ENSG00000116991


Homo sapiens

Features
Gene ID: ENSG00000116991
  
Biological name :SIPA1L2
  
Synonyms : Q9P2F8 / signal induced proliferation associated 1 like 2 / SIPA1L2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q42.2
Gene start: 232397965
Gene end: 232561558
  
Corresponding Affymetrix probe sets: 1559469_s_at (Human Genome U133 Plus 2.0 Array)   225056_at (Human Genome U133 Plus 2.0 Array)   233587_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262861
Ensembl peptide - ENSP00000309102
Ensembl peptide - ENSP00000355589
NCBI entrez gene - 57568     See in Manteia.
OMIM - 611609
RefSeq - XM_017001898
RefSeq - NM_020808
RefSeq - XM_017001896
RefSeq - XM_017001897
RefSeq - XM_005273211
RefSeq - XM_005273212
RefSeq - XM_005273213
RefSeq - XM_011544243
RefSeq Peptide - NP_065859
swissprot - Q9P2F8
Ensembl - ENSG00000116991
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sipa1l2ENSDARG00000061640Danio rerio
 SIPA1L2ENSGALG00000037506Gallus gallus
 Q80TE4ENSMUSG00000001995Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O43166 / SIPA1L1 / signal induced proliferation associated 1 like 1ENSG0000019755553
O60292 / SIPA1L3 / signal induced proliferation associated 1 like 3ENSG0000010573847
SIPA1 / Q96FS4 / signal-induced proliferation-associated 1ENSG0000021344526
GARNL3 / Q5VVW2 / GTPase activating Rap/RanGAP domain like 3ENSG0000013689514
P47736 / RAP1GAP / RAP1 GTPase activating proteinENSG0000007686413
Q2PPJ7 / RALGAPA2 / Ral GTPase activating protein catalytic alpha subunit 2ENSG0000018855912
Q6GYQ0 / RALGAPA1 / Ral GTPase activating protein catalytic alpha subunit 1ENSG0000017437312
Q684P5 / RAP1GAP2 / RAP1 GTPase activating protein 2ENSG0000013235912
TSC2 / P49815 / TSC complex subunit 2ENSG000001031979


Protein motifs (from Interpro)
Interpro ID Name
 IPR000331  Rap GTPase activating protein domain
 IPR001478  PDZ domain
 IPR021818  Signal-induced proliferation-associated 1-like protein, C-terminal
 IPR031203  Signal-induced proliferation-associated 1-like protein 2
 IPR035974  Rap/Ran-GAP superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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