ENSMUSG00000041351


Mus musculus

Features
Gene ID: ENSMUSG00000041351
  
Biological name :Rap1gap
  
Synonyms : A2ALS5 / Mus musculus Rap1 GTPase-activating protein (Rap1gap), transcript variant 5, mRNA. / Rap1gap
  
Possible biological names infered from orthology : P47736 / RAP1 GTPase activating protein
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 137664726
Gene end: 137729861
  
Corresponding Affymetrix probe sets: 10509410 (MoGene1.0st)   1428443_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095448
Ensembl peptide - ENSMUSP00000042473
Ensembl peptide - ENSMUSP00000101461
Ensembl peptide - ENSMUSP00000123561
Ensembl peptide - ENSMUSP00000122315
Ensembl peptide - ENSMUSP00000115391
NCBI entrez gene - 110351     See in Manteia.
MGI - MGI:109338
RefSeq - XM_006538483
RefSeq - NM_001256218
RefSeq - NM_001331215
RefSeq - NM_029563
RefSeq - XM_006538475
RefSeq - XM_006538476
RefSeq - XM_006538478
RefSeq - XM_006538480
RefSeq - XM_006538481
RefSeq - XM_006538482
RefSeq - NM_001081155
RefSeq Peptide - NP_001074624
RefSeq Peptide - NP_001243147
RefSeq Peptide - NP_001318144
RefSeq Peptide - NP_083839
swissprot - A2ALS7
swissprot - A2ALS2
swissprot - A2ALS5
swissprot - A2ALS4
swissprot - A2ALS3
Ensembl - ENSMUSG00000041351
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rap1gapENSDARG00000056554Danio rerio
 si:dkey-166d12.2ENSDARG00000053272Danio rerio
 RAP1GAP1ENSGALG00000014701Gallus gallus
 P47736ENSG00000076864Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5SVL6 / Rap1gap2 / Rap1 GTPase-activating protein 2 / Q684P5*ENSMUSG0000003880747
Q80TE4 / Sipa1l2 / Mus musculus signal-induced proliferation-associated 1 like 2 (Sipa1l2), transcript variant 2, mRNA. / Q9P2F8* / signal induced proliferation associated 1 like 2*ENSMUSG0000000199528
Q8C0T5 / Sipa1l1 / Signal-induced proliferation-associated 1-like protein 1 / O43166* / signal induced proliferation associated 1 like 1*ENSMUSG0000004270027
G3X9J0 / Sipa1l3 / signal-induced proliferation-associated 1 like 3 / O60292*ENSMUSG0000003058327
Sipa1 / signal-induced proliferation-associated 1 / Q96FS4*ENSMUSG0000005691723
Garnl3 / Q3V0G7 / Mus musculus GTPase activating RANGAP domain-like 3 (Garnl3), transcript variant 2, mRNA. / Q5VVW2* / GTPase activating Rap/RanGAP domain like 3*ENSMUSG0000003886022
A3KGS3 / Ralgapa2 / Ral GTPase-activating protein subunit alpha-2 / Q2PPJ7* / Ral GTPase activating protein catalytic alpha subunit 2*ENSMUSG0000003711013
Q6GYP7 / Ralgapa1 / Ral GTPase activating protein, alpha subunit 1 / Q6GYQ0* / Ral GTPase activating protein catalytic alpha subunit 1*ENSMUSG0000002102713
Tsc2 / tuberous sclerosis 2 / P49815* / TSC complex subunit 2*ENSMUSG0000000249610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000331  Rap GTPase activating protein domain
 IPR003109  GoLoco motif
 IPR035974  Rap/Ran-GAP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0022409 positive regulation of cell-cell adhesion IMP
 biological_processGO:0043087 regulation of GTPase activity ISO
 biological_processGO:0043547 positive regulation of GTPase activity ISO
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0050766 positive regulation of phagocytosis IMP
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction IEA
 biological_processGO:1903697 negative regulation of microvillus assembly ISO
 biological_processGO:1904425 negative regulation of GTP binding IEA
 biological_processGO:1904442 negative regulation of thyroid gland epithelial cell proliferation IEA
 biological_processGO:1990792 cellular response to glial cell derived neurotrophic factor IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0005096 GTPase activator activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017016 Ras GTPase binding ISO
 molecular_functionGO:0030695 GTPase regulator activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISO


Pathways (from Reactome)
Pathway description
Rap1 signalling
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002664 Pspn / persephin / O60542*  / reaction / complex
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / reaction / complex
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / complex / reaction
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / complex / reaction
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / reaction / complex
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / reaction / complex
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / complex / reaction
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / reaction
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / reaction
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / complex / reaction
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex / reaction






 

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