ENSMUSG00000004455


Mus musculus

Features
Gene ID: ENSMUSG00000004455
  
Biological name :Ppp1cc
  
Synonyms : P63087 / Ppp1cc / Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
  
Possible biological names infered from orthology : P36873 / protein phosphatase 1 catalytic subunit gamma
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 122158278
Gene end: 122175273
  
Corresponding Affymetrix probe sets: 10525352 (MoGene1.0st)   10556764 (MoGene1.0st)   1450149_a_at (Mouse Genome 430 2.0 Array)   1452046_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099587
Ensembl peptide - ENSMUSP00000142415
Ensembl peptide - ENSMUSP00000143509
Ensembl peptide - ENSMUSP00000143146
Ensembl peptide - ENSMUSP00000143006
Ensembl peptide - ENSMUSP00000142700
Ensembl peptide - ENSMUSP00000142623
Ensembl peptide - ENSMUSP00000083474
NCBI entrez gene - 19047     See in Manteia.
NCBI entrez gene - 434233     See in Manteia.
MGI - MGI:104872
RefSeq - XM_006530200
RefSeq - NM_013636
RefSeq Peptide - NP_038664
swissprot - A0A0G2JE42
swissprot - A0A0G2JFF1
swissprot - A0A0G2JGC1
swissprot - P63087
swissprot - Q6ZWM8
swissprot - A0A0G2JEB0
swissprot - A0A0G2JF34
Ensembl - ENSMUSG00000004455
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1cabENSDARG00000071566Danio rerio
 PPP1CCENSDARG00000099226Danio rerio
 PPP1CCENSGALG00000004571Gallus gallus
 P36873ENSG00000186298Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62137 / Ppp1ca / protein phosphatase 1, catalytic subunit, alpha isoform / P62136* / protein phosphatase 1 catalytic subunit alpha*ENSMUSG0000004038592
P62141 / Ppp1cb / Serine/threonine-protein phosphatase PP1-beta catalytic subunit / P62140* / protein phosphatase 1 catalytic subunit beta*ENSMUSG0000001495686


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like
 IPR031675  Serine-threonine protein phosphatase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0006470 protein dephosphorylation ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0030182 neuron differentiation ISS
 biological_processGO:0032922 circadian regulation of gene expression IDA
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IMP
 biological_processGO:0046822 regulation of nucleocytoplasmic transport IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000164 protein phosphatase type 1 complex IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IDA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0072357 PTW/PP1 phosphatase complex ISS
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005521 lamin binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008157 protein phosphatase 1 binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IDA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding ISO


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ppp1cctm1Var/Ppp1cctm1Var
Genetic Background: involves: CD-1

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ppp1cctm1Lex/Ppp1cctm1Lex,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: 129S/SvEvBrd * FVB/NJ

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp1cctm1Lex/Ppp1cctm1Lex,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: 129S/SvEvBrd * FVB/NJ

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Ppp1cctm1Var/Ppp1cctm1Var
Genetic Background: involves: CD-1

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ppp1cctm1Var/Ppp1cctm1Var
Genetic Background: involves: CD-1

Allelic Composition: Ppp1cctm1Lex/Ppp1cctm1Lex,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: 129S/SvEvBrd * FVB/NJ

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp1cctm1Var/Ppp1cctm1Var
Genetic Background: involves: CD-1

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ppp1cctm1Var/Ppp1cctm1Var
Genetic Background: involves: CD-1

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp1cctm1Lex/Ppp1cctm1Lex,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: 129S/SvEvBrd * FVB/NJ

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp1cctm1Var/Ppp1cctm1Var
Genetic Background: involves: CD-1

 MP:0008279 arrest of spermiogenesis "block in the process by which a spermatid transforms into a functional spermatozoon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp1cctm1Var/Ppp1cctm1Var
Genetic Background: involves: CD-1

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Ppp1cctm1Var/Ppp1cctm1Var
Genetic Background: involves: CD-1

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp1cctm1Var/Ppp1cctm1Var
Genetic Background: involves: CD-1

 MP:0009236 pinhead sperm "a sperm head that is unusually oblong in shape and much smaller than normal; typically, pinhead sperm result when the centrioles from which the sperm tails develop are not correctly aligned opposite the developing acrosome so that sperm heads are lost and absorbed during epididymal transit" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp1cctm1Var/Ppp1cctm1Var
Genetic Background: involves: CD-1

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp1cctm1Lex/Ppp1cctm1Lex,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: 129S/SvEvBrd * FVB/NJ

 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp1cctm1Var/Ppp1cctm1Var
Genetic Background: involves: CD-1

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
Show

Allelic Composition: Ppp1cctm1Var/Ppp1cctm1Var
Genetic Background: involves: CD-1

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Ppp1cctm1Var/Ppp1cctm1Var
Genetic Background: involves: CD-1

Allelic Composition: Ppp1cctm1Lex/Ppp1cctm1Lex,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: 129S/SvEvBrd * FVB/NJ

 MP:0009833 absent sperm mitochondrial sheath "absence of the tightly packed helical sheath of ATP-producing mitochondria, normally found in the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Ppp1cctm1Var/Ppp1cctm1Var
Genetic Background: involves: CD-1

 MP:0009836 abnormal sperm principal piece morphology "any structural abnormality in the segment of the sperm flagellum where the mitochondrial sheath ends and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs; the principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece" [PMID:14581499]
Show

Allelic Composition: Ppp1cctm1Var/Ppp1cctm1Var
Genetic Background: involves: CD-1

 MP:0009839 multiflagellated sperm "presence of more than one sperm flagellum, displaying either one common origin from the sperm head or multiple origins from the same sperm head" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp1cctm1Var/Ppp1cctm1Var
Genetic Background: involves: CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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