Manteia

ENSMUSG00000019312

Mus musculus

Features

Gene ID:	ENSMUSG00000019312

Biological name :	Grb7

Synonyms :	Grb7 / Growth factor receptor-bound protein 7 / Q03160

Possible biological names infered from orthology :	Q14451

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	D
Gene start:	98446394
Gene end:	98455373

Corresponding Affymetrix probe sets:	10380927 (MoGene1.0st) 1448227_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000119926 Ensembl peptide - ENSMUSP00000019456 NCBI entrez gene - 14786 See in Manteia. MGI - MGI:102683 RefSeq - NM_010346 RefSeq - XM_006532233 RefSeq Peptide - NP_034476 swissprot - A2A555 swissprot - Q03160 Ensembl - ENSMUSG00000019312

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
si:ch211-253b1.3	ENSDARG00000042726	Danio rerio
GRB7	ENSGALG00000036500	Gallus gallus
GRB7	ENSG00000141738	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Grb10 / Q60760 / Growth factor receptor-bound protein 10 / Q13322*	ENSMUSG00000020176	51
Grb14 / Q9JLM9 / Growth factor receptor-bound protein 14 / Q14449*	ENSMUSG00000026888	48
Q8R5A3 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / amyloid beta precursor protein binding family B member 1 interacting protein*	ENSMUSG00000026786	23
Raph1 / Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 / Q70E73*	ENSMUSG00000026014	23

Protein motifs (from Interpro)

Interpro ID	Name
IPR000159	Ras-associating (RA) domain
IPR000980	SH2 domain
IPR001849	Pleckstrin homology domain
IPR011993	PH-like domain superfamily
IPR015042	BPS (Between PH and SH2) domain
IPR029071	Ubiquitin-like domain superfamily
IPR035032	Growth factor receptor-bound protein 7
IPR036860	SH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0009967	positive regulation of signal transduction	IEA
biological_process	GO:0017148	negative regulation of translation	IMP
biological_process	GO:0030335	positive regulation of cell migration	IEA
biological_process	GO:0034063	stress granule assembly	IMP
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005925	focal adhesion	ISS
cellular_component	GO:0010494	cytoplasmic stress granule	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0030054	cell junction	IEA
cellular_component	GO:0042995	cell projection	IEA
molecular_function	GO:0003723	RNA binding	IEA
molecular_function	GO:0005070	SH3/SH2 adaptor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008289	lipid binding	IEA
molecular_function	GO:0019901	protein kinase binding	IEA
molecular_function	GO:0035091	phosphatidylinositol binding	IEA
molecular_function	GO:0042802	identical protein binding	IEA

Pathways (from Reactome)

Pathway description

GRB7 events in ERBB2 signaling

Signaling by SCF-KIT

Downstream signal transduction

Tie2 Signaling

RET signaling

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001312	abnormal cornea morphology	"malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0001319	irregularly shaped pupil	"shape defects in the aperture of the iris through which light rays enter the eye, usually circular " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0001322	abnormal iris morphology	"structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0003345	decreased number of ribs	"fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000027316	Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*	/ complex / reaction
ENSMUSG00000002664	Pspn / persephin / O60542*	/ complex / reaction
ENSMUSG00000022144	Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*	/ reaction / complex
ENSMUSG00000024366	Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*	/ complex / reaction
ENSMUSG00000062312	Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*	/ reaction / complex
ENSMUSG00000022309	Angpt1 / O08538 / Angiopoietin-1 / Q15389*	/ reaction / complex
ENSMUSG00000030110	Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*	/ reaction / complex
ENSMUSG00000000489	Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*	/ reaction / complex
ENSMUSG00000024620	Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*	/ reaction / complex
ENSMUSG00000018166	Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*	/ complex / reaction
ENSMUSG00000005672	Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*	/ reaction / complex
ENSMUSG00000025856	Pdgfa / platelet derived growth factor subunit A / P04085*	/ complex / reaction
ENSMUSG00000029231	P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*	/ complex / reaction
ENSMUSG00000039481	Nrtn / P97463 / Neurturin / Q99748*	/ reaction / complex
ENSMUSG00000019966	Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*	/ complex / reaction
ENSMUSG00000006386	Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*	/ reaction / complex
ENSMUSG00000025089	Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*	/ reaction / complex
ENSMUSG00000022103	Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*	/ complex / reaction
ENSMUSG00000028539	Artn / Q9Z0L2 / Artemin / Q5T4W7*	/ reaction / complex
ENSMUSG00000060275	Nrg2 / neuregulin 2 / O14511*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr