ENSMUSG00000024366


Mus musculus

Features
Gene ID: ENSMUSG00000024366
  
Biological name :Gfra3
  
Synonyms : GDNF family receptor alpha-3 / Gfra3 / O35118
  
Possible biological names infered from orthology : O60609
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B1
Gene start: 34689903
Gene end: 34720387
  
Corresponding Affymetrix probe sets: 10458183 (MoGene1.0st)   1418880_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025224
NCBI entrez gene - 14587     See in Manteia.
MGI - MGI:1201403
RefSeq - NM_010280
RefSeq Peptide - NP_034410
swissprot - O35118
Ensembl - ENSMUSG00000024366
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gfra3ENSDARG00000087704Danio rerio
 GFRA3ENSGALG00000007620Gallus gallus
 GFRA3ENSG00000146013Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*ENSMUSG0000002210335
Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*ENSMUSG0000002508932
Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*ENSMUSG0000002731621


Protein motifs (from Interpro)
Interpro ID Name
 IPR003438  Glial cell line-derived neurotrophic factor receptor
 IPR003505  Glial cell line-derived neurotrophic factor receptor, alpha 3
 IPR016017  GDNF/GAS1
 IPR037193  GDNF receptor alpha


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0048485 sympathetic nervous system development IMP
 biological_processGO:0048666 neuron development IMP
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008046 axon guidance receptor activity IMP
 molecular_functionGO:0015026 coreceptor activity TAS


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001007 abnormal sympathetic system morphology "malformation of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gfra3tm1Jmi/Gfra3tm1Jmi
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001008 abnormal sympathetic ganglia morphology "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048]
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Allelic Composition: Gfra3tm1Jmi/Gfra3tm1Jmi
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atxn7tm1Hzo/Atxn7+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gfra3tm1Hmd/Gfra3tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr

Allelic Composition: Gfra3tm1Jmi/Gfra3tm1Jmi
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001014 absent superior cervical ganglion "missing group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17792]
Show

Allelic Composition: Gfra3tm1Hmd/Gfra3tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr

 MP:0001015 small superior cervical ganglion "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gfra3tm1Hmd/Gfra3tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr

Allelic Composition: Gfra3tm1Jmi/Gfra3tm1Jmi
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001025 abnormal sympathetic neuron morphology "malformation or anomalous development of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gfra3tm1Jmi/Gfra3tm1Jmi
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001344 blepharoptosis "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gfra3tm1Jmi/Gfra3tm1Jmi
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Gfra3tm1Wss/Gfra3tm1Wss
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Gfra3tm1Hmd/Gfra3tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atxn7tm1Hzo/Atxn7+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gfra3tm1Hmd/Gfra3tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr

 MP:0009284 abnormal sympathetic neuron innervation "defective or incomplete supply of nerve fibers to sympathetic termini" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gfra3tm1Hmd/Gfra3tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr

 MP:0009561 superior cervical ganglion degeneration "retrogressive pathological change or loss of the largest group of paravertebral ganglia of the sympathetic trunk which normally lies at the base of the skull and innervates the head and neck" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gfra3tm1Hmd/Gfra3tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002664 Pspn / persephin / O60542*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000019312 Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*  / complex / reaction
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / complex / reaction
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / complex / reaction
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex
 ENSMUSG00000041351 A2ALS5 / Rap1gap / Mus musculus Rap1 GTPase-activating protein (Rap1gap), transcript variant 5, mRNA. / P47736* / RAP1 GTPase activating protein*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / reaction / complex
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / reaction / complex
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / reaction / complex
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / complex / reaction
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex / reaction
 ENSMUSG00000020176 Grb10 / Q60760 / Growth factor receptor-bound protein 10 / Q13322*  / reaction / complex






 

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