ENSMUSG00000030583


Mus musculus

Features
Gene ID: ENSMUSG00000030583
  
Biological name :Sipa1l3
  
Synonyms : G3X9J0 / signal-induced proliferation-associated 1 like 3 / Sipa1l3
  
Possible biological names infered from orthology : O60292
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 29320372
Gene end: 29518641
  
Corresponding Affymetrix probe sets: 10561721 (MoGene1.0st)   1428493_at (Mouse Genome 430 2.0 Array)   1457821_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138714
Ensembl peptide - ENSMUSP00000082965
Ensembl peptide - ENSMUSP00000138171
Ensembl peptide - ENSMUSP00000138311
Ensembl peptide - ENSMUSP00000138345
Ensembl peptide - ENSMUSP00000138381
Ensembl peptide - ENSMUSP00000138592
NCBI entrez gene - 74206     See in Manteia.
MGI - MGI:1921456
RefSeq - XM_017312346
RefSeq - NM_001081028
RefSeq - XM_006540405
RefSeq - XM_011250727
RefSeq - XM_011250728
RefSeq - XM_011250729
RefSeq - XM_011250730
RefSeq - XM_011250731
RefSeq - XM_011250732
RefSeq - XM_006540397
RefSeq - XM_006540399
RefSeq - XM_006540400
RefSeq - XM_006540401
RefSeq - XM_006540402
RefSeq - XM_006540403
RefSeq - XM_006540404
RefSeq Peptide - NP_001074497
swissprot - S4R1P8
swissprot - S4R1S0
swissprot - S4R1U8
swissprot - S4R2C7
swissprot - S4R2N4
swissprot - G3X9J0
Ensembl - ENSMUSG00000030583
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sipa1l3ENSDARG00000061699Danio rerio
 O60292ENSG00000105738Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8C0T5 / Sipa1l1 / Signal-induced proliferation-associated 1-like protein 1 / O43166* / signal induced proliferation associated 1 like 1*ENSMUSG0000004270048
Q80TE4 / Sipa1l2 / Mus musculus signal-induced proliferation-associated 1 like 2 (Sipa1l2), transcript variant 2, mRNA. / Q9P2F8* / signal induced proliferation associated 1 like 2*ENSMUSG0000000199545
Sipa1 / signal-induced proliferation-associated 1 / Q96FS4*ENSMUSG0000005691725
Garnl3 / Q3V0G7 / Mus musculus GTPase activating RANGAP domain-like 3 (Garnl3), transcript variant 2, mRNA. / Q5VVW2* / GTPase activating Rap/RanGAP domain like 3*ENSMUSG0000003886014
Q5SVL6 / Rap1gap2 / Rap1 GTPase-activating protein 2 / Q684P5*ENSMUSG0000003880713
Q6GYP7 / Ralgapa1 / Ral GTPase activating protein, alpha subunit 1 / Q6GYQ0* / Ral GTPase activating protein catalytic alpha subunit 1*ENSMUSG0000002102712
A2ALS5 / Rap1gap / Mus musculus Rap1 GTPase-activating protein (Rap1gap), transcript variant 5, mRNA. / P47736* / RAP1 GTPase activating protein*ENSMUSG0000004135111
A3KGS3 / Ralgapa2 / Ral GTPase-activating protein subunit alpha-2 / Q2PPJ7* / Ral GTPase activating protein catalytic alpha subunit 2*ENSMUSG0000003711011
Tsc2 / tuberous sclerosis 2 / P49815* / TSC complex subunit 2*ENSMUSG000000024969


Protein motifs (from Interpro)
Interpro ID Name
 IPR000331  Rap GTPase activating protein domain
 IPR001478  PDZ domain
 IPR021818  Signal-induced proliferation-associated 1-like protein, C-terminal
 IPR031204  Signal-induced proliferation-associated 1-like protein 3
 IPR035974  Rap/Ran-GAP superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IMP
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0003382 epithelial cell morphogenesis IMP
 biological_processGO:0007010 cytoskeleton organization IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction IEA
 biological_processGO:0090162 establishment of epithelial cell polarity IEA
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0061689 tricellular tight junction IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
Show

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0011482 posterior iris synechia "adhesion of the iris to the capsule of the lens or to the surface of the vitreous body" [MGI:anna]
Show

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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