ENSMUSG00000004056


Mus musculus

Features
Gene ID: ENSMUSG00000004056
  
Biological name :Akt2
  
Synonyms : Akt2 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / Q60823
  
Possible biological names infered from orthology : AKT serine/threonine kinase 2 / P31751
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 27591552
Gene end: 27640826
  
Corresponding Affymetrix probe sets: 10374364 (MoGene1.0st)   10551393 (MoGene1.0st)   1421324_a_at (Mouse Genome 430 2.0 Array)   1424480_s_at (Mouse Genome 430 2.0 Array)   1455703_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117119
Ensembl peptide - ENSMUSP00000103981
Ensembl peptide - ENSMUSP00000117682
Ensembl peptide - ENSMUSP00000132141
Ensembl peptide - ENSMUSP00000123204
Ensembl peptide - ENSMUSP00000122716
Ensembl peptide - ENSMUSP00000120978
Ensembl peptide - ENSMUSP00000052103
Ensembl peptide - ENSMUSP00000083081
Ensembl peptide - ENSMUSP00000103979
Ensembl peptide - ENSMUSP00000103980
NCBI entrez gene - 11652     See in Manteia.
MGI - MGI:104874
RefSeq - XM_011250418
RefSeq - NM_001110208
RefSeq - NM_001331108
RefSeq - NM_001331109
RefSeq - NM_007434
RefSeq - XM_006539477
RefSeq - XM_006539478
RefSeq - XM_006539480
RefSeq - XM_006539481
RefSeq - XM_006539482
RefSeq - XM_006539483
RefSeq Peptide - NP_031460
RefSeq Peptide - NP_001318037
RefSeq Peptide - NP_001318038
RefSeq Peptide - NP_001103678
swissprot - D3Z0M3
swissprot - F8WHG5
swissprot - D3YZJ5
swissprot - Q3TY95
swissprot - Q60823
swissprot - D3YXM7
swissprot - D3Z5X2
swissprot - D3Z490
swissprot - D3Z3N2
Ensembl - ENSMUSG00000004056
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akt2ENSDARG00000011219Danio rerio
 akt2lENSDARG00000103612Danio rerio
 AKT2ENSG00000105221Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*ENSMUSG0000000172982
Akt3 / Q9WUA6 / RAC-gamma serine/threonine-protein kinase / Q9Y243* / AKT serine/threonine kinase 3*ENSMUSG0000001969977
Prkca / protein kinase C, alpha / P17252*ENSMUSG0000005096537
Prkch / P23298 / protein kinase C, eta / P24723*ENSMUSG0000002110837
Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*ENSMUSG0000001997036
Prkcb / P68404 / protein kinase C, beta / P05771*ENSMUSG0000005288936
Prkcq / Q02111 / protein kinase C, theta / Q04759*ENSMUSG0000002677836
Prkcg / P63318 / protein kinase C, gamma / P05129*ENSMUSG0000007881636
Prkce / P16054 / protein kinase C, epsilon / Q02156*ENSMUSG0000004503836
Prkcd / P28867 / protein kinase C, delta / Q05655*ENSMUSG0000002194836
Prkci / Q62074 / protein kinase C, iota / P41743*ENSMUSG0000003764335
Sgk3 / Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Q96BR1* / serum/glucocorticoid regulated kinase family member 3*ENSMUSG0000002591535
Prkcz / Q02956 / protein kinase C, zeta / Q05513*ENSMUSG0000002905334
Sgk2 / Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Q9HBY8* / SGK2, serine/threonine kinase 2*ENSMUSG0000001786833


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR034677  Protein Kinase B beta, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0005978 glycogen biosynthetic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008286 insulin receptor signaling pathway ISO
 biological_processGO:0008643 carbohydrate transport IEA
 biological_processGO:0010748 negative regulation of plasma membrane long-chain fatty acid transport ISO
 biological_processGO:0010765 positive regulation of sodium ion transport ISO
 biological_processGO:0010907 positive regulation of glucose metabolic process ISO
 biological_processGO:0010918 positive regulation of mitochondrial membrane potential ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0031340 positive regulation of vesicle fusion IMP
 biological_processGO:0032000 positive regulation of fatty acid beta-oxidation ISO
 biological_processGO:0032287 peripheral nervous system myelin maintenance IMP
 biological_processGO:0032869 cellular response to insulin stimulus ISO
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process ISO
 biological_processGO:0046326 positive regulation of glucose import ISO
 biological_processGO:0065002 intracellular protein transmembrane transport IMP
 biological_processGO:0071486 cellular response to high light intensity IMP
 biological_processGO:0072659 protein localization to plasma membrane IGI
 biological_processGO:0090314 positive regulation of protein targeting to membrane IMP
 biological_processGO:0090630 activation of GTPase activity IGI
 biological_processGO:0097473 retinal rod cell apoptotic process IMP
 biological_processGO:2000147 positive regulation of cell motility ISO
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005938 cell cortex IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032587 ruffle membrane IMP
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity EXP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
Activation of AKT2
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
AKT-mediated inactivation of FOXO1A
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
CTLA4 inhibitory signaling
G beta:gamma signalling through PI3Kgamma
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
RAB GEFs exchange GTP for GDP on RABs
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0000734 muscle hypoplasia "underdevelopment or atrophy of muscle" [J:15108]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Rdh10trex/Rdh10trex
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Akt2tm1Hem/Akt2tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001201 translucent skin "skin that is more transparent to light than normal " [J:15108]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001238 thin epidermal spinous layer "reduced thickness of the stratum spinosum; the polyhedral cell layer" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:15108]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt1tm1Hem/Akt1+,Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt2tm1.2Mbb/Akt2tm1.2Mbb,Lepob/Lepob,Tg(Alb1-cre)1Khk/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

Allelic Composition: Akt2tm1.1Mbb/Akt2+,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Akt2tm1Hem/Akt2tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt1tm1Hem/Akt1+,Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt2tm1Hem/Akt2tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg,Akt3tm1Nhy/Akt3tm1Nhy
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akt2tm1Rsg/Akt2tm1Rsg,Ptentm1Ppp/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/1LacJ

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Akt3tm1Mbb/Akt3tm1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Akt3tm1Mbb/Akt3tm1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/He * C57BL/6

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Rdh10trex/Rdh10trex
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt2tm1Hem/Akt2tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg,Ptentm1Ppp/Pten+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: C57BL/6 * DBA/1LacJ

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: B6.129P2-Akt2tm1.1Mbb

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Akt2tm1.2Mbb/Akt2tm1.2Mbb,Lepob/Lepob,Tg(Alb1-cre)1Khk/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002680 decreased number of corpora lutea "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rdh10trex/Rdh10trex
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Akt2tm1Rsg/Akt2tm1Rsg,Ptentm1Ppp/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/1LacJ

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002781 increased circulating testosterone level "greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rdh10trex/Rdh10trex
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akt2tm1.2Mbb/Akt2tm1.2Mbb,Lepob/Lepob,Tg(Alb1-cre)1Khk/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

Allelic Composition: Akt2tm1.1Mbb/Akt2+,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Akt3tm1Mbb/Akt3tm1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Akt3tm1Mbb/Akt3tm1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt2tm1Hem/Akt2tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg,Ptentm1Ppp/Pten+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt2tm1Rsg/Akt2tm1Rsg,Ptentm1Ppp/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: C57BL/6 * DBA/1LacJ

Allelic Composition: Akt2tm1Rsg/Akt2tm1Rsg,Akt3tm1Nhy/Akt3tm1Nhy
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt2tm1Hem/Akt2tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: C57BL/6 * DBA/1LacJ

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Akt2tm1.2Mbb/Akt2tm1.2Mbb,Lepob/Lepob,Tg(Alb1-cre)1Khk/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: B6.129P2-Akt2tm1.1Mbb

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: B6.129P2-Akt2tm1.1Mbb

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: C57BL/6 * DBA/1LacJ

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Akt3tm1Mbb/Akt3tm1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0009167 increased pancreatic islet number "increase in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg,Ptentm1Ppp/Pten+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: C57BL/6 * DBA/1LacJ

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Akt2tm1.2Mbb/Akt2tm1.2Mbb,Tg(Alb1-cre)1Khk/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Akt2tm1.2Mbb/Akt2tm1.2Mbb,Lepob/Lepob,Tg(Alb1-cre)1Khk/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: B6.129P2-Akt2tm1.1Mbb

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

Allelic Composition: Akt2tm1.1Mbb/Akt2+,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

 MP:0009371 increased thecal cell number "greater than normal numbers of cells in the sheath of stroma surrounding a secondary ovarian follicle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rdh10trex/Rdh10trex
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0014146 decreased white adipose tissue mass "decreasd physical bulk or volume of white adipose tissue" [MGI:csmith]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0014169 decreased brown adipose tissue mass "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032715 Trib3 / Q8K4K2 / Tribbles homolog 3 / Q96RU7* / tribbles pseudokinase 3*  / complex
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / reaction
 ENSMUSG00000028145 Them4 / Q3UUI3 / Acyl-coenzyme A thioesterase THEM4 / Q5T1C6* / thioesterase superfamily member 4*  / complex
 ENSMUSG00000002496 Tsc2 / tuberous sclerosis 2 / P49815* / TSC complex subunit 2*  / reaction
 ENSMUSG00000026812 Tsc1 / Q9EP53 / Hamartin / Q92574* / TSC complex subunit 1*  / reaction
 ENSMUSG00000030279 C2cd5 / Q7TPS5 / C2 domain-containing protein 5 / Q86YS7* / C2 calcium dependent domain containing 5*  / reaction
 ENSMUSG00000022428 1 / Cby1 / Q9D1C2 / Q9Y3M2* / chibby family member 1, beta catenin antagonist*  / reaction
 ENSMUSG00000034593 Myo5a / Q99104 / Unconventional myosin-Va / Q9Y4I1* / myosin VA*  / reaction
 ENSMUSG00000037110 A3KGS3 / Ralgapa2 / Ral GTPase-activating protein subunit alpha-2 / Q2PPJ7* / Ral GTPase activating protein catalytic alpha subunit 2*  / reaction
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction






 

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