeq Peptide - NP_082168
swissprot - Q9DBR7
swissprot - A0A1W2P750
Ensembl - ENSMUSG00000019907
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1r12aENSDARG00000010784Danio rerio
 Q90623ENSGALG00000010325Gallus gallus
 O14974ENSG00000058272Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BG95 / Ppp1r12b / protein phosphatase 1, regulatory (inhibitor) subunit 12B / O60237* / protein phosphatase 1 regulatory subunit 12B*ENSMUSG0000007355746
Q3UMT1 / Ppp1r12c / Protein phosphatase 1 regulatory subunit 12C / Q9BZL4*ENSMUSG0000001925430
Q923M0 / Ppp1r16a / protein phosphatase 1, regulatory (inhibitor) subunit 16A / Q96I34* / protein phosphatase 1 regulatory subunit 16A*ENSMUSG0000003381916
Q8VHQ3 / Ppp1r16b / protein phosphatase 1, regulatory (inhibitor) subunit 16B / Q96T49* / protein phosphatase 1 regulatory subunit 16B*ENSMUSG0000003775415
Trp53bp2 / transformation related protein 53 binding protein 2 / Q13625* / TP53BP2* / tumor protein p53 binding protein 2*ENSMUSG0000002651012
Q62415 / Ppp1r13b / protein phosphatase 1, regulatory (inhibitor) subunit 13B / Q96KQ4* / protein phosphatase 1 regulatory subunit 13B*ENSMUSG0000002128511
Q5I1X5 / Ppp1r13l / protein phosphatase 1, regulatory (inhibitor) subunit 13 like / Q8WUF5* / protein phosphatase 1 regulatory subunit 13 like*ENSMUSG000000407346
Q9D119 / Ppp1r27 / Protein phosphatase 1 regulatory subunit 27 / Q86WC6*ENSMUSG000000251295
Nrarp / Q91ZA8 / Notch-regulated ankyrin repeat-containing protein / Q7Z6K4* / NOTCH regulated ankyrin repeat protein*ENSMUSG000000782023


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR017401  Protein phosphatase 1 regulatory subunit 12A/B/C
 IPR020683  Ankyrin repeat-containing domain
 IPR031775  cGMP-dependent protein kinase, interacting domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0035507 regulation of myosin-light-chain-phosphatase activity IEA
 biological_processGO:0035508 positive regulation of myosin-light-chain-phosphatase activity IEA
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046822 regulation of nucleocytoplasmic transport IMP
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0031672 A band IDA
 cellular_componentGO:0043292 contractile fiber IEA
 cellular_componentGO:0072357 PTW/PP1 phosphatase complex IEA
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019208 phosphatase regulator activity ISS
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
RHO GTPases activate PKNs
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: GnaqM1J/Gnaq+
Genetic Background: C57BL/6J-GnaqM1J/GrsrJ

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0000767 abnormal smooth muscle morphology "anomalous structure of any of the unstriated muscle fibers of the internal organs, blood vessels, hair follicles, etc. " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0002581 abnormal ileum morphology "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0003290 hypoperistalsis "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0003622 incomplete emptying of bladder "upon urination, some urine is retained in the bladder instead of being excreted" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0003883 enlarged stomach "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0004002 abnormal jejunum morphology "malformation of the portion of the small intestine that extends from the duodenum to the ileum" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0004145 abnormal muscle electrophysiology "anomaly in the function of the musculature as it relates to electrical phenomena" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0009483 enlarged ileum "increased size of the portion of the small intestine that extends from the jejunum to the colon" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0009536 abnormal interstitial cell of Cajal morphology "any structural abnormality in the type of cell found in the gastrointestinal tract and serving as a pacemaker that triggers gut contraction; ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumours (GISTs) arise; abnormalities in the ICC network can cause chronic intestinal pseudo-obstruction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:16460275]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0011874 enlarged urinary bladder "increased size of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [MGI:Colin_McKerlie]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0011882 enlarged duodenum "increased size of the portion of the small intestine that extends from the pyloris to the junction with the jejunum" [MGI:Colin_McKerlie]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014956 P62141 / Ppp1cb / Serine/threonine-protein phosphatase PP1-beta catalytic subunit / P62140* / protein phosphatase 1 catalytic subunit beta*  / complex
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction
 ENSMUSG00000037166 Q91VC7 / Ppp1r14a / Protein phosphatase 1 regulatory subunit 14A / Q96A00* / protein phosphatase 1 regulatory inhibitor subunit 14A*  / complex / reaction
 ENSMUSG00000073557 Q8BG95 / Ppp1r12b / protein phosphatase 1, regulatory (inhibitor) subunit 12B / O60237* / protein phosphatase 1 regulatory subunit 12B*  / complex
 ENSMUSG00000030867 Plk1 / Q07832 / polo like kinase 1 / P53350*  / reaction






 

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