ENSMUSG00000014956


Mus musculus

Features
Gene ID: ENSMUSG00000014956
  
Biological name :Ppp1cb
  
Synonyms : P62141 / Ppp1cb / Serine/threonine-protein phosphatase PP1-beta catalytic subunit
  
Possible biological names infered from orthology : P62140 / protein phosphatase 1 catalytic subunit beta
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 32458843
Gene end: 32517433
  
Corresponding Affymetrix probe sets: 10520952 (MoGene1.0st)   1426205_at (Mouse Genome 430 2.0 Array)   1431328_at (Mouse Genome 430 2.0 Array)   1433540_x_at (Mouse Genome 430 2.0 Array)   1456462_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144047
Ensembl peptide - ENSMUSP00000144350
Ensembl peptide - ENSMUSP00000144167
Ensembl peptide - ENSMUSP00000015100
NCBI entrez gene - 19046     See in Manteia.
MGI - MGI:104871
RefSeq - NM_172707
RefSeq - XM_006503780
RefSeq Peptide - NP_766295
swissprot - A0A0J9YUU8
swissprot - P62141
swissprot - A0A0J9YUG2
Ensembl - ENSMUSG00000014956
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PPP1CBENSGALG00000010026Gallus gallus
 P62140ENSG00000213639Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62137 / Ppp1ca / protein phosphatase 1, catalytic subunit, alpha isoform / P62136* / protein phosphatase 1 catalytic subunit alpha*ENSMUSG0000004038587
P63087 / Ppp1cc / Serine/threonine-protein phosphatase PP1-gamma catalytic subunit / P36873* / protein phosphatase 1 catalytic subunit gamma*ENSMUSG0000000445585


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like
 IPR031675  Serine-threonine protein phosphatase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0005979 regulation of glycogen biosynthetic process IEA
 biological_processGO:0005981 regulation of glycogen catabolic process IEA
 biological_processGO:0006470 protein dephosphorylation IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0030155 regulation of cell adhesion ISS
 biological_processGO:0032922 circadian regulation of gene expression IDA
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000164 protein phosphatase type 1 complex IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0042587 glycogen granule IEA
 cellular_componentGO:0072357 PTW/PP1 phosphatase complex ISO
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IDA
 molecular_functionGO:0017018 myosin phosphatase activity ISS
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050115 myosin-light-chain-phosphatase activity ISO


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
RHO GTPases activate PKNs
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030867 Plk1 / Q07832 / polo like kinase 1 / P53350*  / reaction
 ENSMUSG00000019907 Q9DBR7 / Ppp1r12a / protein phosphatase 1, regulatory (inhibitor) subunit 12A / O14974* / protein phosphatase 1 regulatory subunit 12A*  / complex
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction
 ENSMUSG00000037166 Q91VC7 / Ppp1r14a / Protein phosphatase 1 regulatory subunit 14A / Q96A00* / protein phosphatase 1 regulatory inhibitor subunit 14A*  / reaction / complex
 ENSMUSG00000073557 Q8BG95 / Ppp1r12b / protein phosphatase 1, regulatory (inhibitor) subunit 12B / O60237* / protein phosphatase 1 regulatory subunit 12B*  / complex






 

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