ENSMUSG00000037110


Mus musculus

Features
Gene ID: ENSMUSG00000037110
  
Biological name :Ralgapa2
  
Synonyms : A3KGS3 / Ralgapa2 / Ral GTPase-activating protein subunit alpha-2
  
Possible biological names infered from orthology : Q2PPJ7 / Ral GTPase activating protein catalytic alpha subunit 2
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: G1
Gene start: 146239879
Gene end: 146512344
  
Corresponding Affymetrix probe sets: 10488322 (MoGene1.0st)   1455750_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105613
Ensembl peptide - ENSMUSP00000122017
Ensembl peptide - ENSMUSP00000122039
Ensembl peptide - ENSMUSP00000153734
Ensembl peptide - ENSMUSP00000114547
NCBI entrez gene - 241694     See in Manteia.
MGI - MGI:3036245
RefSeq - XM_006499521
RefSeq - NM_001033348
RefSeq - XM_006499517
RefSeq - XM_006499519
RefSeq Peptide - NP_001028520
swissprot - A0A0A0MQD7
swissprot - F7AI67
swissprot - F7CGP0
swissprot - A3KGS3
Ensembl - ENSMUSG00000037110
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ralgapa2ENSDARG00000005861Danio rerio
 ENSGALG00000044730Gallus gallus
 ENSGALG00000032964Gallus gallus
 Q2PPJ7ENSG00000188559Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6GYP7 / Ralgapa1 / Ral GTPase activating protein, alpha subunit 1 / Q6GYQ0* / Ral GTPase activating protein catalytic alpha subunit 1*ENSMUSG0000002102754
Tsc2 / tuberous sclerosis 2 / P49815* / TSC complex subunit 2*ENSMUSG0000000249616
Q8C0T5 / Sipa1l1 / Signal-induced proliferation-associated 1-like protein 1 / O43166* / signal induced proliferation associated 1 like 1*ENSMUSG0000004270011
G3X9J0 / Sipa1l3 / signal-induced proliferation-associated 1 like 3 / O60292*ENSMUSG0000003058311
Q80TE4 / Sipa1l2 / Mus musculus signal-induced proliferation-associated 1 like 2 (Sipa1l2), transcript variant 2, mRNA. / Q9P2F8* / signal induced proliferation associated 1 like 2*ENSMUSG0000000199510
Sipa1 / signal-induced proliferation-associated 1 / Q96FS4*ENSMUSG000000569178
Garnl3 / Q3V0G7 / Mus musculus GTPase activating RANGAP domain-like 3 (Garnl3), transcript variant 2, mRNA. / Q5VVW2* / GTPase activating Rap/RanGAP domain like 3*ENSMUSG000000388606
A2ALS5 / Rap1gap / Mus musculus Rap1 GTPase-activating protein (Rap1gap), transcript variant 5, mRNA. / P47736* / RAP1 GTPase activating protein*ENSMUSG000000413515
Q5SVL6 / Rap1gap2 / Rap1 GTPase-activating protein 2 / Q684P5*ENSMUSG000000388075


Protein motifs (from Interpro)
Interpro ID Name
 IPR000331  Rap GTPase activating protein domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR027107  Tuberin/Ral GTPase-activating protein subunit alpha
 IPR035974  Rap/Ran-GAP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032484 Ral protein signal transduction IMP
 biological_processGO:0032880 regulation of protein localization IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction IEA
 biological_processGO:0060178 regulation of exocyst localization IMP
 biological_processGO:0090630 activation of GTPase activity IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane ISO
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-CTNNB1)Tcd/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0010289 increased urinary system tumor incidence "greater than the expected number of tumors originating in the urinary system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-CTNNB1)Tcd/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004056 Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*  / reaction






 

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