ENSG00000157077


Homo sapiens

Features
Gene ID: ENSG00000157077
  
Biological name :ZFYVE9
  
Synonyms : O95405 / ZFYVE9 / zinc finger FYVE-type containing 9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p32.3
Gene start: 52142094
Gene end: 52346686
  
Corresponding Affymetrix probe sets: 204893_s_at (Human Genome U133 Plus 2.0 Array)   208446_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000287727
Ensembl peptide - ENSP00000349737
Ensembl peptide - ENSP00000360647
NCBI entrez gene - 9372     See in Manteia.
OMIM - 603755
RefSeq - XM_017002845
RefSeq - NM_004799
RefSeq - NM_007324
RefSeq - XM_011542437
RefSeq Peptide - NP_004790
RefSeq Peptide - NP_015563
swissprot - O95405
Ensembl - ENSG00000157077
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zfyve9aENSDARG00000101903Danio rerio
 zfyve9bENSDARG00000100764Danio rerio
 ZFYVE9ENSGALG00000010613Gallus gallus
 Zfyve9ENSMUSG00000034557Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7Z3T8 / ZFYVE16 / zinc finger FYVE-type containing 16ENSG0000003931937
Q9Y2I7 / PIKFYVE / phosphoinositide kinase, FYVE-type zinc finger containingENSG0000011502013
Q9HCC9 / ZFYVE28 / zinc finger FYVE-type containing 28ENSG000001597338
Q9BQ24 / ZFYVE21 / zinc finger FYVE-type containing 21ENSG000001007115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000306  FYVE zinc finger
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017455  Zinc finger, FYVE-related
 IPR022557  Domain of unknown function DUF3480
 IPR024608  Smad anchor for receptor activation, Smad-binding domain
 IPR035438  Zinc finger FYVE domain containing protein, SARA/endofin
 IPR037145  Smad anchor for receptor activation, Smad-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006897 endocytosis NAS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007183 SMAD protein complex assembly IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome NAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0032991 protein-containing complex IMP
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005545 1-phosphatidylinositol binding IDA
 molecular_functionGO:0008236 serine-type peptidase activity NAS
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105329 TGFB1 / P01137 / transforming growth factor beta 1  / reaction / complex
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / reaction
 ENSG00000186298 P36873 / PPP1CC / protein phosphatase 1 catalytic subunit gamma  / complex / reaction
 ENSG00000087074 O75807 / PPP1R15A / protein phosphatase 1 regulatory subunit 15A  / complex / reaction
 ENSG00000106799 P36897 / TGFBR1 / transforming growth factor beta receptor 1  / complex / reaction
 ENSG00000163513 P37173 / TGFBR2 / transforming growth factor beta receptor 2  / reaction / complex
 ENSG00000101665 SMAD7 / O15105 / SMAD family member 7  / reaction / complex
 ENSG00000172531 P62136 / PPP1CA / protein phosphatase 1 catalytic subunit alpha  / complex / reaction
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction
 ENSG00000213639 P62140 / PPP1CB / protein phosphatase 1 catalytic subunit beta  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr