ENSMUSG00000056917


Mus musculus

Features
Gene ID: ENSMUSG00000056917
  
Biological name :Sipa1
  
Synonyms : signal-induced proliferation-associated 1 / Sipa1
  
Possible biological names infered from orthology : Q96FS4
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 5651185
Gene end: 5663707
  
Corresponding Affymetrix probe sets: 10465132 (MoGene1.0st)   1416206_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073618
Ensembl peptide - ENSMUSP00000079637
Ensembl peptide - ENSMUSP00000128208
Ensembl peptide - ENSMUSP00000132345
NCBI entrez gene - 20469     See in Manteia.
MGI - MGI:107576
RefSeq - XM_017318104
RefSeq - NM_001164480
RefSeq - NM_001164481
RefSeq - NM_001164482
RefSeq - NM_001164568
RefSeq - NM_011379
RefSeq - XM_017318098
RefSeq - XM_017318099
RefSeq - XM_017318100
RefSeq - XM_017318101
RefSeq - XM_017318102
RefSeq - XM_017318103
RefSeq Peptide - NP_001157952
RefSeq Peptide - NP_001157953
RefSeq Peptide - NP_001157954
RefSeq Peptide - NP_001158040
RefSeq Peptide - NP_035509
swissprot - E9Q0Y4
Ensembl - ENSMUSG00000056917
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zmp:0000001168ENSDARG00000076697Danio rerio
 SIPA1ENSG00000213445Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80TE4 / Sipa1l2 / Mus musculus signal-induced proliferation-associated 1 like 2 (Sipa1l2), transcript variant 2, mRNA. / Q9P2F8* / signal induced proliferation associated 1 like 2*ENSMUSG0000000199544
Q8C0T5 / Sipa1l1 / Signal-induced proliferation-associated 1-like protein 1 / O43166* / signal induced proliferation associated 1 like 1*ENSMUSG0000004270043
G3X9J0 / Sipa1l3 / signal-induced proliferation-associated 1 like 3 / O60292*ENSMUSG0000003058342
Garnl3 / Q3V0G7 / Mus musculus GTPase activating RANGAP domain-like 3 (Garnl3), transcript variant 2, mRNA. / Q5VVW2* / GTPase activating Rap/RanGAP domain like 3*ENSMUSG0000003886020
Q5SVL6 / Rap1gap2 / Rap1 GTPase-activating protein 2 / Q684P5*ENSMUSG0000003880718
A2ALS5 / Rap1gap / Mus musculus Rap1 GTPase-activating protein (Rap1gap), transcript variant 5, mRNA. / P47736* / RAP1 GTPase activating protein*ENSMUSG0000004135116
Q6GYP7 / Ralgapa1 / Ral GTPase activating protein, alpha subunit 1 / Q6GYQ0* / Ral GTPase activating protein catalytic alpha subunit 1*ENSMUSG0000002102714
A3KGS3 / Ralgapa2 / Ral GTPase-activating protein subunit alpha-2 / Q2PPJ7* / Ral GTPase activating protein catalytic alpha subunit 2*ENSMUSG0000003711014
Tsc2 / tuberous sclerosis 2 / P49815* / TSC complex subunit 2*ENSMUSG0000000249610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000331  Rap GTPase activating protein domain
 IPR001478  PDZ domain
 IPR035974  Rap/Ran-GAP superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042631 cellular response to water deprivation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction IEA
 cellular_componentGO:0030133 transport vesicle IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA


Pathways (from Reactome)
Pathway description
Rap1 signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Sipa1tm1Nm/Sipa1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Sipa1tm1Nm/Sipa1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sipa1tm1Nm/Sipa1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
Show

Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005481 chronic myelocytic leukemia "a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Sipa1tm1Nm/Sipa1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / reaction
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / reaction






 

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