ENSG00000087074


Homo sapiens

Features
Gene ID: ENSG00000087074
  
Biological name :PPP1R15A
  
Synonyms : O75807 / PPP1R15A / protein phosphatase 1 regulatory subunit 15A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.33
Gene start: 48872392
Gene end: 48876057
  
Corresponding Affymetrix probe sets: 202014_at (Human Genome U133 Plus 2.0 Array)   37028_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000200453
Ensembl peptide - ENSP00000469239
NCBI entrez gene - 23645     See in Manteia.
OMIM - 611048
RefSeq - NM_014330
RefSeq Peptide - NP_055145
swissprot - O75807
swissprot - M0QXL1
Ensembl - ENSG00000087074
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1r15aENSDARG00000069135Danio rerio
 P17564ENSMUSG00000040435Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019523  Protein phosphatase 1, regulatory subunit 15A/B, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus TAS
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0032058 positive regulation of translational initiation in response to stress IC
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IDA
 biological_processGO:0032516 positive regulation of phosphoprotein phosphatase activity IDA
 biological_processGO:0034976 response to endoplasmic reticulum stress IDA
 biological_processGO:0035308 negative regulation of protein dephosphorylation IDA
 biological_processGO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation IDA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TAS
 biological_processGO:0070972 protein localization to endoplasmic reticulum IMP
 biological_processGO:1902310 positive regulation of peptidyl-serine dephosphorylation IDA
 biological_processGO:1903898 negative regulation of PERK-mediated unfolded protein response TAS
 biological_processGO:1903917 positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation TAS
 cellular_componentGO:0000164 protein phosphatase type 1 complex IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane NAS
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008157 protein phosphatase 1 binding IPI
 molecular_functionGO:0019888 protein phosphatase regulator activity IC
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0072542 protein phosphatase activator activity IC


Pathways (from Reactome)
Pathway description
Downregulation of TGF-beta receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105329 TGFB1 / P01137 / transforming growth factor beta 1  / reaction / complex
 ENSG00000101665 SMAD7 / O15105 / SMAD family member 7  / complex / reaction
 ENSG00000157077 O95405 / ZFYVE9 / zinc finger FYVE-type containing 9  / reaction / complex
 ENSG00000163513 P37173 / TGFBR2 / transforming growth factor beta receptor 2  / reaction / complex
 ENSG00000172531 P62136 / PPP1CA / protein phosphatase 1 catalytic subunit alpha  / complex
 ENSG00000213639 P62140 / PPP1CB / protein phosphatase 1 catalytic subunit beta  / complex
 ENSG00000186298 P36873 / PPP1CC / protein phosphatase 1 catalytic subunit gamma  / complex
 ENSG00000106799 P36897 / TGFBR1 / transforming growth factor beta receptor 1  / complex / reaction






 

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