ENSG00000172531


Homo sapiens

Features
Gene ID: ENSG00000172531
  
Biological name :PPP1CA
  
Synonyms : P62136 / PPP1CA / protein phosphatase 1 catalytic subunit alpha
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.2
Gene start: 67398183
Gene end: 67421183
  
Corresponding Affymetrix probe sets: 200846_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000438409
Ensembl peptide - ENSP00000365936
Ensembl peptide - ENSP00000439568
Ensembl peptide - ENSP00000431146
Ensembl peptide - ENSP00000326031
Ensembl peptide - ENSP00000350974
NCBI entrez gene - 5499     See in Manteia.
OMIM - 176875
RefSeq - NM_206873
RefSeq - NM_001008709
RefSeq - NM_002708
RefSeq Peptide - NP_001008709
RefSeq Peptide - NP_002699
RefSeq Peptide - NP_996756
swissprot - P62136
swissprot - A0A140VJS9
swissprot - F5H037
swissprot - F5H1L6
swissprot - E9PMD7
Ensembl - ENSG00000172531
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1caaENSDARG00000003486Danio rerio
 P62137ENSMUSG00000040385Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P36873 / PPP1CC / protein phosphatase 1 catalytic subunit gammaENSG0000018629887
P62140 / PPP1CB / protein phosphatase 1 catalytic subunit betaENSG0000021363983


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR006311  Twin-arginine translocation pathway, signal sequence
 IPR029052  Metallo-dependent phosphatase-like
 IPR031675  Serine-threonine protein phosphatase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0005979 regulation of glycogen biosynthetic process IEA
 biological_processGO:0005981 regulation of glycogen catabolic process IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010288 response to lead ion ISS
 biological_processGO:0016311 dephosphorylation IDA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0032091 negative regulation of protein binding ISS
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0035970 peptidyl-threonine dephosphorylation TAS
 biological_processGO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation ISS
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043153 entrainment of circadian clock by photoperiod ISS
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IC
 biological_processGO:0070262 peptidyl-serine dephosphorylation TAS
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1904886 beta-catenin destruction complex disassembly ISS
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0000164 protein phosphatase type 1 complex IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0042587 glycogen granule IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072357 PTW/PP1 phosphatase complex IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008157 protein phosphatase 1 binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity ISS
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion IDA


Pathways (from Reactome)
Pathway description
Triglyceride catabolism
DARPP-32 events
Downregulation of TGF-beta receptor signaling
Circadian Clock


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105329 TGFB1 / P01137 / transforming growth factor beta 1  / reaction / complex
 ENSG00000101665 SMAD7 / O15105 / SMAD family member 7  / reaction / complex
 ENSG00000157077 O95405 / ZFYVE9 / zinc finger FYVE-type containing 9  / reaction / complex
 ENSG00000163513 P37173 / TGFBR2 / transforming growth factor beta receptor 2  / reaction / complex
 ENSG00000087074 O75807 / PPP1R15A / protein phosphatase 1 regulatory subunit 15A  / complex
 ENSG00000166819 PLIN1 / O60240 / perilipin 1  / reaction
 ENSG00000106799 P36897 / TGFBR1 / transforming growth factor beta receptor 1  / reaction / complex






 

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