ENSG00000039319


Homo sapiens

Features
Gene ID: ENSG00000039319
  
Biological name :ZFYVE16
  
Synonyms : Q7Z3T8 / ZFYVE16 / zinc finger FYVE-type containing 16
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q14.1
Gene start: 80408013
Gene end: 80479350
  
Corresponding Affymetrix probe sets: 1554638_at (Human Genome U133 Plus 2.0 Array)   1555011_at (Human Genome U133 Plus 2.0 Array)   1555982_at (Human Genome U133 Plus 2.0 Array)   203651_at (Human Genome U133 Plus 2.0 Array)   240859_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426536
Ensembl peptide - ENSP00000426500
Ensembl peptide - ENSP00000426848
Ensembl peptide - ENSP00000337159
Ensembl peptide - ENSP00000421785
Ensembl peptide - ENSP00000422356
Ensembl peptide - ENSP00000423663
NCBI entrez gene - 9765     See in Manteia.
OMIM - 608880
RefSeq - XM_017010096
RefSeq - NM_014733
RefSeq - XM_005248632
RefSeq - XM_011543753
RefSeq - XM_017010091
RefSeq - XM_017010092
RefSeq - XM_017010093
RefSeq - XM_017010094
RefSeq - XM_017010095
RefSeq - NM_001105251
RefSeq - NM_001284236
RefSeq Peptide - NP_055548
RefSeq Peptide - NP_001098721
RefSeq Peptide - NP_001271165
swissprot - H0Y8R0
swissprot - D6RC80
swissprot - Q7Z3T8
swissprot - H0YAA4
swissprot - H0YAB1
Ensembl - ENSG00000039319
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zfyve16ENSDARG00000075747Danio rerio
 ZFYVE16ENSGALG00000015576Gallus gallus
 Q80U44ENSMUSG00000021706Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O95405 / ZFYVE9 / zinc finger FYVE-type containing 9ENSG0000015707734
Q9Y2I7 / PIKFYVE / phosphoinositide kinase, FYVE-type zinc finger containingENSG0000011502013
Q9HCC9 / ZFYVE28 / zinc finger FYVE-type containing 28ENSG000001597338
Q9BQ24 / ZFYVE21 / zinc finger FYVE-type containing 21ENSG000001007115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000306  FYVE zinc finger
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017165  Zinc finger FYVE domain-containing protein, endofin
 IPR017455  Zinc finger, FYVE-related
 IPR022557  Domain of unknown function DUF3480
 IPR035438  Zinc finger FYVE domain containing protein, SARA/endofin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006622 protein targeting to lysosome IMP
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0016050 vesicle organization NAS
 biological_processGO:0016197 endosomal transport IMP
 biological_processGO:0030100 regulation of endocytosis TAS
 biological_processGO:0030509 BMP signaling pathway TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005545 1-phosphatidylinositol binding IDA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA
 molecular_functionGO:0008565 protein transporter activity IMP
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121989 ACVR2A / P27037 / activin A receptor type 2A  / complex / reaction
 ENSG00000138696 BMPR1B / O00238 / bone morphogenetic protein receptor type 1B  / complex / reaction
 ENSG00000204217 BMPR2 / Q13873 / bone morphogenetic protein receptor type 2  / complex / reaction
 ENSG00000114739 ACVR2B / Q13705 / activin A receptor type 2B  / complex / reaction
 ENSG00000113658 SMAD5 / Q99717 / SMAD family member 5  / complex / reaction
 ENSG00000107779 BMPR1A / P36894 / bone morphogenetic protein receptor type 1A  / reaction / complex
 ENSG00000170365 SMAD1 / Q15797 / SMAD family member 1  / complex / reaction
 ENSG00000125845 BMP2 / P12643 / bone morphogenetic protein 2  / complex / reaction
 ENSG00000120693 SMAD9 / O15198 / SMAD family member 9  / reaction / complex






 

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