ENSG00000213445


Homo sapiens

Features
Gene ID: ENSG00000213445
  
Biological name :SIPA1
  
Synonyms : Q96FS4 / signal-induced proliferation-associated 1 / SIPA1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.1
Gene start: 65638097
Gene end: 65650930
  
Corresponding Affymetrix probe sets: 204164_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377771
Ensembl peptide - ENSP00000434362
Ensembl peptide - ENSP00000436269
Ensembl peptide - ENSP00000436683
Ensembl peptide - ENSP00000433686
NCBI entrez gene - 6494     See in Manteia.
OMIM - 602180
RefSeq - XM_011545214
RefSeq - NM_006747
RefSeq - NM_153253
RefSeq - XM_005274189
RefSeq Peptide - NP_006738
RefSeq Peptide - NP_694985
swissprot - F6RY50
swissprot - Q96FS4
swissprot - E9PIB3
Ensembl - ENSG00000213445
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zmp:0000001168ENSDARG00000076697Danio rerio
 Sipa1ENSMUSG00000056917Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O60292 / SIPA1L3 / signal induced proliferation associated 1 like 3ENSG0000010573843
Q9P2F8 / SIPA1L2 / signal induced proliferation associated 1 like 2ENSG0000011699143
O43166 / SIPA1L1 / signal induced proliferation associated 1 like 1ENSG0000019755543
GARNL3 / Q5VVW2 / GTPase activating Rap/RanGAP domain like 3ENSG0000013689521
Q684P5 / RAP1GAP2 / RAP1 GTPase activating protein 2ENSG0000013235919
P47736 / RAP1GAP / RAP1 GTPase activating proteinENSG0000007686417
Q2PPJ7 / RALGAPA2 / Ral GTPase activating protein catalytic alpha subunit 2ENSG0000018855914
Q6GYQ0 / RALGAPA1 / Ral GTPase activating protein catalytic alpha subunit 1ENSG0000017437314
TSC2 / P49815 / TSC complex subunit 2ENSG0000010319711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000331  Rap GTPase activating protein domain
 IPR001478  PDZ domain
 IPR035974  Rap/Ran-GAP superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization NAS
 biological_processGO:0007162 negative regulation of cell adhesion NAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0030308 negative regulation of cell growth NAS
 biological_processGO:0035556 intracellular signal transduction NAS
 biological_processGO:0042631 cellular response to water deprivation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045786 negative regulation of cell cycle NAS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA


Pathways (from Reactome)
Pathway description
Rap1 signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / reaction
 ENSG00000127314 RAP1B / P61224 / RAP1B, member of RAS oncogene family  / reaction






 

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