ENSMUSG00000026014


Mus musculus

Features
Gene ID: ENSMUSG00000026014
  
Biological name :Raph1
  
Synonyms : Raph1 / Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
  
Possible biological names infered from orthology : Q70E73
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C2
Gene start: 60482292
Gene end: 60567104
  
Corresponding Affymetrix probe sets: 10355050 (MoGene1.0st)   1434302_at (Mouse Genome 430 2.0 Array)   1434303_at (Mouse Genome 430 2.0 Array)   1456918_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027168
Ensembl peptide - ENSMUSP00000087763
Ensembl peptide - ENSMUSP00000120638
Ensembl peptide - ENSMUSP00000121023
Ensembl peptide - ENSMUSP00000138682
NCBI entrez gene - 77300     See in Manteia.
MGI - MGI:1924550
RefSeq - XM_006496322
RefSeq - XM_006496324
RefSeq - XM_006496326
RefSeq - XM_006496327
RefSeq - XM_017312876
RefSeq - XM_006496323
RefSeq - NM_001045513
RefSeq Peptide - NP_001038978
swissprot - S4R2K5
swissprot - F2Z4B7
swissprot - G5E867
swissprot - F2Z3U3
swissprot - F2Z3X7
Ensembl - ENSMUSG00000026014
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 raph1aENSDARG00000006301Danio rerio
 raph1bENSDARG00000061732Danio rerio
 ENSGALG00000031688Gallus gallus
 RAPH1ENSG00000173166Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8R5A3 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / amyloid beta precursor protein binding family B member 1 interacting protein*ENSMUSG0000002678624
Grb14 / Q9JLM9 / Growth factor receptor-bound protein 14 / Q14449*ENSMUSG0000002688811
Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*ENSMUSG0000001931210
Grb10 / Q60760 / Growth factor receptor-bound protein 10 / Q13322*ENSMUSG0000002017610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0048675 axon extension IMP
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0031252 cell leading edge IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Raph1tm1.1Makr/Raph1tm1.1Makr,Tmem163Tg(ACTB-cre)2Mrt/0,Tg(Dct-LacZ)A12Jkn/Tg(Dct-LacZ)A12Jkn
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA * FVB/N

Allelic Composition: Raph1tm1.1Makr/Raph1tm1.1Makr,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: C57BL/6 * C57BL/6NTac * FVB/N

Allelic Composition: Raph1tm1.1Makr/Raph1tm1.1Makr,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

 MP:0000492 abnormal rectum morphology "structural aberration in the terminal portion of the intestinal tube adjacent to the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Piezo1tm1c(KOMP)Wtsi/Piezo1tm1c(KOMP)Wtsi,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Piezo1tm1c(KOMP)Wtsi/Piezo1tm1c(KOMP)Wtsi,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Piezo1tm1c(KOMP)Wtsi/Piezo1tm1c(KOMP)Wtsi,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Raph1tm1.1Makr/Raph1tm1.1Makr,Tmem163Tg(ACTB-cre)2Mrt/0,Tg(Dct-LacZ)A12Jkn/Tg(Dct-LacZ)A12Jkn
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA * FVB/N

Allelic Composition: Raph1tm1.1Makr/Raph1tm1.1Makr,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: C57BL/6 * C57BL/6NTac * FVB/N

Allelic Composition: Raph1tm1.1Makr/Raph1tm1.1Makr,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Piezo1tm1c(KOMP)Wtsi/Piezo1tm1c(KOMP)Wtsi,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Raph1tm1.1Makr/Raph1tm1.1Makr,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Piezo1tm1c(KOMP)Wtsi/Piezo1tm1c(KOMP)Wtsi,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Piezo1tm1c(KOMP)Wtsi/Piezo1tm1c(KOMP)Wtsi,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003288 intestinal edema "an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Piezo1tm1c(KOMP)Wtsi/Piezo1tm1c(KOMP)Wtsi,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Piezo1tm1c(KOMP)Wtsi/Piezo1tm1c(KOMP)Wtsi,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Piezo1tm1c(KOMP)Wtsi/Piezo1tm1c(KOMP)Wtsi,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Raph1tm1.1Makr/Raph1tm1.1Makr,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Raph1tm1.1Makr/Raph1tm1.1Makr,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: C57BL/6 * C57BL/6NTac * FVB/N

Allelic Composition: Raph1tm1.1Makr/Raph1tm1.1Makr,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Raph1tm1.1Makr/Raph1tm1.1Makr,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

 MP:0011707 impaired fibroblast cell migration "failure of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
Show

Allelic Composition: Lmnatm1.2Yxz/Lmnatm1.2Yxz
Genetic Background: involves: 129S * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0012023 decreased melanocyte number "reduced number of the cells that produce pigment" [MGI:llw2]
Show

Allelic Composition: Raph1tm1.1Makr/Raph1tm1.1Makr,Tmem163Tg(ACTB-cre)2Mrt/0,Tg(Dct-LacZ)A12Jkn/Tg(Dct-LacZ)A12Jkn
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA * FVB/N

 MP:0013663 increased myeloid cell number "greater than the expected number of cells of the myeloid lineage" [CL:0000763]
Show

Allelic Composition: Piezo1tm1c(KOMP)Wtsi/Piezo1tm1c(KOMP)Wtsi,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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