ENSG00000186298


Homo sapiens

Features
Gene ID: ENSG00000186298
  
Biological name :PPP1CC
  
Synonyms : P36873 / PPP1CC / protein phosphatase 1 catalytic subunit gamma
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.11
Gene start: 110719680
Gene end: 110742939
  
Corresponding Affymetrix probe sets: 200726_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000448437
Ensembl peptide - ENSP00000447528
Ensembl peptide - ENSP00000448981
Ensembl peptide - ENSP00000482210
Ensembl peptide - ENSP00000335084
Ensembl peptide - ENSP00000341779
Ensembl peptide - ENSP00000447090
Ensembl peptide - ENSP00000447122
NCBI entrez gene - 5501     See in Manteia.
OMIM - 176914
RefSeq - XM_011538505
RefSeq - NM_001244974
RefSeq - NM_002710
RefSeq - XM_011538504
RefSeq Peptide - NP_002701
RefSeq Peptide - NP_001231903
swissprot - F8W1A0
swissprot - P36873
swissprot - A0A024RBP2
swissprot - A0A087WYY5
swissprot - F8VR82
swissprot - F8W0V8
swissprot - F8VYE8
swissprot - F8W0W8
Ensembl - ENSG00000186298
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1cabENSDARG00000071566Danio rerio
 PPP1CCENSDARG00000099226Danio rerio
 PPP1CCENSGALG00000004571Gallus gallus
 P63087ENSMUSG00000004455Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62136 / PPP1CA / protein phosphatase 1 catalytic subunit alphaENSG0000017253188
P62140 / PPP1CB / protein phosphatase 1 catalytic subunit betaENSG0000021363983


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like
 IPR031675  Serine-threonine protein phosphatase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0032922 circadian regulation of gene expression IEA
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IEA
 biological_processGO:0046822 regulation of nucleocytoplasmic transport IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000164 protein phosphatase type 1 complex IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0032991 protein-containing complex IMP
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0072357 PTW/PP1 phosphatase complex IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005521 lamin binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008157 protein phosphatase 1 binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IDA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Triglyceride catabolism
Downregulation of TGF-beta receptor signaling
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Circadian Clock
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105329 TGFB1 / P01137 / transforming growth factor beta 1  / complex / reaction
 ENSG00000101665 SMAD7 / O15105 / SMAD family member 7  / complex / reaction
 ENSG00000157077 O95405 / ZFYVE9 / zinc finger FYVE-type containing 9  / reaction / complex
 ENSG00000163513 P37173 / TGFBR2 / transforming growth factor beta receptor 2  / reaction / complex
 ENSG00000087074 O75807 / PPP1R15A / protein phosphatase 1 regulatory subunit 15A  / complex
 ENSG00000166819 PLIN1 / O60240 / perilipin 1  / reaction
 ENSG00000106799 P36897 / TGFBR1 / transforming growth factor beta receptor 1  / reaction / complex






 

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