ENSG00000027869


Homo sapiens

Features
Gene ID: ENSG00000027869
  
Biological name :SH2D2A
  
Synonyms : Q9NP31 / SH2D2A / SH2 domain containing 2A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q23.1
Gene start: 156806243
Gene end: 156816862
  
Corresponding Affymetrix probe sets: 207351_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357181
Ensembl peptide - ENSP00000357182
Ensembl peptide - ENSP00000376123
NCBI entrez gene - 9047     See in Manteia.
OMIM - 604514
RefSeq - NM_003975
RefSeq - XM_017002767
RefSeq - NM_001161441
RefSeq - NM_001161442
RefSeq - NM_001161443
RefSeq - NM_001161444
RefSeq - XM_006711615
RefSeq - XM_017002762
RefSeq - XM_017002763
RefSeq - XM_017002764
RefSeq - XM_017002765
RefSeq - XM_017002766
RefSeq Peptide - NP_001154914
RefSeq Peptide - NP_001154915
RefSeq Peptide - NP_001154916
RefSeq Peptide - NP_003966
RefSeq Peptide - NP_001154913
swissprot - Q9NP31
Ensembl - ENSG00000027869
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch73-109i22.2ENSDARG00000089983Danio rerio
 ENSGALG00000044505Gallus gallus
 Q9QXK9ENSMUSG00000028071Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SH2D7 / A6NKC9 / SH2 domain containing 7ENSG0000018347624
HSH2D / Q96JZ2 / hematopoietic SH2 domain containingENSG0000019668418
Q9H788 / SH2D4A / SH2 domain containing 4AENSG0000010461114
Q5SQS7 / SH2D4B / SH2 domain containing 4BENSG000001782176


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR035884  SH2D2A, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
VEGFA-VEGFR2 Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000167601 AXL / P30530 / AXL receptor tyrosine kinase  / reaction / complex
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / reaction / complex
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / reaction / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / reaction / complex
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction






 

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